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1
US2021052874A1
ULTRASOUND DEVICE AND THERAPEUTIC METHODS
Publication/Patent Number: US2021052874A1 Publication Date: 2021-02-25 Application Number: 17/072,435 Filing Date: 2020-10-16 Inventor: Lewin, Peter A.   Papazoglou, Elizabeth S. S.   Sunny, Youhan   Bawiec, Chris R.   Zubkov, Leonid   Nguyen, An   Samuels, Joshua   Assignee: DREXEL UNIVERSITY   IPC: A61M37/00 Abstract: The present invention is directed to an ultrasound device for use in implementing therapeutic treatments and transdermal analyte delivery. The device includes a piezoelectric transducer that efficiently and safely converts electrical energy to ultrasonic waves, and has a unique structure including a piezoelectric element positioned between two opposing, flexible concave covers. The device may be used for various therapeutic purposes including wound healing, tissue stimulation and transdermal analyte delivery. The invention is further directed to a novel analyte delivery system including the ultrasound device and an encapsulated analyte.
2
US2021047758A1
Method to Produce Micro and Nanofibers with Controlled Diameter and Large Yield
Publication/Patent Number: US2021047758A1 Publication Date: 2021-02-18 Application Number: 17/085,508 Filing Date: 2020-10-30 Inventor: Han, Li-hsin   Wang, Mingkun   Cui, Chunxiao   Clyne, Alisa Morss   Alhindi, Momtaz   Krystek, Jeffrey   Micucci, Victor   Ostrow, Evan   Shafi, Sabah   Han, Lin   He, Lanziye   Assignee: DREXEL UNIVERSITY   IPC: D02J1/22 Abstract: In one embodiment, the present invention is a method for producing microfibers comprising the steps of: (a) providing a base material; (b) forming the base material in a ring; (c) gripping opposing ends of the ring; (d) flipping one of the opposing ends relative to the other of the opposing ends, forming an upper portion and a lower portion; (e) folding the upper portion onto the lower portion; (f) stretching the folded upper and lower portions; and (g) repeating steps (d)-(f) as desired.
3
US2021196841A1
Methods of Imaging and Delivering Therapeutic Agents
Publication/Patent Number: US2021196841A1 Publication Date: 2021-07-01 Application Number: 17/204,561 Filing Date: 2021-03-17 Inventor: Wrenn, Steven   Angel, Brett   Kohut, Andrew   Fafarman, Aaron   Cimorelli, Michael   Assignee: DREXEL UNIVERSITY   IPC: A61K49/22 Abstract: The present disclosure provides imaging agents that are useful for the detection and evaluation of heart conditions, such as myocardial infarction. Upon activation, the imaging agents of the present disclosure may be detected using an ultrasound imaging device.
4
US2021260395A1
USE OF COLD ATMOSPHERIC PRESSURE PLASMA TO TREAT WARTS
Publication/Patent Number: US2021260395A1 Publication Date: 2021-08-26 Application Number: 17/255,853 Filing Date: 2019-06-26 Inventor: Friedman, Peter C.   Miller, Vandana   Fridman, Gregory   Lin, Abraham   Fridman, Alexander   Assignee: DREXEL UNIVERSITY   IPC: A61N1/44 Abstract: A method for treating a wart on skin of a patient includes guiding non-thermal, atmospheric pressure plasma over areas of the tissue having the wart for a length of time effective to give rise to an at least partial amelioration of the wart.
5
US2021104342A1
Soft Magnetic Composites for Electric Motors
Publication/Patent Number: US2021104342A1 Publication Date: 2021-04-08 Application Number: 17/118,001 Filing Date: 2020-12-10 Inventor: Taheri, Mitra Lenore   Sunday, Katie Jo   Spurgeon, Steven Richard   May, Steven Joseph   Assignee: DREXEL UNIVERSITY   IPC: H01F1/33 Abstract: A soft magnetic composite comprising an iron or iron alloy ferromagnetic material coated with an oxide material. An interface between the ferromagnetic material and the layer of oxide contains antiphase domain boundaries. Two processes for producing a soft magnetic composite are also provided. One process includes depositing an oxide layer onto an iron or iron alloy ferromagnetic material by molecular beam epitaxy at a partial oxygen pressure of from 1×10−5 Torr to 1×10−7 Torr to form a coated composite. The other process includes milling an iron or iron alloy ferromagnetic material powder and an oxide powder by high-energy milling to form a mixture; compacting the mixture and curing in an inert gas atmosphere at a temperature from 500° C. to 1200° C. to form a soft magnetic composite.
6
US2021033606A1
DNA mapping and sequencing on linearized DNA molecules
Publication/Patent Number: US2021033606A1 Publication Date: 2021-02-04 Application Number: 16/945,638 Filing Date: 2020-07-31 Inventor: Xiao, Ming   Varapula, Dharma Teja   Labouff, Eric Michael   Noh, Moses   Assignee: DREXEL UNIVERSITY   IPC: G01N33/552 Abstract: The present invention provides novel methods for immobilizing and/or optically mapping oligonucleotides, the method comprising immobilizing the oligonucleotides on a micropatterned substrate. In another aspect, the invention provides a method for mapping a genome, wherein the method is capable of resolving a single nucleotide polymorphism (SNP), the method comprising introducing to the genome a CRISPR/Cas9 system comprising at least one single-guide RNA (sgRNA) specific for a target sequence or a plurality of target sequences across the genome and a Cas9 D10A, wherein the CRISPR/Cas9 system nick labels the target sequence, and the target sequence or genome is analyzed.
7
US2021106968A1
METHOD FOR GENERATION OF NOVEL MATERIALS USING NANOSECOND-PULSED DISCHARGE PLASMA IN LIQUID PHASE
Publication/Patent Number: US2021106968A1 Publication Date: 2021-04-15 Application Number: 16/922,709 Filing Date: 2020-07-07 Inventor: Dobrynin, Danil V.   Fridman, Alexander   Assignee: DREXEL UNIVERSITY   IPC: B01J19/08 Abstract: A method for generation of material in a liquid phase comprising a step of subjecting the liquid phase to a nanosecond-pulsed discharge plasma.
8
US2021210766A1
RAPID SULFUR MELT DIFFUSION INTO CARBON HOST FOR MAKING ELECTRODES
Publication/Patent Number: US2021210766A1 Publication Date: 2021-07-08 Application Number: 17/187,217 Filing Date: 2021-02-26 Inventor: Dillard, Caitlin Nicole   Kalra, Vibha   Assignee: DREXEL UNIVERSITY   IPC: H01M4/88 Abstract: A free-standing electrically conductive porous structure suitable to be used as a cathode of a battery, including an electrically conductive porous substrate with sulfur diffused into the electrically conductive porous substrate to create a substantially uniform layer of sulfur on a surface of the electrically conductive porous substrate. The free-standing electrically conductive porous structure has a high performance when used in a rechargeable battery. A method of manufacturing the electrically conductive porous structure is also provided.
9
US2021054003A1
Methods for the preparation of cyclopentaoxasilinones and cyclopentaoxaborininones and their use
Publication/Patent Number: US2021054003A1 Publication Date: 2021-02-25 Application Number: 16/997,603 Filing Date: 2020-08-19 Inventor: Martinez, Dionicio Solorio   Gallagher, Austin Gregory   Tian, Huan   Assignee: DREXEL UNIVERSITY   IPC: C07F7/20 Abstract: In various aspects and embodiments the invention provides a method of preparing a cyclopentaoxasilinone, the method comprising contacting a siloxy-tethered 1,7-enyne with a thioether promoter. In another aspect, the invention provides a method of preparing a cyclopentaoxaborininone, the method comprising contacting a boronic ester-tethered 1,7-enyne with a thioether promoter.
10
US2021115061A1
Small-Molecule HIV-1 Capsid Protein Inhibitors and Methods Using Same
Publication/Patent Number: US2021115061A1 Publication Date: 2021-04-22 Application Number: 17/254,476 Filing Date: 2019-06-21 Inventor: Cocklin, Simon   Assignee: DREXEL UNIVERSITY   IPC: C07D495/04 Abstract: The present invention provides a method of treating, ameliorating, and/or preventing HIV-I infection in a subject, comprising the step of administering to the subject one or more of the compounds useful within the invention.
11
US2021023089A1
Compositions Useful for Treating Herpes Simplex Keratitis, and Methods Using Same
Publication/Patent Number: US2021023089A1 Publication Date: 2021-01-28 Application Number: 17/064,101 Filing Date: 2020-10-06 Inventor: Clifford, Jane E.   Alekseev, Oleg   Jennings, Stephen R.   Assignee: DREXEL UNIVERSITY   IPC: A61K31/5377 Abstract: The present invention relates generally to compositions and methods for treating diseases and disorders caused by herpes simplex virus type 1, including herpes simplex keratitis, in a subject. In certain embodiments, the compositions of the present invention comprise an ATM inhibitor and an anti-herpetic agent. In other embodiments, the compositions comprise a Chk2 inhibitor and an anti-herpetic agent. In yet other embodiments, the compositions comprise a Chk2 inhibitor and an ATM inhibitor, and optionally an anti-herpetic agent.
12
US2021040108A1
Inhibitors of RAD52 Recombination Protein and Methods Using Same
Publication/Patent Number: US2021040108A1 Publication Date: 2021-02-11 Application Number: 16/933,546 Filing Date: 2020-07-20 Inventor: Mazin, Alexander V.   Assignee: DREXEL UNIVERSITY   IPC: C07D495/04 Abstract: The present invention includes novel RAD52 inhibitors for preventing or treating cancers in a subject in need thereof. The present invention further includes a method of preventing or treating cancers in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In certain embodiments, the subject is further administered at least one additional therapeutic agent.
13
US2021033627A1
Diagnosis of Liver Pathology Through Assessment of Protein Glycosylation
Publication/Patent Number: US2021033627A1 Publication Date: 2021-02-04 Application Number: 17/060,795 Filing Date: 2020-10-01 Inventor: Block, Timothy M   Comunale, Mary Ann   Mehta, Anand   Assignee: DREXEL UNIVERSITY   IPC: G01N33/68 Abstract: Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting lectin binding on proteins in biological fluids, and comparing the detected lectin binding with reference values for the binding of lectin of such proteins in healthy or disease states.
14
US2021282831A1
DEVICES AND METHODS FOR TREATMENT OF SKIN CONDITIONS
Publication/Patent Number: US2021282831A1 Publication Date: 2021-09-16 Application Number: 16/321,686 Filing Date: 2017-08-01 Inventor: Friedman, Peter C.   Miller, Vandana   Fridman, Gregory   Lin, Abraham   Fridman, Alexander   Assignee: DREXEL UNIVERSITY   IPC: A61B18/04 Abstract: Disclosed is a method for treating actinic keratosis of tissue of a patient, the method including contacting non-thermal, atmospheric pressure plasma over areas of the tissue having actinic keratosis for a time and at treatment conditions effective to give rise to an at least partial amelioration of the keratosis.
15
US2021113455A1
Encapsulation of Microbubbles Within the Aqueous Core of Microcapsules
Publication/Patent Number: US2021113455A1 Publication Date: 2021-04-22 Application Number: 16/887,974 Filing Date: 2020-05-29 Inventor: Wrenn, Steven P.   Dicker, Stephen   Assignee: DREXEL UNIVERSITY   IPC: A61K9/00 Abstract: The present invention includes a construct that comprises at least one microbubble encapsulated within the aqueous core of a microcapsule. The present invention also includes a pharmaceutical composition comprising a construct comprising at least one microbubble encapsulated within the aqueous core of a microcapsule. The present invention further includes a method of imaging a tissue or organ in a subject, a method of delivering a therapeutic cargo to a tissue or organ in a subject, and a method of treating a disease or disorder in a subject.
16
US10971733B2
Rapid sulfur melt diffusion into carbon host for making electrodes
Publication/Patent Number: US10971733B2 Publication Date: 2021-04-06 Application Number: 15/881,172 Filing Date: 2018-01-26 Inventor: Dillard, Caitlin Nicole   Kalra, Vibha   Assignee: Drexel University   IPC: H01M4/88 Abstract: A free-standing electrically conductive porous structure suitable to be used as a cathode of a battery, including an electrically conductive porous substrate with sulfur diffused into the electrically conductive porous substrate to create a substantially uniform layer of sulfur on a surface of the electrically conductive porous substrate. The free-standing electrically conductive porous structure has a high performance when used in a rechargeable battery. A method of manufacturing the electrically conductive porous structure is also provided.
17
US2021111390A1
FREE-STANDING, BINDER-FREE METAL MONOXIDE/SUBOXIDE NANOFIBER AS CATHODES OR ANODES FOR BATTERIES
Publication/Patent Number: US2021111390A1 Publication Date: 2021-04-15 Application Number: 17/112,445 Filing Date: 2020-12-04 Inventor: Singh, Arvinder   Kalra, Vibha   Assignee: Drexel University   IPC: H01M4/131 Abstract: A nanofiber mat comprises metal oxide nanoparticles distributed on surface of metal oxide nanofibers, wherein the nanofiber mat has a surface area at least 150 m2/g, and the metal oxide is selected from titanium monoxide TiOx, wherein 0.65<x<1.25, niobium monoxide NbOx, wherein 0.982<x<1.008, vanadium (II) oxide VOx, wherein 0.79 <x <1.29, iron (II) oxide FexO, wherein 0.833<x<0.957, manganese (II) oxide MnxO, wherein 0.848<x<1.000, titanium suboxide, TiOnO2n-1, wherein n>1, molybdenum suboxide, MonO3n-1, wherein n>1, MonO3n-2, wherein n>1, and vanadium suboxide, VnO2n-1, wherein n>1. Cathodes, anodes and batteries are made using the nanofiber mat. Processes for producing the metal oxide nanofiber mat and an electrode including it are also provided.
18
US2021139987A1
METHODS, COMPUTER-READABLE MEDIA, AND SYSTEMS FOR ASSESSING SAMPLES AND WOUNDS, PREDICTING WHETHER A WOUND WILL HEAL, AND MONITORING EFFECTIVENESS OF A TREATMENT
Publication/Patent Number: US2021139987A1 Publication Date: 2021-05-13 Application Number: 17/140,047 Filing Date: 2021-01-02 Inventor: Spiller, Kara   Nassiri, Sina   Weingarten, Michael   Assignee: Drexel University   IPC: C12Q1/6881 Abstract: One aspect of the invention provides a method of predicting whether a wound will heal. The method includes: obtaining a first measurement of a first macrophage phenotype population within a first sample obtained from a wound; obtaining a second measurement of a second macrophage phenotype population from the wound, wherein the second measurement of the second macrophage phenotype population is either: a different macrophage phenotype obtained from the first sample or the same macrophage phenotype obtained from a second, later sample from the wound; comparing the first measurement to the second measurement; and predicting whether the wound will heal based on a result of the comparing step.