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1
US2021047701A1
SACCHAROMYCES CEREVISIAE TCI907, COMPOSITION AND USE OF SACCHAROMYCES CEREVISIAE TCI907, AND/OR ITS METABOLITES
Publication/Patent Number: US2021047701A1 Publication Date: 2021-02-18 Application Number: 16/993,280 Filing Date: 2020-08-14 Inventor: Huang, Chu-han   Lin, Yung-hsiang   Assignee: Tci co ltd   IPC: C12R1/865 Abstract: Saccharomyces cerevisiae TCI907 was deposited in the German Collection of Microorganisms and Cell Cultures under the accession number DSMZ33480. The Saccharomyces cerevisiae TCI907 and/or its metabolites can be used to prepare compositions that regulate blood glucose, lose weight or reduce the production of advanced glycation end products.
2
US10918682B2
Method of enhancing the gene expression level of TGM1, KRT, AQP3, FLG, GBA, and HAS using plant extracts
Publication/Patent Number: US10918682B2 Publication Date: 2021-02-16 Application Number: 16/499,436 Filing Date: 2018-04-03 Inventor: Lin, Yung-hsiang   Chen, I-hui   Kan, Kai-wen   Liu, Fu Chen   Chen, Ciao-ting   Assignee: Tci co ltd   IPC: A61K36/00 Abstract: The present invention provides a method of a composition containing plant extracts for enhancing the gene expression level of TGM1, KRT, AQP3, FLG, GBA, and HAS. Compared to a single plant extract, the combination of the plant extracts of the present invention can more effectively enhance the expression level of skin moisturizing genes. The plant extracts constituting the composition include: an extract of spinach, blueberry, Pu-erh tea, or Four Seasons Spring tea.
3
US10933107B2
Composition comprising plant extract and use thereof
Publication/Patent Number: US10933107B2 Publication Date: 2021-03-02 Application Number: 16/499,473 Filing Date: 2018-04-03 Inventor: Lin, Yung-hsiang   Chen, I-hui   Kan, Kai-wen   Liu, Fu Chen   Chen, Ciao-ting   Assignee: Tci co ltd   IPC: A61K36/00 Abstract: Provided is a composition comprising a plant extract. The plant extract includes a citrus extract and a green tea extract. The extract combination can effectively increase expression of GLUT4 gene.
4
US2021000893A1
LACTOBACILLUS PLANTARUM STRAIN TCI227 AND USES OF THE LACTOBACILLUS PLANTARUM STRAIN TCI227 FOR REGULATING EXPRESSION OF IL-1BETA GENE, TNF-ALPHA GENE, MMP1a GENE AND TIMP1 GENE, AND TREATING GOUT
Publication/Patent Number: US2021000893A1 Publication Date: 2021-01-07 Application Number: 16/693,758 Filing Date: 2019-11-25 Inventor: Lin, Yung-hsiang   Huang, Chu-han   Ho, Cheng-yu   Assignee: Tci co ltd   IPC: A61K35/747 Abstract: The present disclosure provides a Lactobacillus plantarum strain and a method for regulating expression of IL-1β gene, TNF-α gene, MMP1α gene and TIMP1 gene, and treating gout using the Lactobacillus plantarum strain.
5
US10940174B1
Methods for skin whitening, ultraviolet radiation protection and suppression of glycation using green mango extracts and compounds obtained therefrom
Publication/Patent Number: US10940174B1 Publication Date: 2021-03-09 Application Number: 16/561,083 Filing Date: 2019-09-05 Inventor: Lin, Yung-hsiang   Yu, Chin-hsiu   Chung, Yu-ming   Assignee: Tci co ltd   IPC: A61K36/00 Abstract: Provided is a method for skin whitening, ultraviolet radiation protection, and anti-glycation by using a green mango extract. Also provided is a method for anti-glycation by using compounds of hydrolyzable tannins isolated from the green mango extract.
6
US2021069272A1
METHODS FOR SKIN WHITENING, ULTRAVIOLET RADIATION PROTECTION AND SUPPRESSION OF GLYCATION USING GREEN MANGO EXTRACTS AND COMPOUNDS OBTAINED THEREFROM
Publication/Patent Number: US2021069272A1 Publication Date: 2021-03-11 Application Number: 16/561,083 Filing Date: 2019-09-05 Inventor: Lin, Yung-hsiang   Yu, Chin-hsiu   Chung, Yu-ming   Assignee: Tci co ltd   IPC: A61K36/22 Abstract: Provided is a method for skin whitening, ultraviolet radiation protection, and anti-glycation by using a green mango extract. Also provided is a method for anti-glycation by using compounds of hydrolyzable tannins isolated from the green mango extract.
7
US2021069223A1
USE OF COMPOUND FOR PREVENTING AND/OR TREATING OBESITY
Publication/Patent Number: US2021069223A1 Publication Date: 2021-03-11 Application Number: 17/016,384 Filing Date: 2020-09-10 Inventor: Lin, Yung-hsiang   Assignee: Tci co ltd   IPC: A61K31/7048 Abstract: A method of preventing and/or treating obesity is provided. The method includes administering a composition to a subject, and the composition has at least one compound selected from the group consisting of 4-hydroxy-3-methoxycinnamic acid (also referred to as (E)-3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoic acid), 7-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, and 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one. The compound can effectively promote lipolysis and/or reduce the cell fat content and can effectively reduce the fat content in cells to achieve the purpose of preventing and/or treating obesity.
8
US2021046126A1
USE OF BACILLUS COAGULANS IN PREPARING COMPOSITIONS FOR SOBERING UP AND FOOD PRODUCT FOR SOBERING UP
Publication/Patent Number: US2021046126A1 Publication Date: 2021-02-18 Application Number: 16/993,284 Filing Date: 2020-08-14 Inventor: Chiu, Yu-kai   Lin, Yung-hsiang   Assignee: Tci co ltd   IPC: A61K35/742 Abstract: A use of Bacillus coagulans TCI711 in preparing compositions for sobering up is provided. The Bacillus coagulans TCI711 is deposited in Consortium Food Industry Research and Development Institute (Deposit number: BCRC910807) and German Microbial and Cell Culture Collection Center (DSMZ-DEUTSCHE SAMMLUNG VON MIKROORGANISMEN UND ZELLKULTUREN GmbH) (Deposit number: DSM33163).
9
US2021009637A1
BIOMIMETIC PEPTIDES DERIVED FROM BIOLOGICAL SOURCE AND THEIR USES IN RETARDING AGING AND IMPROVING SKIN
Publication/Patent Number: US2021009637A1 Publication Date: 2021-01-14 Application Number: 16/702,385 Filing Date: 2019-12-03 Inventor: Lin, Yung-hsiang   Wang, Yu-ling   Assignee: Tci co ltd   IPC: C07K7/06 Abstract: The present disclosure provides peptides comprising a motif having four amino acids, wherein each of the amino acids at N-terminus and C-terminus of the sequence independently has a same or different positively charged side chain, and each of the amino acids between the N-terminal and C-terminal of the motif independently has a same or different uncharged side chain. The present disclosure surprisingly found that these peptides have advantageous effects in inhibiting or decreasing collagen breakdown, increasing production of collagen, elastin and/or hyaluronic acid, retarding aging, improving skin and inhibiting inflammation.
10
US2021007986A1
LIPOSOME COMPOSITION WITH ADIPOCYTE SPECIFICITY AND PREPARATION PROCESS THEREOF
Publication/Patent Number: US2021007986A1 Publication Date: 2021-01-14 Application Number: 16/921,964 Filing Date: 2020-07-07 Inventor: Lin, Yung-hsiang   Chang, Jung   Assignee: Tci co ltd   IPC: A61K9/127 Abstract: A liposome composition with adipocyte specificity comprises a shell formed by a liposome material, and a ligand material bound to a surface of the shell. The ligand material is a plurality of long chain fatty acids, and the liposome composition recognizes and binds to an adipocyte by the plurality of long chain fatty acids.
11
US10918683B2
Methods to reduce fat accumulation and oxidative damage in liver using green mango extracts and compounds obtained therefrom
Publication/Patent Number: US10918683B2 Publication Date: 2021-02-16 Application Number: 16/502,102 Filing Date: 2019-07-03 Inventor: Lin, Yung-hsiang   Yu, Chin-hsiu   Lin, Shan-yu   Assignee: Tci co ltd   IPC: A61K36/00 Abstract: Provided is a method for reducing fat accumulation in and oxidative damage to liver cells by using a green mango extract. Also provided is a method for reducing fat accumulation in liver cells by using compounds of hydrolyzable tannins isolated from the green mango extract.
12
US2021015736A1
HALOBACILLUS TRUEPERI TCI66207 AND BACTERIAL LYSATE THEREOF AND USE OF BACTERIAL LYSATE
Publication/Patent Number: US2021015736A1 Publication Date: 2021-01-21 Application Number: 16/932,867 Filing Date: 2020-07-20 Inventor: Huang, Chu-han   Lin, Yung-hsiang   Assignee: Tci co ltd   IPC: A61K8/99 Abstract: A Halobacillus trueperi TCI66207 strain, deposited in Non-profit Private Entity Food Industry Research and Development Institute (Deposit number: BCRC910961). The H. trueperi TCI66207 strain has one or more of the following function: improving skin cell mitochondrion activity, promoting skin cell proliferation, maintaining skin corneum layer completeness, increasing expression of cornifin (Keratin14) and/or hyaluronic acid synthase (HAS3) genes and promoting hyaluronic acid production.
13
US2021023159A1
METHOD FOR PROMOTING GROWTH OF AKKERMANSIA MUCINIPHILA USING MUSA FERMENTS
Publication/Patent Number: US2021023159A1 Publication Date: 2021-01-28 Application Number: 16/727,389 Filing Date: 2019-12-26 Inventor: Lin, Yung-hsiang   Huang, Chu-han   Ho, Cheng-yu   Assignee: Tci co ltd   IPC: A61K36/88 Abstract: Provided is a method of promoting the growth of Akkermansia muciniphila, including contacting A. muciniphila with an effective amount of a prebiotic composition including a Musa ferment. Also provided is a prebiotic composition including a Musa ferment. The prebiotic composition promotes the growth of A. muciniphila in the intestine, and reduces the body weight, fat percentage, waist circumference, and hip circumference of obese individuals.
14
US10905674B2
Method of increasing melatonin synthesis to treat insomnia, ameliorate sleep disturbance and regulate sleep
Publication/Patent Number: US10905674B2 Publication Date: 2021-02-02 Application Number: 16/776,190 Filing Date: 2020-01-29 Inventor: Lin, Yung-hsiang   Yu, Chin-hsiu   Su, Yu-hung   Lin, Shan-yu   Chung, Yu-ming   Assignee: Tci co ltd   IPC: A61K31/122 Abstract: A method for at least one of increasing the synthesis of melatonin and promoting the secretion of melatonin is provided, wherein the method comprises administering to a subject in need an effective amount of a compound of formula (I): A method for at least one of treating diseases related to neurometabolic disorder, preventing diseases related to neurometabolic disorder, regulating appetite, regulating mood, regulating vasoconstriction, regulating hemostatic function and regulating immune response is also provided, wherein the method comprises administering to a subject in need an effective amount of a compound of formula (I) as described above.
15
US10918681B2
Method for regulating expression of PDGFC, FGF2, IGF1R, PTGIS, NOS3, EDN1, PLAT, PROC, VWF, F3, SERPINE1, IL-8, ICAM1, VCAM1, and CASP8 genes
Publication/Patent Number: US10918681B2 Publication Date: 2021-02-16 Application Number: 16/498,737 Filing Date: 2018-04-03 Inventor: Lin, Yung-hsiang   Chen, I-hui   Kan, Kai-wen   Liu, Fu Chen   Chen, Ciao-ting   Assignee: Tci co ltd   IPC: A61K36/00 Abstract: The present disclosure provides a method for regulating expression of PDGFC, FGF2, IGF1R, PTGIS, NOS3, EDN1, PLAT, PROC, VWF, F3, SERPINE1, IL-8, ICAM1, VCAM1, and CASP8 genes, including administering to a subject in need thereof a composition including an effective amount of a plant extract, wherein the plant extract includes at least one combination selected from the group consisting of a grape seed extract and a Four seasons spring tea extract, a black tea extract and a spinach extract, the grape seed extract and the spinach extract, the grape seed extract and a green coffee bean extract, a red wine extract and a Pu-erh tea extract, and the grape seed extract and the Pu-erh tea extract.
16
EP3763225A1
BLACK RICE EXTRACT FERMENTS AND THE PREPARATION METHODS AND APPLICATIONS THEREOF
Publication/Patent Number: EP3763225A1 Publication Date: 2021-01-13 Application Number: 20182011.5 Filing Date: 2020-06-24 Inventor: Huang, Chu-han   Chung, Yu-ming   Lin, Yung-hsing   Assignee: Tci co ltd   IPC: A23L33/10 Abstract: A composition comprising a fermentation product of black rice extract, uses of the fermentation product and its active ingredients, and a method for manufacturing the fermentation product. The fermentation product of black rice extract comprises at least one of the following compounds of formula (I) to formula (V):
17
EP3763725A1
BIOMIMETIC PEPTIDES DERIVED FROM BIOLOGICAL SOURCE AND THEIR USES IN RETARDING AGING AND IMPROVING SKIN
Publication/Patent Number: EP3763725A1 Publication Date: 2021-01-13 Application Number: 19203345.4 Filing Date: 2019-10-15 Inventor: Lin, Yung-hsiang   Wang, Yu-ling   Assignee: Tci co ltd   IPC: C07K7/06 Abstract: The present disclosure provides peptides comprising a motif having four amino acids, wherein each of the amino acids at N-terminus and C-terminus of the sequence independently has a same or different positively charged side chain, and each of the amino acids between the N-terminal and C-terminal of the motif independently has a same or different uncharged side chain. The present disclosure surprisingly found that these peptides have advantageous effects in inhibiting or decreasing collagen breakdown, increasing production of collagen, elastin and/or hyaluronic acid, retarding aging, improving skin and inhibiting inflammation.
18
EP3763392A1
LIPOSOME COMPOSITION WITH ADIPOCYTE SPECIFICITY AND PREPARATION PROCESS THEREOF
Publication/Patent Number: EP3763392A1 Publication Date: 2021-01-13 Application Number: 20184431.3 Filing Date: 2020-07-07 Inventor: Lin, Yung-hsiang   Chang, Jung   Assignee: Tci co ltd   IPC: A61K47/69 Abstract: A liposome composition with adipocyte specificity comprises a shell formed by a liposome material, and a ligand material bound to a surface of the shell. The ligand material is a plurality of long chain fatty acids (11), and the liposome composition recognizes and binds to an adipocyte (21) by the plurality of long chain fatty acids (11).
19
US10898429B2
Uses of coffee pulp extract
Publication/Patent Number: US10898429B2 Publication Date: 2021-01-26 Application Number: 16/241,722 Filing Date: 2019-01-07 Inventor: Lin, Yung-hsiang   Li, Zih-yi   Assignee: Tci co ltd   IPC: A61K36/74 Abstract: A method for at least one of whitening skin, improving skin condition, protecting skin and inhibiting skin aging is provided, wherein the method comprises administering to a subject in need an effective amount of a coffee pulp extract. A method for at least one of repairing skin tissues, preventing skin disease, and treating skin disease is also provided, wherein the method comprises administering to a subject in need an effective amount of a coffee pulp extract.
20
US10555984B2
Method for increasing expression of PDPRD gene by using peanut skin extract
Publication/Patent Number: US10555984B2 Publication Date: 2020-02-11 Application Number: 15/957,630 Filing Date: 2018-04-19 Inventor: Lin, Yung-hsiang   Yu, Chih-hsiu   Assignee: Tci co ltd   IPC: A61K36/48 Abstract: A method for increasing the expression of PTPRD gene is provided, wherein the method comprises administering to a subject in need an effective amount of a peanut skin extract. The method is effective in preventing or treating diseases related to PTPRD gene.
Total 23 pages