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1 | US2021047701A1 |
SACCHAROMYCES CEREVISIAE TCI907, COMPOSITION AND USE OF SACCHAROMYCES CEREVISIAE TCI907, AND/OR ITS METABOLITES
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Publication/Patent Number: US2021047701A1 | Publication Date: 2021-02-18 | Application Number: 16/993,280 | Filing Date: 2020-08-14 | Inventor： Huang, Chu-han Lin, Yung-hsiang | Assignee: Tci co ltd | IPC: C12R1/865 | Abstract: Saccharomyces cerevisiae TCI907 was deposited in the German Collection of Microorganisms and Cell Cultures under the accession number DSMZ33480. The Saccharomyces cerevisiae TCI907 and/or its metabolites can be used to prepare compositions that regulate blood glucose, lose weight or reduce the production of advanced glycation end products. | |||
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2 | US10918682B2 |
Method of enhancing the gene expression level of TGM1, KRT, AQP3, FLG, GBA, and HAS using plant extracts
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Publication/Patent Number: US10918682B2 | Publication Date: 2021-02-16 | Application Number: 16/499,436 | Filing Date: 2018-04-03 | Inventor： Lin, Yung-hsiang Chen, I-hui Kan, Kai-wen Liu, Fu Chen Chen, Ciao-ting | Assignee: Tci co ltd | IPC: A61K36/00 | Abstract: The present invention provides a method of a composition containing plant extracts for enhancing the gene expression level of TGM1, KRT, AQP3, FLG, GBA, and HAS. Compared to a single plant extract, the combination of the plant extracts of the present invention can more effectively enhance the expression level of skin moisturizing genes. The plant extracts constituting the composition include: an extract of spinach, blueberry, Pu-erh tea, or Four Seasons Spring tea. | |||
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3 | US10933107B2 |
Composition comprising plant extract and use thereof
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Publication/Patent Number: US10933107B2 | Publication Date: 2021-03-02 | Application Number: 16/499,473 | Filing Date: 2018-04-03 | Inventor： Lin, Yung-hsiang Chen, I-hui Kan, Kai-wen Liu, Fu Chen Chen, Ciao-ting | Assignee: Tci co ltd | IPC: A61K36/00 | Abstract: Provided is a composition comprising a plant extract. The plant extract includes a citrus extract and a green tea extract. The extract combination can effectively increase expression of GLUT4 gene. | |||
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4 | US2021000893A1 |
LACTOBACILLUS PLANTARUM STRAIN TCI227 AND USES OF THE LACTOBACILLUS PLANTARUM STRAIN TCI227 FOR REGULATING EXPRESSION OF IL-1BETA GENE, TNF-ALPHA GENE, MMP1a GENE AND TIMP1 GENE, AND TREATING GOUT
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Publication/Patent Number: US2021000893A1 | Publication Date: 2021-01-07 | Application Number: 16/693,758 | Filing Date: 2019-11-25 | Inventor： Lin, Yung-hsiang Huang, Chu-han Ho, Cheng-yu | Assignee: Tci co ltd | IPC: A61K35/747 | Abstract: The present disclosure provides a Lactobacillus plantarum strain and a method for regulating expression of IL-1β gene, TNF-α gene, MMP1α gene and TIMP1 gene, and treating gout using the Lactobacillus plantarum strain. | |||
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5 | US10940174B1 |
Methods for skin whitening, ultraviolet radiation protection and suppression of glycation using green mango extracts and compounds obtained therefrom
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Publication/Patent Number: US10940174B1 | Publication Date: 2021-03-09 | Application Number: 16/561,083 | Filing Date: 2019-09-05 | Inventor： Lin, Yung-hsiang Yu, Chin-hsiu Chung, Yu-ming | Assignee: Tci co ltd | IPC: A61K36/00 | Abstract: Provided is a method for skin whitening, ultraviolet radiation protection, and anti-glycation by using a green mango extract. Also provided is a method for anti-glycation by using compounds of hydrolyzable tannins isolated from the green mango extract. | |||
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6 | US2021069272A1 |
METHODS FOR SKIN WHITENING, ULTRAVIOLET RADIATION PROTECTION AND SUPPRESSION OF GLYCATION USING GREEN MANGO EXTRACTS AND COMPOUNDS OBTAINED THEREFROM
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Publication/Patent Number: US2021069272A1 | Publication Date: 2021-03-11 | Application Number: 16/561,083 | Filing Date: 2019-09-05 | Inventor： Lin, Yung-hsiang Yu, Chin-hsiu Chung, Yu-ming | Assignee: Tci co ltd | IPC: A61K36/22 | Abstract: Provided is a method for skin whitening, ultraviolet radiation protection, and anti-glycation by using a green mango extract. Also provided is a method for anti-glycation by using compounds of hydrolyzable tannins isolated from the green mango extract. | |||
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7 | US2021069223A1 |
USE OF COMPOUND FOR PREVENTING AND/OR TREATING OBESITY
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Publication/Patent Number: US2021069223A1 | Publication Date: 2021-03-11 | Application Number: 17/016,384 | Filing Date: 2020-09-10 | Inventor： Lin, Yung-hsiang | Assignee: Tci co ltd | IPC: A61K31/7048 | Abstract: A method of preventing and/or treating obesity is provided. The method includes administering a composition to a subject, and the composition has at least one compound selected from the group consisting of 4-hydroxy-3-methoxycinnamic acid (also referred to as (E)-3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoic acid), 7-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, and 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one. The compound can effectively promote lipolysis and/or reduce the cell fat content and can effectively reduce the fat content in cells to achieve the purpose of preventing and/or treating obesity. | |||
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8 | US2021046126A1 |
USE OF BACILLUS COAGULANS IN PREPARING COMPOSITIONS FOR SOBERING UP AND FOOD PRODUCT FOR SOBERING UP
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Publication/Patent Number: US2021046126A1 | Publication Date: 2021-02-18 | Application Number: 16/993,284 | Filing Date: 2020-08-14 | Inventor： Chiu, Yu-kai Lin, Yung-hsiang | Assignee: Tci co ltd | IPC: A61K35/742 | Abstract: A use of Bacillus coagulans TCI711 in preparing compositions for sobering up is provided. The Bacillus coagulans TCI711 is deposited in Consortium Food Industry Research and Development Institute (Deposit number: BCRC910807) and German Microbial and Cell Culture Collection Center (DSMZ-DEUTSCHE SAMMLUNG VON MIKROORGANISMEN UND ZELLKULTUREN GmbH) (Deposit number: DSM33163). | |||
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9 | US2021009637A1 |
BIOMIMETIC PEPTIDES DERIVED FROM BIOLOGICAL SOURCE AND THEIR USES IN RETARDING AGING AND IMPROVING SKIN
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Publication/Patent Number: US2021009637A1 | Publication Date: 2021-01-14 | Application Number: 16/702,385 | Filing Date: 2019-12-03 | Inventor： Lin, Yung-hsiang Wang, Yu-ling | Assignee: Tci co ltd | IPC: C07K7/06 | Abstract: The present disclosure provides peptides comprising a motif having four amino acids, wherein each of the amino acids at N-terminus and C-terminus of the sequence independently has a same or different positively charged side chain, and each of the amino acids between the N-terminal and C-terminal of the motif independently has a same or different uncharged side chain. The present disclosure surprisingly found that these peptides have advantageous effects in inhibiting or decreasing collagen breakdown, increasing production of collagen, elastin and/or hyaluronic acid, retarding aging, improving skin and inhibiting inflammation. | |||
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10 | US2021007986A1 |
LIPOSOME COMPOSITION WITH ADIPOCYTE SPECIFICITY AND PREPARATION PROCESS THEREOF
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Publication/Patent Number: US2021007986A1 | Publication Date: 2021-01-14 | Application Number: 16/921,964 | Filing Date: 2020-07-07 | Inventor： Lin, Yung-hsiang Chang, Jung | Assignee: Tci co ltd | IPC: A61K9/127 | Abstract: A liposome composition with adipocyte specificity comprises a shell formed by a liposome material, and a ligand material bound to a surface of the shell. The ligand material is a plurality of long chain fatty acids, and the liposome composition recognizes and binds to an adipocyte by the plurality of long chain fatty acids. | |||
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11 | US10918683B2 |
Methods to reduce fat accumulation and oxidative damage in liver using green mango extracts and compounds obtained therefrom
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Publication/Patent Number: US10918683B2 | Publication Date: 2021-02-16 | Application Number: 16/502,102 | Filing Date: 2019-07-03 | Inventor： Lin, Yung-hsiang Yu, Chin-hsiu Lin, Shan-yu | Assignee: Tci co ltd | IPC: A61K36/00 | Abstract: Provided is a method for reducing fat accumulation in and oxidative damage to liver cells by using a green mango extract. Also provided is a method for reducing fat accumulation in liver cells by using compounds of hydrolyzable tannins isolated from the green mango extract. | |||
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12 | US2021015736A1 |
HALOBACILLUS TRUEPERI TCI66207 AND BACTERIAL LYSATE THEREOF AND USE OF BACTERIAL LYSATE
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Publication/Patent Number: US2021015736A1 | Publication Date: 2021-01-21 | Application Number: 16/932,867 | Filing Date: 2020-07-20 | Inventor： Huang, Chu-han Lin, Yung-hsiang | Assignee: Tci co ltd | IPC: A61K8/99 | Abstract: A Halobacillus trueperi TCI66207 strain, deposited in Non-profit Private Entity Food Industry Research and Development Institute (Deposit number: BCRC910961). The H. trueperi TCI66207 strain has one or more of the following function: improving skin cell mitochondrion activity, promoting skin cell proliferation, maintaining skin corneum layer completeness, increasing expression of cornifin (Keratin14) and/or hyaluronic acid synthase (HAS3) genes and promoting hyaluronic acid production. | |||
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13 | US2021023159A1 |
METHOD FOR PROMOTING GROWTH OF AKKERMANSIA MUCINIPHILA USING MUSA FERMENTS
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Publication/Patent Number: US2021023159A1 | Publication Date: 2021-01-28 | Application Number: 16/727,389 | Filing Date: 2019-12-26 | Inventor： Lin, Yung-hsiang Huang, Chu-han Ho, Cheng-yu | Assignee: Tci co ltd | IPC: A61K36/88 | Abstract: Provided is a method of promoting the growth of Akkermansia muciniphila, including contacting A. muciniphila with an effective amount of a prebiotic composition including a Musa ferment. Also provided is a prebiotic composition including a Musa ferment. The prebiotic composition promotes the growth of A. muciniphila in the intestine, and reduces the body weight, fat percentage, waist circumference, and hip circumference of obese individuals. | |||
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14 | US10905674B2 |
Method of increasing melatonin synthesis to treat insomnia, ameliorate sleep disturbance and regulate sleep
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Publication/Patent Number: US10905674B2 | Publication Date: 2021-02-02 | Application Number: 16/776,190 | Filing Date: 2020-01-29 | Inventor： Lin, Yung-hsiang Yu, Chin-hsiu Su, Yu-hung Lin, Shan-yu Chung, Yu-ming | Assignee: Tci co ltd | IPC: A61K31/122 | Abstract: A method for at least one of increasing the synthesis of melatonin and promoting the secretion of melatonin is provided, wherein the method comprises administering to a subject in need an effective amount of a compound of formula (I): A method for at least one of treating diseases related to neurometabolic disorder, preventing diseases related to neurometabolic disorder, regulating appetite, regulating mood, regulating vasoconstriction, regulating hemostatic function and regulating immune response is also provided, wherein the method comprises administering to a subject in need an effective amount of a compound of formula (I) as described above. | |||
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15 | US10918681B2 |
Method for regulating expression of PDGFC, FGF2, IGF1R, PTGIS, NOS3, EDN1, PLAT, PROC, VWF, F3, SERPINE1, IL-8, ICAM1, VCAM1, and CASP8 genes
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Publication/Patent Number: US10918681B2 | Publication Date: 2021-02-16 | Application Number: 16/498,737 | Filing Date: 2018-04-03 | Inventor： Lin, Yung-hsiang Chen, I-hui Kan, Kai-wen Liu, Fu Chen Chen, Ciao-ting | Assignee: Tci co ltd | IPC: A61K36/00 | Abstract: The present disclosure provides a method for regulating expression of PDGFC, FGF2, IGF1R, PTGIS, NOS3, EDN1, PLAT, PROC, VWF, F3, SERPINE1, IL-8, ICAM1, VCAM1, and CASP8 genes, including administering to a subject in need thereof a composition including an effective amount of a plant extract, wherein the plant extract includes at least one combination selected from the group consisting of a grape seed extract and a Four seasons spring tea extract, a black tea extract and a spinach extract, the grape seed extract and the spinach extract, the grape seed extract and a green coffee bean extract, a red wine extract and a Pu-erh tea extract, and the grape seed extract and the Pu-erh tea extract. | |||
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16 | EP3763225A1 |
BLACK RICE EXTRACT FERMENTS AND THE PREPARATION METHODS AND APPLICATIONS THEREOF
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Publication/Patent Number: EP3763225A1 | Publication Date: 2021-01-13 | Application Number: 20182011.5 | Filing Date: 2020-06-24 | Inventor： Huang, Chu-han Chung, Yu-ming Lin, Yung-hsing | Assignee: Tci co ltd | IPC: A23L33/10 | Abstract: A composition comprising a fermentation product of black rice extract, uses of the fermentation product and its active ingredients, and a method for manufacturing the fermentation product. The fermentation product of black rice extract comprises at least one of the following compounds of formula (I) to formula (V): | |||
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17 | EP3763725A1 |
BIOMIMETIC PEPTIDES DERIVED FROM BIOLOGICAL SOURCE AND THEIR USES IN RETARDING AGING AND IMPROVING SKIN
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Publication/Patent Number: EP3763725A1 | Publication Date: 2021-01-13 | Application Number: 19203345.4 | Filing Date: 2019-10-15 | Inventor： Lin, Yung-hsiang Wang, Yu-ling | Assignee: Tci co ltd | IPC: C07K7/06 | Abstract: The present disclosure provides peptides comprising a motif having four amino acids, wherein each of the amino acids at N-terminus and C-terminus of the sequence independently has a same or different positively charged side chain, and each of the amino acids between the N-terminal and C-terminal of the motif independently has a same or different uncharged side chain. The present disclosure surprisingly found that these peptides have advantageous effects in inhibiting or decreasing collagen breakdown, increasing production of collagen, elastin and/or hyaluronic acid, retarding aging, improving skin and inhibiting inflammation. | |||
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18 | EP3763392A1 |
LIPOSOME COMPOSITION WITH ADIPOCYTE SPECIFICITY AND PREPARATION PROCESS THEREOF
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Publication/Patent Number: EP3763392A1 | Publication Date: 2021-01-13 | Application Number: 20184431.3 | Filing Date: 2020-07-07 | Inventor： Lin, Yung-hsiang Chang, Jung | Assignee: Tci co ltd | IPC: A61K47/69 | Abstract: A liposome composition with adipocyte specificity comprises a shell formed by a liposome material, and a ligand material bound to a surface of the shell. The ligand material is a plurality of long chain fatty acids (11), and the liposome composition recognizes and binds to an adipocyte (21) by the plurality of long chain fatty acids (11). | |||
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19 | US10898429B2 |
Uses of coffee pulp extract
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Publication/Patent Number: US10898429B2 | Publication Date: 2021-01-26 | Application Number: 16/241,722 | Filing Date: 2019-01-07 | Inventor： Lin, Yung-hsiang Li, Zih-yi | Assignee: Tci co ltd | IPC: A61K36/74 | Abstract: A method for at least one of whitening skin, improving skin condition, protecting skin and inhibiting skin aging is provided, wherein the method comprises administering to a subject in need an effective amount of a coffee pulp extract. A method for at least one of repairing skin tissues, preventing skin disease, and treating skin disease is also provided, wherein the method comprises administering to a subject in need an effective amount of a coffee pulp extract. | |||
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20 | US10555984B2 |
Method for increasing expression of PDPRD gene by using peanut skin extract
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Publication/Patent Number: US10555984B2 | Publication Date: 2020-02-11 | Application Number: 15/957,630 | Filing Date: 2018-04-19 | Inventor： Lin, Yung-hsiang Yu, Chih-hsiu | Assignee: Tci co ltd | IPC: A61K36/48 | Abstract: A method for increasing the expression of PTPRD gene is provided, wherein the method comprises administering to a subject in need an effective amount of a peanut skin extract. The method is effective in preventing or treating diseases related to PTPRD gene. |
3.Current Quota