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No. Publication Number Title Publication/Patent Number Publication/Patent Number Publication Date Publication Date
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1
EP3856904A2
METHODS AND COMPOSITIONS FOR SELECTION OF FUNCTIONAL APTAMERS
Publication/Patent Number: EP3856904A2 Publication Date: 2021-08-04 Application Number: 19801089.4 Filing Date: 2019-09-27 Inventor: Amir, Yaniv   Abu-horowitz, Almogit   Bachelet, Ido   Bassali, Liron Anna   Debby, Elinor   Efrati, Liron Levy   Lavi, Erez   Levy, Omer   Kedem, Noam Mamet   Paz, Anastasia   Reiss, Neria   Rusinek, Itai   Scharff, Ye'ela   Skalka, Nir   Assignee: Augmanity Nano Ltd   Aummune Ltd.   IPC: C12N15/11
2
CN109593757B
一种探针及其适用于高通量测序的对目标区域进行富集的方法
Grant
Publication/Patent Number: CN109593757B Publication Date: 2021-08-03 Application Number: 201710918635.3 Filing Date: 2017-09-30 Inventor: 张林华   李旭超   葛会娟   金保雷   陈宁   阮力   郑立谋   Assignee: 厦门艾德生物医药科技股份有限公司   IPC: C12N15/11 Abstract: 本发明公开了一种适用于高通量测序的探针及利用该探针富集目标区域的方法。探针从5’端依次为,连接臂,屏蔽序列1,UID序列1,Illumina Tag1序列,dU区,Illumina Tag2序列,UID序列2,屏蔽序列2,延伸臂;其中屏蔽序列1,屏蔽序列2,dU区,UID序列1,UID序列2可以是0bp。采用本发明的探针构建的文库测序时无需额外添加测序引物,采用本发明的方法可直接以RNA为模板进行目标区域捕获,简化实验流程。
3
EP3765609A1
SYNTHETIC TRANSFER RNA WITH EXTENDED ANTICODON LOOP
Publication/Patent Number: EP3765609A1 Publication Date: 2021-01-20 Application Number: 19710419.3 Filing Date: 2019-03-14 Inventor: Ignatova, Zoya   Torda, Andrew   Matthies, Marco   Assignee: Universität Hamburg   IPC: C12N15/11
4
US2021009995A1
POLYRIBONUCLEOTIDE CONTAINING DEUTERATED NUCLEOTIDES
Publication/Patent Number: US2021009995A1 Publication Date: 2021-01-14 Application Number: 16/969,897 Filing Date: 2019-02-13 Inventor: Rudolph, Carsten   Geiger, Johannes   Hocke, Sandra   Weiss, Ludwig   Assignee: ethris GmbH   IPC: C12N15/11 Abstract: The present disclosure provides polyribonucleotides, in particular polyribonucleotides, which comprise deuterated adenosine, cytidine, guanosine, and/or uridine residues and which show reduced immunogenicity and/or enhanced expression, and methods of using such polyribonucleotides for the therapy of diseases.
5
US2021032620A1
OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
Publication/Patent Number: US2021032620A1 Publication Date: 2021-02-04 Application Number: 16/636,902 Filing Date: 2018-08-07 Inventor: Vargeese, Chandra   Zhong, Zhong   Iwamoto, Naoki   Zhang, Jason Jingxin   Dodart, Jean-cosme   Liu, Yuanjing   Kandasamy, Pachamuthu   Divakaramenon, Sethumadhavan   Lu, Genliang   Marappan, Subramanian   Assignee: WAVE LIFE SCIENCES LTD.   IPC: C12N15/11 Abstract: Among other things, the present disclosure provides oligonucleotides, compositions, and methods thereof. Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, conjugation with additional chemical moieties, and/or stereochemistry [e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)], and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., knockdown ability, stability, delivery, etc. In some embodiments, the oligonucleotides decrease the expression, activity and/or level of a C9orf72 gene, including but not limited to, one comprising a repeat expansion, or a gene product thereof. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions, for example, in treatment of C9orf72-related disorders.
6
EP3786296A1
CRISPR-BASED COMPOSITIONS AND METHODS OF USE
Publication/Patent Number: EP3786296A1 Publication Date: 2021-03-03 Application Number: 20201242.3 Filing Date: 2015-12-18 Inventor: Collingwood, Michael Allen   Jacobi, Ashley Mae   Rettig, Garrett Richard   Schubert, Mollie Sue   Behlke, Mark Aaron   Assignee: Integrated Dna Technologies, Inc.   IPC: C12N15/11 Abstract: This invention pertains to modified compositions for use in CRISPR systems, and their methods of use. In particular, length-modified and chemically-modified forms of crRNA and tracrRNA are described for use as a reconstituted guide RNA for interaction with Cas9 of CRIPSR systems. The resultant length-modified and chemically-modified forms of crRNA and tracrRNA are economical to produce and can be tailored to have unique properties relevant to their biochemical and biological activity in the context of the CRIPSR Cas9 endonuclease system.
7
US2021102200A1
SMALL MOLECULE TARGETED RECRUITMENT OF A NUCLEASE TO RNA
Publication/Patent Number: US2021102200A1 Publication Date: 2021-04-08 Application Number: 17/050,219 Filing Date: 2019-04-24 Inventor: Disney, Matthew D.   Assignee: The Scripps Research Institute   IPC: C12N15/11 Abstract: Provided herein are compounds that selectively bind and cleave RNA. In various embodiments, the disclosure provides chemical compounds effective as ribonuclease targeting chimeras (RIBOTACs), that target the endogenous enzyme RNase L to selectively cleave the RNA in a living cell. These compounds are useful in the treatment of diseases, e.g., the treatment of breast cancer.
8
CN107148476B
头颈部癌症的生物标志物及其使用方法
Grant
Publication/Patent Number: CN107148476B Publication Date: 2021-06-08 Application Number: 201580056428.0 Filing Date: 2015-10-16 Inventor: 世龙·路   约翰·宋   Assignee: 科罗拉多大学董事会法人团体   IPC: C12N15/11 Abstract: 公开了一组诊断性编码微RNA的甲基化基因组基因座(mgmiR)标志物,其在检测头颈部鳞状细胞癌(HNSCC)中显示出了90%的敏感性和100%的特异性。这些结果表示首次采用定量MS‑PCR用于检测mgmiR。此外,该组证实了检测癌症患者旁黏膜中超甲基化的能力,表明其在早期检测上的效用。该组还能够通过采用唾液、血液和FNA组织样品检测癌症。
9
CN108138177B9
Dbait分子与PARP抑制剂的组合用于治疗癌症的用途
Grant
Publication/Patent Number: CN108138177B9 Publication Date: 2021-08-13 Application Number: 201680043049.2 Filing Date: 2016-07-22 Inventor: 玛利亚·迪特雷   威尔·杰德伊   Assignee: 法国居里学院   法国国家科学研究中心   欧恩科斯欧公司   法国国家卫生及研究医学协会   巴黎第十一大学   IPC: C12N15/11 Abstract: 本发明涉及PARP抑制剂与Dbait分子的组合,其用于治疗癌症。
10
US2021261954A1
METHOD FOR GENERATING A GENE EDITING VECTOR WITH FIXED GUIDE RNA PAIRS
Publication/Patent Number: US2021261954A1 Publication Date: 2021-08-26 Application Number: 16/973,011 Filing Date: 2019-06-11 Inventor: Kaulich, Manuel   Dikic, Ivan   Wegner, Martin   Matthess, Yves   Husnjak, Koraljka   Assignee: Johann Wolfgang Goethe-Universitat Frankfurt am Main   IPC: C12N15/11 Abstract: The present invention pertains to a novel method for the generation of a vector construct suitable for gene editing applications which comprises a fixed pair of predetermined expressible guide RNA (gRNA) sequences. The method of the invention allows for an easy construction of such vectors and provides in addition thereto vector libraries for the expression of fixed pairs of gRNAs. The vectors of the invention may be advantageously used to cut out larger genomic DNA sequences, or alternatively, to simultaneously introduce mutations in the genome without a loss or larger genomic sequences. Hence, the system of the invention provides for many molecular genetic approaches for genome alteration.
11
EP3230451B1
PROTECTED GUIDE RNAS (PGRNAS)
Publication/Patent Number: EP3230451B1 Publication Date: 2021-04-07 Application Number: 15819996.8 Filing Date: 2015-12-11 Inventor: Zhang, Feng   Abudayyeh, Omar O.   Dahlman, James E.   Hsu, Patrick   Scott, David A.   Assignee: The Broad Institute, Inc.   Massachusetts Institute of Technology   President and Fellows of Harvard College   IPC: C12N15/11
12
CN108728436B
一种分子标记及其在苹果果实苹果酸含量筛选中的应用
Grant
Publication/Patent Number: CN108728436B Publication Date: 2021-07-16 Application Number: 201711137064.6 Filing Date: 2017-11-16 Inventor: 张新忠   贾东杰   韩振海   申飞   王忆   孙瑞   黄振宇   吴贝   王旋旋   吴婷   员相焱   王吾谦   胡慧瑶   刘丽   陈驰杰   张玖利   张希   许雪峰   Assignee: 中国农业大学   IPC: C12N15/11 Abstract: 本发明公开了一种分子标记及其在苹果果实苹果酸含量筛选中的应用。本发明首先保护一种分子标记,为如下(a1)或(a2)或(a3):(a1)序列1所示的DNA分子;(a2)苹果基因组中MdPP2C‑H磷酸酶基因第2901‑3084位核苷酸;(a3)来源于苹果的与序列1的同源性大于95%、98%或99%的DNA分子。本发明还保护分子标记在预测苹果的酸含量性状中的应用。本发明还保护一种预测苹果的酸含量性状的方法,包括如下步骤:检测待测苹果基于分子标记的基因型,Q8Q8基因型苹果的酸含量>Q8q8基因型苹果的酸含量>q8q8基因型苹果的酸含量。鉴于苹果的童期长、遗传背景复杂等特点,本发明将会在很大程度上提高苹果育种的筛选效率,缩短育种年限。
13
EP3268472B1
A THREE-COMPONENT CRISPR/CAS COMPLEX SYSTEM AND USES THEREOF
Publication/Patent Number: EP3268472B1 Publication Date: 2021-05-05 Application Number: 16713184.6 Filing Date: 2016-03-09 Inventor: Wang, Haoyi   Cheng, Albert   Jillette, Nathaniel   Assignee: The Jackson Laboratory   IPC: C12N15/11
14
EP2314692B1
Methods and compositions for enhancing the efficacy and specificity of RNAi
Publication/Patent Number: EP2314692B1 Publication Date: 2021-02-24 Application Number: 10181632.0 Filing Date: 2004-06-02 Inventor: Zamore, Philip D.   Hutvagner, Gyorgy   Schwarz, Dianne   Simard, Martin   Assignee: University of Massachusetts   IPC: C12N15/11
15
CN107922942B
三组分CRISPR/CAS复合系统及其用途
Grant
Publication/Patent Number: CN107922942B Publication Date: 2021-08-31 Application Number: 201680027107.2 Filing Date: 2016-03-09 Inventor: 王皓毅   A·程   N·吉勒特   Assignee: 杰克逊实验室   IPC: C12N15/11 Abstract: 本文描述的本发明提供了用于在靶DNA的特定位置处组装三元复合物的组合物和试剂。本发明还提供了使用所述复合物以例如标记特定基因组座、调节靶基因的表达或创建基因调控网络的方法。
16
US10927371B2
Cationic siRNAs, synthesis and use for RNA interference
Publication/Patent Number: US10927371B2 Publication Date: 2021-02-23 Application Number: 12/735,595 Filing Date: 2009-01-30 Inventor: Behr, France Jean-paul   Kotera, Mitsuharu   Pfender, Nadege   Remy, Jean-serge   Assignee: Centre National De La Recherche Scientifique (CNRS)   Universite De Strasbourg   Pollyplus Transfection   IPC: C12N15/11 Abstract: The invention relates to cationic siRNAs, characterized in that they are double-stranded RNA fragments, grafted to the ends of which are oligocations, the number of cationic charges grafted being comparable to or greater than that of the anionic charges carried by the internucleoside phosphates of the RNA strands.
17
CN107365770B
针对自噬相关基因Beclin1编码区174-194位点的siRNA序列及其应用
Grant
Publication/Patent Number: CN107365770B Publication Date: 2021-05-18 Application Number: 201710680613.8 Filing Date: 2017-08-10 Inventor: 尚世强   陶然   李伟   刘玉洁   Assignee: 浙江大学   IPC: C12N15/11 Abstract: 本发明提供一种针对自噬相关基因Beclin1编码区174‐194位点的siRNA序列,其核苷酸序列是:5’‐GGAGGAAGAGACTAACTCAGG‐3’。本发明根据siRNA设计原则,选择的siRNA的cDNA序列GC含量为52.4%,对应Beclin1基因编码区的第174‐194位核苷酸。构建针对Beclin1的siRNA真核表达载体,转化大肠杆菌后提取质粒,转染AD293细胞,能有效抑制Beclin1基因的mRNA和蛋白表达水平,可作为人源细胞自噬水平调控的一个有效靶点。应用于人类细胞自噬水平的调控。
18
CN112752844A
用于RNA编辑的人工核酸
Substantial Examination
Publication/Patent Number: CN112752844A Publication Date: 2021-05-04 Application Number: 201880096560.8 Filing Date: 2018-06-29 Inventor: J·维滕格尔   T·斯塔福德   P·瑞安特斯尼格   T·莫克利   Assignee: 蒂宾根大学   IPC: C12N15/11 Abstract: 本发明涉及用于定点编辑目标RNA的人工核酸。具体地,本发明提供了能够通过利用内源性脱氨酶定点编辑内源性转录物的人工核酸。进一步,本发明提供了用于定点编辑目标RNA的人工核酸,其被化学修饰,具体是根据本文所述的修饰模式。本发明还包含编码所述人工核酸的载体和包含所述人工核酸的组合物。此外,本发明提供了人工核酸、组合物或载体用于定点编辑目标RNA或体外诊断的应用。另外,提供了本文所述的人工核酸、组合物或载体用作药物或用于诊断疾病或障碍。
19
CN113166759A
经化学修饰的RNAi构建体及其用途
Public
Publication/Patent Number: CN113166759A Publication Date: 2021-07-23 Application Number: 201980081382.6 Filing Date: 2019-12-09 Inventor: J·k·默里   B·吴   Y·程   B·j·赫伯瑞奇   Assignee: 美国安进公司   IPC: C12N15/11 Abstract: 本发明涉及用于降低靶基因的表达的经化学修饰的RNAi构建体。特别地,本发明涉及并入RNAi构建体以改善体内稳定性和有效性的经修饰的核苷酸的特定模式。还描述了包含该经化学修饰的RNAi构建体的药物组合物和通过施用该经化学修饰的RNAi构建体来抑制体内靶基因表达,例如,以治疗或减轻多种疾病病症的方法。
20
EP3814498A1
ARTIFICIAL NUCLEIC ACIDS FOR RNA EDITING
Publication/Patent Number: EP3814498A1 Publication Date: 2021-05-05 Application Number: 18748858.0 Filing Date: 2018-06-29 Inventor: Wettengel, Jacqueline   Stafforst, Thorsten   Reautschnig, Philipp   Merkle, Tobias   Assignee: Eberhard-Karls-Universität Tübingen   IPC: C12N15/11
Total 500 pages