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1
US2003065160A1
Secreted protein HEMAE80
Publication/Patent Number: US2003065160A1 Publication Date: 2003-04-03 Application Number: 10/004,860 Filing Date: 2001-12-07 Inventor: Young, Paul   Greene, John M.   Ferrie, Ann M.   Ruben, Steven M.   Rosen, Craig A.   Hu, Jing-shan   Olsen, Henrik S.   Ebner, Reinhard   Brewer, Laurie A.   Moore, Paul A.   Shi, Yanggu   Florence, Charles   Florence, Kimberly   Lafleur, David W.   Ni, Jian   Fan, Ping   Wei, Ying-fei   Fischer, Carrie L.   Soppet, Daniel R.   Li, Yi   Zeng, Zhizhen   Kyaw, Hla   Yu, Guo-liang   Feng, Ping   Dillon, Patrick J.   Endress, Gregory A.   Carter, Kenneth C.   Assignee: Human Genome Sciences, Inc.   IPC: C12N009/00 Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
2
US2003065166A1
Process and apparatus for the industrial preparation of methylhydroxyalkylcellulose
Publication/Patent Number: US2003065166A1 Publication Date: 2003-04-03 Application Number: 10/241,711 Filing Date: 2002-09-11 Inventor: Holtkotter, Torsten   Michel, Stefan   Sonnenberg, Gerd   Assignee: Holtkotter, Torsten   Michel, Stefan   Sonnenberg, Gerd   IPC: C08B011/193 Abstract: A description is given of a process for the industrial preparation of methylhydroxyalkylcelluloses (MHACs) by reaction of cellulose with alkali metal hydroxide and subsequent reaction with an alkyl halide and hydroxyalkylating agent, characterized in that the reaction is carried out batchwise in a reactor which has an L/D ratio of less than 2.5 and in which the unmixed regions are minimized and the batch reactor is preceded at the inlet by a continuously operated cellulose milling facility and is followed at the outlet by a continuously running plant for milling and drying the products, with the product being transported by action of gravity. An apparatus for carrying out this process and the methylhydroxyalkylcellulose obtainable by the process are also described.
3
US2003065181A1
Novel chiral phosphorus ligands and the use thereof in the production of optically active products
Publication/Patent Number: US2003065181A1 Publication Date: 2003-04-03 Application Number: 10/062,027 Filing Date: 2002-02-01 Inventor: Leitner, Walter   Francio, Giancarlo   Faraone, Felice   Arena, Carmela   Assignee: Leitner, Walter   Francio, Giancarlo   Faraone, Felice   Arena, Carmela   IPC: C07F009/60 Abstract: The present invention relates to novel chiral phosphorus compounds which can be readily prepared from quinoline derivatives as inexpensive starting compounds and have the general formula I 1 wherein R1, R2, R3, R4, R5 are chiral or achiral organic residues which are derived from substituted or unsubstituted straight or branched chain or cyclic aliphatic or aromatic groups and which, in the case of the pairs R1/R2 and R4/R5, may be interconnected. Further, the invention relates to the use of chiral phosphorus compounds of general formula I as catalysts or catalyst components in processes for the preparation of optically active products.
4
US2003065185A1
Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
Publication/Patent Number: US2003065185A1 Publication Date: 2003-04-03 Application Number: 10/119,238 Filing Date: 2002-04-08 Inventor: Thorsett, Eugene D.   Semko, Christopher M.   Pleiss, Michael A.   Lombardo, Louis John   Grant, Francine S.   Dressen, Darren B.   Dappen, Michael S.   Assignee: Thorsett, Eugene D.   Semko, Christopher M.   Pleiss, Michael A.   Lombardo, Louis John   Grant, Francine S.   Dressen, Darren B.   Dappen, Michael S.   IPC: C07D211/18 Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
5
US2003065095A1
Epoxy resin composition and fiber-reinforced composite material formed with the epoxy resin composition
Publication/Patent Number: US2003065095A1 Publication Date: 2003-04-03 Application Number: 10/148,873 Filing Date: 2002-06-11 Inventor: Kaneko, Takashi   Mitani, Kazutami   Assignee: Kaneko, Takashi   Mitani, Kazutami   IPC: C08F008/00 Abstract: An epoxy resin composition according to the present invention is an epoxy resin composition with a viscosity at 25° C. of no more than 1000 mPa· s, incorporating (A) at least one of a bisphenol type epoxy resin (A1) and a phenol novolak type epoxy resin (A2), a polyvalent epoxy resin formed from a mononuclear aromatic backbone (B) and an aromatic amine curing agent (C), wherein a cured product produced by curing the epoxy resin composition displays a breaking elongation of at least 5%. The epoxy resin composition has a low viscosity at room temperature which can be sustained with good stability for long periods. Furthermore, a cured product produced by curing the epoxy resin composition displays excellent heat resistance and mechanical characteristics, and is consequently ideally suited for use as a matrix resin for fiber reinforced composite materials.
6
US2003065101A1
Silicon-containing acetal protected polymers and photoresists compositions thereof
Publication/Patent Number: US2003065101A1 Publication Date: 2003-04-03 Application Number: 10/116,717 Filing Date: 2002-04-04 Inventor: Blakeney, Andrew J.   Malik, Sanjay   Dilocker, Stephanie   Ferri, John   Eisele, Jeffery   Assignee: ARCH SPECIALITY CHEMICALS, INC.   IPC: C08F030/08 Abstract: A photoresist composition comprising at least one acetal polymer having a silicon substituent; provided that the silicon substituent is not directly attached to the acetal functionality, thereby providing high resolution, improved DOF, and improved dimensional stability under metrology conditions.
7
US2003065116A1
Corrosion inhibiting compositions
Publication/Patent Number: US2003065116A1 Publication Date: 2003-04-03 Application Number: 10/234,917 Filing Date: 2002-09-04 Inventor: Ghosh, Tirthankar   Hann, William M.   Weinstein, Barry   Assignee: Ghosh, Tirthankar   Hann, William M.   Weinstein, Barry   IPC: C08F126/06 Abstract: A new class of polymeric corrosion inhibiting compositions incorporating pendant heterocyclic groups which are surprisingly effective copper corrosion inhibitors are disclosed. The polymers form a protective barrier on metallic components to aqueous systems and remain substantive on metallic surfaces over a wide pH range. Moreover, the polymers are resistant to oxidizing biocides, and are substantially impervious to repeated or prolonged exposure to corrosive agents.
8
US2003065125A1
Monomer-poor polyurethane bonding agent having an improved lubricant adhesion
Publication/Patent Number: US2003065125A1 Publication Date: 2003-04-03 Application Number: 10/137,884 Filing Date: 2002-05-02 Inventor: Bolte, Gerd   Kruedenscheidt, Markus   Assignee: Bolte, Gerd   Kruedenscheidt, Markus   IPC: C08G018/10 Abstract: An isocyanate bonding agent which has a low content of highly volitile residual monomers which forms little migrate and has improved lubricant adhesion is provided. The bonding agent comprises prepolymers having isocyanate groups of different reactivities or the reaction products thereof.
9
US2003065136A1
Compounds and methods for modulating cell adhesion
Publication/Patent Number: US2003065136A1 Publication Date: 2003-04-03 Application Number: 10/105,008 Filing Date: 2002-03-22 Inventor: Blaschuk, Orest W.   Gour, Barbara J.   Farookhi, Riaz   Ali, Anmar   Assignee: McGill University   IPC: A61K038/00 Abstract: Cyclic peptides comprising a cadherin cell adhesion recognition sequence HAV, and compositions comprising such cyclic peptides, are provided. Methods for using such peptides for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.
10
US2003063998A1
Process for inhibiting metallic corrosion in aqueous systems
Publication/Patent Number: US2003063998A1 Publication Date: 2003-04-03 Application Number: 10/234,861 Filing Date: 2002-09-04 Inventor: Ghosh, Tirthankar   Hann, William M.   Weinstein, Barry   Assignee: Ghosh, Tirthankar   Hann, William M.   Weinstein, Barry   IPC: C23F011/14 Abstract: The use of a new class of polymeric corrosion inhibiting compositions incorporating pendant heterocyclic groups is disclosed. The polymers form a protective barrier on metallic components to aqueous systems and remain substantive on metallic surfaces over a wide pH range. Moreover, the polymers are resistant to oxidizing biocides, and are substantially impervious to repeated or prolonged exposure to corrosive agents.
11
US2003064004A1
Rotary drive in an instrument for processing microscale liquid sample volumes
Publication/Patent Number: US2003064004A1 Publication Date: 2003-04-03 Application Number: 10/244,667 Filing Date: 2002-09-17 Inventor: Agren, Tomas   Ostlin, Henrik   Assignee: Agren, Tomas   Ostlin, Henrik   IPC: G01N033/00 Abstract: The invention relates to a rotary drive adapted for creating liquid flow in rotatable microfluidic discs. A rotary drive for spinning a disc shaped substrate having microfluidic structures formed therein for the flow control of microliter and/or nanoliter volumes of liquid by centrifugal force is suggested, comprising a motor with a spindle having an axis of rotation. A rotary member is connected for rotation with the spindle and driven for rotation relative to a stationary member, the rotary member being formed with a top plane having a centering guide for receiving the disc so as to force a symmetry axis of the disc into alignment with said axis of rotation. A vacuum source is connected with the stationary member and communicating with the rotary member or a part thereof rotating with the rotary member for applying sub-pressure to the disc when spinning the disc about its symmetry axis. Preferably, the rotary member is journalled for contact-free rotation relative to the stationary member.
12
US2003064014A1
Purification of gases by pressure swing adsorption
Publication/Patent Number: US2003064014A1 Publication Date: 2003-04-03 Application Number: 09/922,125 Filing Date: 2001-08-03 Inventor: Kumar, Ravi   Deng, Shuguang   Assignee: Kumar, Ravi   Deng, Shuguang   IPC: B01D053/34 Abstract: A process for removing impurities from a gaseous feed stream is disclosed. Impurities such as hydrogen, water, carbon monoxide and carbon dioxide are removed from the gaseous feed stream in a vessel in a reaction zone having layers of adsorbent materials and oxidation catalysts. Preferably, the process is a pressure swing adsorption process prior to a cryogenic distillation unit.
13
US2003064029A1
Engineered particles and methods of use
Publication/Patent Number: US2003064029A1 Publication Date: 2003-04-03 Application Number: 10/096,780 Filing Date: 2002-03-12 Inventor: Tarara, Thomas E.   Weers, Jeffry G.   Kabalnov, Alexey   Schutt, Ernest G.   Dellamary, Luis A.   Assignee: Tarara, Thomas E.   Weers, Jeffry G.   Kabalnov, Alexey   Schutt, Ernest G.   Dellamary, Luis A.   IPC: A61L009/04 Abstract: Engineered particles are provided may be used for the delivery of a bioactive agent to the respiratory tract of a patient. The particles may be used in the form of dry powders or in the form of stabilized dispersions comprising a nonaqueous continuous phase. In particularly preferred embodiments the particles may be used in conjunction with an inhalation device such as a dry powder inhaler, metered dose inhaler or a nebulizer.
14
US2003064033A1
Propellant-based microparticle formulations
Publication/Patent Number: US2003064033A1 Publication Date: 2003-04-03 Application Number: 10/222,200 Filing Date: 2002-08-16 Inventor: Brown, Larry R.   Scott, Terrence L.   Rashba-step, Julia   Mcgeehan, John K.   Assignee: Brown, Larry R.   Scott, Terrence L.   Rashba-step, Julia   Mcgeehan, John K.   IPC: A61L009/04 Abstract: Pulmonary formulations containing microparticles and a propellant are provided. The microparticles, preferably microspheres, contain protein and exhibit a fine particle fraction in the range of 25 to 100%.
15
US2003064037A1
Sunscreen composition
Publication/Patent Number: US2003064037A1 Publication Date: 2003-04-03 Application Number: 10/216,118 Filing Date: 2002-08-09 Inventor: Yamada, Kosaku   Soh, Chieko   Assignee: The Procter & Gamble Company   IPC: A61K007/42 Abstract: Disclosed is a water-in-oil emulsified sunscreen composition comprising by weight: (a) an effective amount of a UV protection agent; (b) from about 0.1% to about 70% of a non-thickening oil absorbing powder having a mineral oil absorbing ability of at least about 40 ml/100 g; (c) at least about 10% of the entire composition of water; and (d) an oil phase comprising: (i) at least about 50% by weight of the oil phase of a volatile silicone oil; and (ii) from about 0.1% to less than the oil absorbing ability of the non-thickening oil absorbing powder of a non-volatile oil; wherein when the UV protection agent is a non-volatile liquid of hydrophobic nature, it is considered the non-volatile oil.
16
US2003064052A1
Compositions for protein delivery via the pulmonary route
Publication/Patent Number: US2003064052A1 Publication Date: 2003-04-03 Application Number: 10/153,422 Filing Date: 2002-05-21 Inventor: Waters, Michael John   Mahler, Stephen Michael   Chan, Hak-kim   Goodall, Stephen Francis   Chew, Nora Y.k.   Assignee: Ponwell Enterprises, Ltd.   IPC: A61K038/28 Abstract: Novel formulations comprising therapeutic agents, a surface tension-controlling agent, and a component that comprises both a humectant and a viscosity-controlling agent for use in thermal droplet ejecting devices are disclosed. The formulations are useful for maintaining controlled and reliable dosage of the therapeutic agent via pulmonary delivery.
17
US2003064060A1
Mixture of bacillus thuringiensis subspecies israelensis and bacillus sphaericus for management of resistance to mosquito larvicides
Publication/Patent Number: US2003064060A1 Publication Date: 2003-04-03 Application Number: 10/074,782 Filing Date: 2002-02-13 Inventor: Dechant, Peter   Devisetty, Bala N.   Assignee: Dechant, Peter   Devisetty, Bala N.   IPC: A01N063/00 Abstract: A method for controlling Dipteran larvae or a method for inhibiting the development of larvicidal resistance, controlling resistant populations and reducing resistance levels in Diptera by introducing a larvicidally-effective amount of a combination of a strain of Bacillus thuringiensis subspecies israelensis and a strain of Bacillus sphaericus into an environment containing Dipteran larvae; and a composition of the combination are disclosed. Preferably both strains are non-genetically modified.
18
US2003063614A1
Method and apparatus for storing routes for groups of related net configurations
Publication/Patent Number: US2003063614A1 Publication Date: 2003-04-03 Application Number: 10/039,586 Filing Date: 2002-01-04 Inventor: Teig, Steven   Ganley, Joseph L.   Assignee: Teig, Steven   Ganley, Joseph L.   IPC: H04L012/28 Abstract: Some embodiments of the invention provide a method that pre-computes routes for groups of related net configurations. These routes are used by a router that uses a set of partitioning lines to partition a region of a design layout into a plurality of sub-regions. The method identifies groups of related sub-region configurations. For each group, the method stores a base set of routes. For each configuration in each group, the method also stores an indicia that specifies how to obtain a related set of routes for the particular configuration from the base set of routes stored for the configuration's group.
19
US2003063624A1
Call admission control methods and apparatus for improving route selection in packet networks
Publication/Patent Number: US2003063624A1 Publication Date: 2003-04-03 Application Number: 10/264,415 Filing Date: 2002-10-04 Inventor: Nagarajan, Ramesh   Wang, Yung-terng   Assignee: Lucent Technologies Inc.   IPC: H04J003/16 Abstract: A packet switch is configured for determining an equivalent bandwidth for use in GCAC. The equivalent bandwidth definition of the invention is derived by multiplying some known connection parameter such as, for example, a selected bandwidth value by a multiplier preferably computed and stored in look-up tables according to the invention. The appropriate multiplier for a given connection request associated with a call may then be found by accessing sets of the look-up tables based on one or more connection and/or network parameters. For each link in a path considered during GCAC, the product of the multiplication of the selected bandwidth value and the multiplier is then compared to the available bandwidth, AvCR, of the path links to determine if the path satisfies the connection request.
20
US2003063634A1
Laser light sources having integrated detector and intensity control and methods of producing same
Publication/Patent Number: US2003063634A1 Publication Date: 2003-04-03 Application Number: 09/970,073 Filing Date: 2001-10-02 Inventor: Lehman, John A.   Johnson, Klein L.   Fritz, Bernard S.   Bauhahn, Paul E.   Galarneau, Lynn M.   Assignee: Honeywell International Inc.   IPC: H01S005/02 Abstract: A device to monitor light output from a light source, including a V-groove substrate with a reflective coating deposited on at least one surface, an optical fiber, a light source positioned so that an amount of the light emitted, which is less than 100%, enters the optical fiber, a light intensity or source detector positioned so that at least some of the light emitted from the light source, that did not enter the optical fiber impinges upon the light intensity detector, and feedback circuitry. A method of producing a device including the steps of coating a surface of a V-groove substrate with a reflective material, placing a light source in said V-groove substrate. A method of producing a device comprising the steps of coating a surface of a V-groove substrate with a reflective material, placing a light source in said V-groove substrate, placing a light intensity detector in said V-groove substrate, and placing a wave guide structure in said V-groove substrate wherein said reflective material, said light source, said detector and said wave guide structure are positioned in said V-groove substrate so that an amount of light emitted from said light source, which is less than 100%, enters said wave guide structure; and at least some of the light emitted from said light source, that did not enter said wave guide structure reflects from said reflective material and impinges upon said light intensity detector.
Total 500 pages