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1
US20190185864A1
Publication/Patent Number: US20190185864A1
Publication date: 2019-06-20
Application number: 16/327,396
Filing date: 2017-08-23
Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject. Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing ...more ...less
2
GB201802864D0
Publication/Patent Number: GB201802864D0
Publication date: 2018-04-11
Application number: 201802864
Filing date: 2018-02-22
Inventor:
IPC:
3
WO2018039375A1
Publication/Patent Number: WO2018039375A1
Publication date: 2018-03-01
Application number: 2017048257
Filing date: 2017-08-23
Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject. Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing ...more ...less
4
US9593148B2
Publication/Patent Number: US9593148B2
Publication date: 2017-03-14
Application number: 14/438,107
Filing date: 2013-10-31
Abstract: The present invention relates to non-competitive allosteric peptide inhibitors of DPP9 and/or DPP8, competitive peptides binding to SUMO1, nucleic acid molecules and expression vectors coding said peptide inhibitors, host cells expressing said inhibitors, kits comprising said inhibitors, as well as methods of producing said inhibitors, and uses of said peptide inhibitors; as further defined in the Claims. The present invention relates to non-competitive allosteric peptide inhibitors of DPP9 and/or DPP8, competitive peptides binding to SUMO1, nucleic acid molecules and expression vectors coding said peptide inhibitors, host cells expressing said inhibitors, kits comprising said ...more ...less
5
CA2987704A1
Publication/Patent Number: CA2987704A1
Publication date: 2016-12-22
Application number: 2987704
Filing date: 2016-06-03
Abstract: A method of operating a multi-functional limb movement auxiliary device comprising a plurality of actuators configured to move
6
US9068002B2
Publication/Patent Number: US9068002B2
Publication date: 2015-06-30
Application number: 12/295,718
Filing date: 2007-04-02
Abstract: The invention relates to the use of an antibody which can specifically bind to chemokine receptor CCR2 for producing a medicament utilized for the treatment of multiple sclerosis and/or rheumatoid arthritis in a subject that is preferably a primate or a human. In another embodiment, the invention relates to the use of an antibody which can specifically bind to chemokine receptor CCR2 for producing a medicament that is utilized for depleting monocytes in subjects suffering from multiple sclerosis and/or rheumatoid arthritis. The invention further relates to corresponding in vitro methods and therapeutic methods. And antibody which binds to CD 14, for example, can be used in addition to the antibody that can bind to CCR2. The invention relates to the use of an antibody which can specifically bind to chemokine receptor CCR2 for producing a medicament utilized for the treatment of multiple sclerosis and/or rheumatoid arthritis in a subject that is preferably a primate or a human. In another ...more ...less
7
US20150266922A1
Publication/Patent Number: US20150266922A1
Publication date: 2015-09-24
Application number: 14/438,107
Filing date: 2013-10-31
Abstract: The present invention relates to non-competitive allosteric peptide inhibitors of DPP9 and/or DPP8, competitive peptides binding to SUMO1, nucleic acid molecules and expression vectors coding said peptide inhibitors, host cells expressing said inhibitors, kits comprising said inhibitors, as well as methods of producing said inhibitors, and uses of said peptide inhibitors; as further defined in the Claims. The present invention relates to non-competitive allosteric peptide inhibitors of DPP9 and/or DPP8, competitive peptides binding to SUMO1, nucleic acid molecules and expression vectors coding said peptide inhibitors, host cells expressing said inhibitors, kits comprising said ...more ...less
8
GB201515223D0
Publication/Patent Number: GB201515223D0
Publication date: 2015-10-14
Application number: 201515223
Filing date: 2015-08-27
Inventor:
IPC:
9
TW201509796A
Publication/Patent Number: TW201509796A
Publication date: 2015-03-16
Application number: 103116367
Filing date: 2014-05-08
Abstract: The present invention relates to a graphene film
11
ES2446093T3
Publication/Patent Number: ES2446093T3
Publication date: 2014-03-06
Application number: 07820865
Filing date: 2007-10-02
Abstract: Placa de virutas y/o de fibras
12
ES2441253T3
Publication/Patent Number: ES2441253T3
Publication date: 2014-02-03
Application number: 07846655
Filing date: 2007-11-19
Abstract: Un procedimiento ex vivo para diagnosticar diferencialmente demencias vasculares
13
CA2871683A1
Publication/Patent Number: CA2871683A1
Publication date: 2013-10-31
Application number: 2871683
Filing date: 2013-04-26
Abstract: The invention relates to a method for specifically detecting and optionally for quantifying Mycobacterium avium ssp. paratuberculosis (MAP) in a sample of an individual. According to the method according to the invention
14
US8568895B2
Publication/Patent Number: US8568895B2
Publication date: 2013-10-29
Application number: 13/446,131
Filing date: 2012-04-13
Abstract: The present invention relates to the use of popcorn as material that provides structure and that stabilizes dimensions, for lignocellulose-containing molded articles, such as wood/composite materials, and also to the use of popcorn as binder for formaldehyde in wood/composite materials. The present invention relates to the use of popcorn as material that provides structure and that stabilizes dimensions, for lignocellulose-containing molded articles, such as wood/composite materials, and also to the use of popcorn as binder for formaldehyde in wood/composite ...more ...less
15
US8394639B2
Publication/Patent Number: US8394639B2
Publication date: 2013-03-12
Application number: 12/504,429
Filing date: 2009-07-16
Abstract: The invention provides methods and kits for diagnosing a renal disease in a patient or for predicting the risk of a patient for developing a renal disease. In one embodiment, the invention provides a method for diagnosing a renal disease in a patient, comprising determining the level of a ubiquitin fragment having a mass-to-charge ratio (m/z) of 6188 (ubiquitin m/z 6188), or the level of a nucleic acid encoding ubiquitin m/z 6188, in a sample derived from said patient, wherein the substantial absence or a reduced level of less than 25% of ubiquitin m/z 6188 or the nucleic acid encoding ubiquitin m/z 6188 compared to a control is indicative of the renal disease in said patient. The invention provides methods and kits for diagnosing a renal disease in a patient or for predicting the risk of a patient for developing a renal disease. In one embodiment, the invention provides a method for diagnosing a renal disease in a patient, comprising determining the ...more ...less
16
AU2007321841B2
Publication/Patent Number: AU2007321841B2
Publication date: 2013-07-04
Application number: 2007321841
Filing date: 2007-11-19
Abstract: In an ex vivo method of differentially diagnosing dementias which include vascular dementias and/or frontotemporal lobe degenerations at least one carboxy-terminally truncated amyloid β peptide selected from the group consisting of Aβ1 -38
17
US8362414B2
Publication/Patent Number: US8362414B2
Publication date: 2013-01-29
Application number: 12/669,141
Filing date: 2008-07-14
Abstract: The invention relates to a method and an apparatus for providing a sample for a subsequent analysis of the sample, particularly for analyzing biomolecules, comprising the following steps: generating a free micro liquid jet in an environment having a predetermined pressure, wherein the micro liquid jet contains a carrier liquid and the sample to be analyzed, and dispersing the micro liquid jet into droplets containing the sample, wherein the environment surrounding the micro liquid jet is a gaseous environment in which the pressure is above vacuum conditions. The invention relates to a method and an apparatus for providing a sample for a subsequent analysis of the sample, particularly for analyzing biomolecules, comprising the following steps: generating a free micro liquid jet in an environment having a predetermined pressure ...more ...less
18
US20120196120A1
Publication/Patent Number: US20120196120A1
Publication date: 2012-08-02
Application number: 13/446,131
Filing date: 2012-04-13
Abstract: The present invention relates to the use of popcorn as material that provides structure and that stabilizes dimensions, for lignocellulose-containing molded articles, such as wood/composite materials, and also to the use of popcorn as binder for formaldehyde in wood/composite materials. The present invention relates to the use of popcorn as material that provides structure and that stabilizes dimensions, for lignocellulose-containing molded articles, such as wood/composite materials, and also to the use of popcorn as binder for formaldehyde in wood/composite ...more ...less
19
US8168303B2
Publication/Patent Number: US8168303B2
Publication date: 2012-05-01
Application number: 12/444,513
Filing date: 2007-10-02
Abstract: The present invention relates to the use of popcorn as material that provides structure and that stabilizes dimensions, for lignocellulose-containing molded articles, such as wood/composite materials, and also to the use of popcorn as binder for formaldehyde in wood/composite materials. The present invention relates to the use of popcorn as material that provides structure and that stabilizes dimensions, for lignocellulose-containing molded articles, such as wood/composite materials, and also to the use of popcorn as binder for formaldehyde in wood/composite ...more ...less
20
ES2393418T3
Publication/Patent Number: ES2393418T3
Publication date: 2012-12-21
Application number: 06792191
Filing date: 2006-09-20
Abstract: Sistema de desinfección que comprende (i) al menos una primera cámara (3