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1
US10377991B2
Publication/Patent Number: US10377991B2
Publication date: 2019-08-13
Application number: 15/558,670
Filing date: 2016-03-18
Abstract: This invention provides a method for stably producing airway epithelial cells from pluripotent stem cells. Specifically, the invention relates to a method for producing airway epithelial cells from pluripotent stem cells comprising steps: (1) culturing pluripotent stem cells in a medium containing activin A and a GSK3β inhibitor; (2) culturing the cells obtained in Step (1) in a medium containing a BMP inhibitor and a TGFβ inhibitor; (3) culturing the cells obtained in Step (2) in a medium containing BMP4, retinoic acid, and a GSK3β inhibitor; (5) subjecting the cells obtained after Step (3) to three-dimensional culture in a medium containing a GSK3β inhibitor, FGF10, and a ROCK inhibitor; and (6) subjecting the proximal airway epithelial progenitor cells obtained in Step (5) to three-dimensional culture in a medium containing a ROCK inhibitor. This invention provides a method for stably producing airway epithelial cells from pluripotent stem cells. Specifically, the invention relates to a method for producing airway epithelial cells from pluripotent stem cells comprising steps: (1) culturing pluripotent stem cells in ...more ...less
2
US2019255182A1
Publication/Patent Number: US2019255182A1
Publication date: 2019-08-22
Application number: 15/549,487
Filing date: 2016-02-12
Abstract: The present invention provides: a histone modification control agent for activating expression of a specific gene, i.e., a complex including a histone acetylation enzyme activator useful as an agent for activating a specific gene, and a polyamide for recognizing a regulatory region of a target gene; and a method for manufacturing the same. This complex specifically activates a group of genes relating to maintenance and/or differentiation of stem cells or precursor cells. The present invention provides: a histone modification control agent for activating expression of a specific gene, i.e., a complex including a histone acetylation enzyme activator useful as an agent for activating a specific gene, and a polyamide for recognizing a regulatory ...more ...less
3
US2019172577A1
Publication/Patent Number: US2019172577A1
Publication date: 2019-06-06
Application number: 16/323,766
Filing date: 2017-06-27
Abstract: A dissection process estimation device is configured from: a surgery process case database storing case data of surgery processes describing information relating to dissection surfaces corresponding to dissection sites of target organs and progress of dissection; a standard dissection process generation unit that reads out case data corresponding to a site to be dissected designated by a user from the surgery process case database and generates a standard dissection surface and a standard dissection process based on plural pieces of read case data; an anatomical reference point extraction unit that extracts an anatomical reference point from patient-specific three-dimensional medical image data; and a patient-specific dissection process estimation unit that performs matching of the standard dissection surface and the standard dissection process with the patient-specific three-dimensional medical image data and estimates a patient-specific dissection surface and a patient-specific dissection process. A dissection process estimation device is configured from: a surgery process case database storing case data of surgery processes describing information relating to dissection surfaces corresponding to dissection sites of target organs and progress of dissection; a standard ...more ...less
4
US2019067910A1
Publication/Patent Number: US2019067910A1
Publication date: 2019-02-28
Application number: 16/080,528
Filing date: 2017-02-13
Abstract: A thermal radiation light source includes a laminated body including m quantum layers laminated where m is an integer of 2 or more, including an n-layer and a p-layer sandwiching the quantum layers from both sides in the laminating direction, the n-layer made of an n-type semiconductor and the p-layer made of a p-type semiconductor; a voltage applying unit for the m quantum layers is directly or indirectly connected to the n-layer and p-layer sandwiching each layer applying a voltage for moving to the n-layers or p-layers a charge; a voltage switching unit switches ON/OFF of application of the voltage to the m quantum layers; and a photonic crystal portion disposed in the laminated body or adjacent to the laminated body, so that lights of m wavelengths resonate, the lights of the m wavelengths generated in the m quantum layers corresponding to transition energy between subbands in the quantum layer. A thermal radiation light source includes a laminated body including m quantum layers laminated where m is an integer of 2 or more, including an n-layer and a p-layer sandwiching the quantum layers from both sides in the laminating direction, the n-layer made of an n-type ...more ...less
5
US2019225634A1
Publication/Patent Number: US2019225634A1
Publication date: 2019-07-25
Application number: 16/333,084
Filing date: 2017-09-12
Abstract: Provided is a method for separating the four optical isomers of Nahlsgen. The method according to the present invention for producing a mixture of a D-2-amino-4-[(Rp)-(3-carboxymethylphenoxy)(methoxy)phosphoryl]butanoic acid hydrate and an L-2-amino-4-[(Sp)-(3-carboxymethylphenoxy)(methoxy)phosphoryl]butanoic acid hydrate includes subjecting a mixture of the four optical isomers, represented by Formula (1′), to fractional crystallization from water or from a solvent mixture of water and a water-soluble organic solvent, to precipitate a mixture of a compound represented by Formula (1-1′-1) and a compound represented by Formula (1-4′-1), where Formulae (1′), (1-1′-1), and (1-4′-1) are expressed as follows: Provided is a method for separating the four optical isomers of Nahlsgen. The method according to the present invention for producing a mixture of a D-2-amino-4-[(Rp)-(3-carboxymethylphenoxy)(methoxy)phosphoryl]butanoic acid hydrate and an ...more ...less
6
US10196609B2
Publication/Patent Number: US10196609B2
Publication date: 2019-02-05
Application number: 14/772,991
Filing date: 2014-02-05
Abstract: The present invention provides a composition for promoting cardiac differentiation of a pluripotent stem cell containing an EGFR inhibitor. The present invention also provides a kit for promoting cardiac differentiation containing an EGFR inhibitor and a method for inducing cardiac differentiation of a pluripotent stem cell comprising culturing the pluripotent stem cell in a medium containing an EGFR inhibitor. The present invention provides a composition for promoting cardiac differentiation of a pluripotent stem cell containing an EGFR inhibitor. The present invention also provides a kit for promoting cardiac differentiation containing an EGFR inhibitor and a method for inducing ...more ...less
7
US2019256866A1
Publication/Patent Number: US2019256866A1
Publication date: 2019-08-22
Application number: 16/313,322
Filing date: 2017-06-27
Abstract: An mRNA forcibly expresses a protein gene in response to a miRNA, and a method for forcibly expressing the same, are provided. An artificial mRNA comprising a sequence encoding a protein gene, a miRNA target sequence linked to the 3′-terminal side of a Poly A sequence, and a translational repression sequence linked to the 3′-terminal side of the miRNA target sequence; and a method for expressing a protein gene in response to the expression of a miRNA, comprising a step of introducing the artificial mRNA into a cell. An mRNA forcibly expresses a protein gene in response to a miRNA, and a method for forcibly expressing the same, are provided. An artificial mRNA comprising a sequence encoding a protein gene, a miRNA target sequence linked to the 3′-terminal side of a Poly A sequence ...more ...less
8
US2019010467A1
Publication/Patent Number: US2019010467A1
Publication date: 2019-01-10
Application number: 16/130,528
Filing date: 2018-09-13
Abstract: Provided is a method for preparing cultured cells or tissues for transplantation, comprising at least one of the following steps 1) and 2): 1) when the cultured cells or tissues do not express an HLA-C molecule of at least one HLA-C groups expressed in the receipient's HLA-C locus, forcing the expression of an HLA-C molecule of said HLA-C group in the cultured cells or tissues, or 2) when the cultured cells or tissues are negative or weakly positive for HLA-Bw4 while the recipient is positive for HLA-Bw4, forcing the expression of an HLA molecule of HLA-Bw4 group in the cultured cells or tissues. Provided is a method for preparing cultured cells or tissues for transplantation, comprising at least one of the following steps 1) and 2): 1) when the cultured cells or tissues do not express an HLA-C molecule of at least one HLA-C groups expressed in the receipient's HLA-C ...more ...less
9
US10295528B2
Publication/Patent Number: US10295528B2
Publication date: 2019-05-21
Application number: 15/301,762
Filing date: 2015-04-07
Abstract: The present invention relates to a method for screening an inhibitor of ATP11C or CDC50A, comprising determining (a) exposure of phosphatidylserine on cell surface, (b) engulfment of cells by macrophages, or (c) cleavage of ATP11C by caspase. The present invention also relates to a method for inducing engulfment of cells by macrophages, comprising inhibiting ATP11C or CDC50A. The present invention relates to a method for screening an inhibitor of ATP11C or CDC50A, comprising determining (a) exposure of phosphatidylserine on cell surface, (b) engulfment of cells by macrophages, or (c) cleavage of ATP11C by caspase. The present invention also relates ...more ...less
10
US10385407B2
Publication/Patent Number: US10385407B2
Publication date: 2019-08-20
Application number: 15/909,666
Filing date: 2018-03-01
Abstract: The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers.
11
US2019139662A1
Publication/Patent Number: US2019139662A1
Publication date: 2019-05-09
Application number: 16/096,434
Filing date: 2017-02-20
Inventor: Mori, Yoshiharu  
Abstract: Provided is a long-lived fission product (LLFP) processing method using neutrons that enables generation of high-intensity neutrons using only an accelerator without a fast-neutron reactor or an accelerator-driven nuclear reactor and thereby enables efficient nuclear transmutation of long-lived fission products. In the processing method, neutron-containing primary particles such as deuterons are accelerated under specific conditions inside an FFAG accelerator (10) and are caused to collide with a plate-shaped target (18) to generate high-energy first neutrons that form a beam in a single direction through the break-up of the primary particles and low-energy diffuse second neutrons through excitation of atomic nuclei in the plate-shaped target. A first LLFP (20) is located in the direction of travel of the beam of the first neutrons and a second LLFP (24) is located in proximity to the plate-shaped target (18). Provided is a long-lived fission product (LLFP) processing method using neutrons that enables generation of high-intensity neutrons using only an accelerator without a fast-neutron reactor or an accelerator-driven nuclear reactor and thereby enables efficient nuclear ...more ...less
12
US2019242873A1
Publication/Patent Number: US2019242873A1
Publication date: 2019-08-08
Application number: 16/364,813
Filing date: 2019-03-26
Abstract: The present invention relates to a method for screening an inhibitor of ATP11C or CDC50A, comprising determining (a) exposure of phosphatidylserine on cell surface, (b) engulfment of cells by macrophages, or (c) cleavage of ATP11C by caspase. The present invention also relates to a method for inducing engulfment of cells by macrophages, comprising inhibiting ATP11C or CDC50A. The present invention relates to a method for screening an inhibitor of ATP11C or CDC50A, comprising determining (a) exposure of phosphatidylserine on cell surface, (b) engulfment of cells by macrophages, or (c) cleavage of ATP11C by caspase. The present invention also relates ...more ...less
13
US10435738B2
Publication/Patent Number: US10435738B2
Publication date: 2019-10-08
Application number: 15/110,516
Filing date: 2015-01-09
Abstract: Interaction with a protein is detected by using an RNA probe containing the following sequences; (i) a complementary strand sequence to a DNA barcode sequence, (ii) a sequence of a first stem portion, (iii) a sequence of a second stem portion complementary to the first stem portion for hybridizing with the first stem portion to form a double-stranded stem, and (iv) a sequence of a loop portion contained in RNA for linking the first and second stem portions. Interaction with a protein is detected by using an RNA probe containing the following sequences; (i) a complementary strand sequence to a DNA barcode sequence, (ii) a sequence of a first stem portion, (iii) a sequence of a second stem ...more ...less