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1
US20190017118A1
Publication/Patent Number: US20190017118A1
Publication date: 2019-01-17
Application number: 15/780,573
Filing date: 2016-12-01
Abstract: The invention concerns a method of in vitro or ex vivo evaluation of the risk of complications in a patient who has sustained an insult or an infection generating a systemic inflammatory response syndrome, the method being characterized in that it comprises the step of detecting, in a biological sample obtained from said patient, at least one transcript of the IL7R gene, as well as measuring, in vitro or ex vivo, the quantity of at least one transcript of the IL7R gene, in a biological sample from a patient who has sustained an insult or an infection generating a systemic inflammatory response syndrome, in order to evaluate the risk of complications, and in particular of mortality, in said patient. The invention also concerns kits for measuring, in vitro or ex vivo, the quantity of at least one transcript of the IL7R gene in a biological sample. The invention concerns a method of in vitro or ex vivo evaluation of the risk of complications in a patient who has sustained an insult or an infection generating a systemic inflammatory response syndrome, the method being characterized in that it comprises the step of ...more ...less
2
US20190076484A1
Publication/Patent Number: US20190076484A1
Publication date: 2019-03-14
Application number: 15/762,775
Filing date: 2016-09-23
Abstract: The present invention relates to the use of at least one biomarker for predicting the severity of a disease caused by the infection of an individual with an influenza virus, wherein said biomarker is selected in a group comprising (i) the alpha diversity value of the microbiome present in a respiratory sample of said individual and (ii) the microbiome profile of the said respiratory sample. The present invention relates to the use of at least one biomarker for predicting the severity of a disease caused by the infection of an individual with an influenza virus, wherein said biomarker is selected in a group comprising (i) the alpha diversity value of the microbiome ...more ...less
3
US20190011343A1
Publication/Patent Number: US20190011343A1
Publication date: 2019-01-10
Application number: 16/067,578
Filing date: 2016-12-29
Inventor: Bellon, Ludovic  
Abstract: A method for estimating a stiffness of a deformable part of a system including a four-photodiode detector for analyzing at least one characteristic of a sample. The method includes receiving the signals recorded by the four photodiodes, calculating the resultant signals from the recorded signals, calculating a cross-correlation of the resultant signals calculated for obtaining an intercorrelated signal, estimating the stiffness of the deformable part depending on the intercorrelated signal. A method for estimating a stiffness of a deformable part of a system including a four-photodiode detector for analyzing at least one characteristic of a sample. The method includes receiving the signals recorded by the four photodiodes, calculating the resultant signals from the ...more ...less
4
US10168327B2
Publication/Patent Number: US10168327B2
Publication date: 2019-01-01
Application number: 14/375,623
Filing date: 2013-02-01
Abstract: The present invention relates to the field of medicine, in particular of research and diagnosis. It relates more particularly to a novel tool for detecting antibodies in a biological sample originating from a mammal. This tool, which is in the form of a protein chip, can be used in screening for new targets of interest involved in the occurrence of an autoimmune disease, in particular of a disease affecting the nervous system of a mammal, and also in the diagnosis or the monitoring of the progression of such an autoimmune disease. The invention also relates to a method for producing such a tool and also to kits comprising it and enabling its use. The present invention relates to the field of medicine, in particular of research and diagnosis. It relates more particularly to a novel tool for detecting antibodies in a biological sample originating from a mammal. This tool, which is in the form of a protein chip, can be used ...more ...less
5
US10196488B2
Publication/Patent Number: US10196488B2
Publication date: 2019-02-05
Application number: 15/523,503
Filing date: 2015-11-06
Abstract: The invention relates to a crosslinkable composition X, comprising: at least one organopolysiloxane compound A comprising, per molecule, at least two C2-C6 alkenyl radicals bonded to silicon atoms; at least one organohydrogenopolysiloxane compound B comprising, per molecule, at least two hydrogen atoms bonded to an identical or different silicon atom; at least one catalyst C which is a complex corresponding to the following formula: [Co (L1)2] in which: the symbol Co represents cobalt at degree of oxidation II; the symbols L1, which may be identical or different, represent a ligand which is a β-dicarbonylato anion or the enolate anion of a β-dicarbonylated compound; optionally at least one adhesion promoter D; and optionally at least one filler E. The invention also relates to the use of the previously described catalyst C as silicone composition crosslinking catalyst, to a silicone composition crosslinking method, characterized in that it consists in heating the composition X to a temperature of between 70 and 200° C., and to the resulting crosslinked silicone material Y. The invention relates to a crosslinkable composition X, comprising: at least one organopolysiloxane compound A comprising, per molecule, at least two C2-C6 alkenyl radicals bonded to silicon atoms; at least one organohydrogenopolysiloxane compound B comprising, per molecule, at ...more ...less
6
US20190010413A1
Publication/Patent Number: US20190010413A1
Publication date: 2019-01-10
Application number: 16/068,258
Filing date: 2017-01-12
Abstract: The use, as markers of petroleum products, crude oils, biofuels or lubricants, of rare earth complexes or one of the constituents thereof chosen from rare earth ligands or salts, being capable of forming a rare earth complex after the addition of a developing solution. Preferably, the rare earth complex can be detected by time-resolved fluorescence. Also, a marking method and a method for detecting a rare earth complex as a marker of petroleum products, crude oils, biofuels or lubricants. The use, as markers of petroleum products, crude oils, biofuels or lubricants, of rare earth complexes or one of the constituents thereof chosen from rare earth ligands or salts, being capable of forming a rare earth complex after the addition of a developing solution ...more ...less
7
US20190058031A1
Publication/Patent Number: US20190058031A1
Publication date: 2019-02-21
Application number: 16/080,279
Filing date: 2017-02-23
Abstract: A support for a semiconductor structure includes a charge-trapping layer on a base substrate. The charge-trapping layer consists of a polycrystalline main layer and, interposed in the main layer or between the main layer and the base substrate, at least one intermediate polycrystalline layer composed of a silicon and carbon alloy or carbon. The intermediate layer has a resistivity greater than 1000 ohm·cm. A support for a semiconductor structure includes a charge-trapping layer on a base substrate. The charge-trapping layer consists of a polycrystalline main layer and, interposed in the main layer or between the main layer and the base substrate, at least one intermediate ...more ...less
8
EP3425386A1
Publication/Patent Number: EP3425386A1
Publication date: 2019-01-09
Application number: 17180388.5
Filing date: 2017-07-07
Abstract: The present invention relates to an apparatus and a method for separating and analyzing molecules, in particular proteins such as ADCs. To answer ADCs requirements, the apparatus and the method of the present invention are based on the direct connection between non-denaturing chromatography selected from hydrophobic interaction chromatography, size exclusion chromatography and ion exchange chromatography, size exclusion chromatography and non-denaturing mass spectrometry to answer ADCs requirements. The present invention relates to an apparatus and a method for separating and analyzing molecules, in particular proteins such as ADCs. To answer ADCs requirements, the apparatus and the method of the present invention are based on the direct connection between non-denaturing ...more ...less
9
US10179929B2
Publication/Patent Number: US10179929B2
Publication date: 2019-01-15
Application number: 15/320,448
Filing date: 2015-06-24
Abstract: The invention provides probes with formula (I): in which: X1═NH, O, or S; X2═O or S; SE is a labile group, which may be eliminated under the action of a stimulus that may in particular be the presence of an enzyme, a chemical compound, or a physicochemical characteristic of the medium in which the probe is located; A is an aromatic group that, following cleavage of the C(X2)—O bond in aqueous solution, leads to the liberation of a chromophore or a fluorophore, R represents a hydrogen atom or -(L)n-GP, in which n is equal to 0 or 1, L is a linker arm, and GP is a hydrosolubilizing group; as well as their physiologically acceptable salts, solvates, or hydrates. The invention also provides intermediates for the synthesis thereof and detection methods employing them. The invention provides probes with formula (I): in which: X1═NH, O, or S; X2═O or S; SE is a labile group, which may be eliminated under the action of a stimulus that may in particular be the presence of an enzyme, a chemical ...more ...less
10
US10215740B2
Publication/Patent Number: US10215740B2
Publication date: 2019-02-26
Application number: 14/908,935
Filing date: 2014-07-28
Abstract: The present invention relates to a method for manufacturing a chromatography column, in particular for a gas phase chromatography, comprising a stationary phase made from a sol. This method comprises the following steps: (a) introducing this sol at the first end of the column, (b) moving said sol towards the second end of the column, so that a sol layer is formed on the internal wall of the column, this layer being able to form a gel on said internal wall, and (c) drying of the gel. The present invention also relates to a capillary column as well as to a microcolumn which may be manufactured according to this method. The present invention relates to a method for manufacturing a chromatography column, in particular for a gas phase chromatography, comprising a stationary phase made from a sol. This method comprises the following steps: (a) introducing this sol at the ...more ...less
11
US10189970B2
Publication/Patent Number: US10189970B2
Publication date: 2019-01-29
Application number: 14/438,137
Filing date: 2013-10-23
Abstract: A granulation method that can be used to obtain a polymer from “post-consumer” materials, and a motor vehicle part made from polymers produced by recycling used polymers.
12
US20190002836A1
Publication/Patent Number: US20190002836A1
Publication date: 2019-01-03
Application number: 16/064,322
Filing date: 2016-12-29
Abstract: The invention relates to a method for manufacturing a bio-ink by additive deposition, which comprises supplying: a first solution including between 5 and 40 wt. % gelatin; a second solution including between 15 and 35 .wt. % alginate; a third solution including between 1 and 15 wt. % fibrinogen, and optionally living cells in suspension; and creating a mixture including: around 35 to 65 vol. % of the first solution; around 15 to 35 vol. % of the second solution; and around 15 to 35 vol. % of the third solution, said proportions being selected so that they add up to 100%. Said bio-ink allows the additive deposition of objects that can be polymerised by means of a solution including calcium ions and thrombin. Said objects can be incubated and can be used as a substitute for body tissue, for example (with added fibroblasts) as skin substitute. The invention relates to a method for manufacturing a bio-ink by additive deposition, which comprises supplying: a first solution including between 5 and 40 wt. % gelatin; a second solution including between 15 and 35 .wt. % alginate; a third solution including between 1 and 15 ...more ...less
14
US20190055288A1
Publication/Patent Number: US20190055288A1
Publication date: 2019-02-21
Application number: 15/769,534
Filing date: 2016-10-20
Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.
15
EP3461846A1
Publication/Patent Number: EP3461846A1
Publication date: 2019-04-03
Application number: 18203745.7
Filing date: 2012-03-29
Abstract: The present invention provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNy production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg. The present invention also relates to uses of said antibodies for treating autoimmune diseases, transplantation rejection and graft versus host disease." The present invention provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNy production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg. The present invention also relates ...more ...less
17
US10180437B2
Publication/Patent Number: US10180437B2
Publication date: 2019-01-15
Application number: 15/119,664
Filing date: 2015-02-16
Abstract: A method for predicting cellular, tissue and clinical radiosensitivity, which is based on the determination and correlation of multiple parameters and cellular and enzymatic criteria.