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1
US10920222B2
Treating and preventing microbial infections
Publication/Patent Number: US10920222B2 Publication Date: 2021-02-16 Application Number: 16/700,856 Filing Date: 2019-12-02 Inventor: Sommer, Morten   Martinez, Virginia   Van, Der Helm Eric   Haaber, Jakob Krause   De, Santiago Torio Ana   Grøndahl, Christian   Clube, Jasper   Assignee: SNIPR Biome ApS   IPC: A61K39/00 Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.
2
US2021054372A1
METHODS OF INACTIVATING GENE EDITING MACHINERIES
Publication/Patent Number: US2021054372A1 Publication Date: 2021-02-25 Application Number: 17/074,021 Filing Date: 2020-10-19 Inventor: Tsang, Stephen H.   Wu, Wen-hsuan   Tsai, Yi-ting   Assignee: The Trustees of Columbia University in the City of New York   IPC: C12N15/11 Abstract: The present disclosure provides for systems and methods to limit the duration of a gene editing machinery, such as an endonuclease system. A self-terminating mechanism may be introduced by placing one or more target sequences (targeted by the gene editing machinery) on a polynucleotide encoding at least one component of the gene editing machinery/system.
3
US2021139892A1
COMPOSITIONS AND METHODS FOR DELIVERY OF RNA TO A CELL
Publication/Patent Number: US2021139892A1 Publication Date: 2021-05-13 Application Number: 17/253,536 Filing Date: 2019-07-02 Inventor: Wilson, Ross Crawford   Mcgourty, Colleen Amanda   De, Oñate Monje Lorena   Assignee: The Regents of the University of California   IPC: C12N15/11 Abstract: The present disclosure provides a system comprising: a) a modified RNA-binding protein (RBP) comprising: i) an RBP; and ii) one or more endosomolytic peptides (ELPs) covalently linked, directly or via a linker, to the RBP; and b) a modified cargo RNA complexed to the RBP, wherein the modified cargo RNA comprises a cargo RNA modified to include one or more RBP binding sites that are bound by the RBP present in the modified RBP. The present disclosure also provides a method of delivering a cargo RNA to a eukaryotic cell, the method comprising contacting the cell with the system of the present disclosure. The present disclosure provides methods of delivering a cargo RNA to the cytoplasm of a cell. The present disclosure provides methods of delivering a cargo RNA to the cytosol of a cell.
4
US2021139891A1
MODIFIED GUIDE RNAS, CRISPR-RIBONUCLEOTPROTEIN COMPLEXES AND METHODS OF USE
Publication/Patent Number: US2021139891A1 Publication Date: 2021-05-13 Application Number: 17/121,187 Filing Date: 2020-12-14 Inventor: Carlson-stevermer, Jared Matthew   Saha, Krishanu   Abdeen, Amr Ashraf   Kohlenberg, Lucille Katherine   Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION   IPC: C12N15/11 Abstract: Described herein are modified guide RNAs such as a single guide RNA including, from 5′ to 3′, a single-stranded protospacer sequence, a first complementary strand of a binding region for the Cas9 polypeptide, an aptamer that binds a biotin-binding molecule, and a second complementary strand of the binding region for the Cas9 polypeptide. Also described is an RNP complex including the modified guide RNA and a Cas9 polypeptide or active fragment thereof. Also included are methods of modifying target genes in cells using the modified guide RNAs.
5
US11085043B2
Euglobulin-based method for determining the biological activity of defibrotide
Publication/Patent Number: US11085043B2 Publication Date: 2021-08-10 Application Number: 16/816,741 Filing Date: 2020-03-12 Inventor: Ignoni, Terenzio   Kumar, Vijay   Islam, Khalid   Assignee: GENTIUM S.R.L.   IPC: C12N15/11 Abstract: It is disclosed a method for determining the biological activity of defibrotide, which comprises the steps of: a) bringing into contact defibrotide, mammalian euglobulin and a substrate specific for the plasmin which, by reaction with the plasmin, provides a measurable product; and b) measuring the amount of product formed at successive times, to thereby determine the biological activity of the defibrotide. Liquid defibrotide formulations are also disclosed, preferably water solutions, having a defined biological activity and, in particular, having an activity of 25 to 35 IU/mg of defibrotide, preferably from 27 to 32 IU/mg and, more preferably, from 28 to 32 IU/mg.
6
US2021123046A1
OPTIMIZED SMALL GUIDE RNAS AND METHODS OF USE
Publication/Patent Number: US2021123046A1 Publication Date: 2021-04-29 Application Number: 17/033,255 Filing Date: 2020-09-25 Inventor: Huang, Bo   Chen, Baohui   Qi, Lei   Gilbert, Luke   Assignee: The Regents of the University of California   IPC: C12N15/11 Abstract: Methods, compositions, and kits are provided herein for CRISPER/Cas-mediated nucleic acid detection or modification.
7
US2021214723A1
MATERIALS AND METHODS FOR TREATING CANCER
Publication/Patent Number: US2021214723A1 Publication Date: 2021-07-15 Application Number: 15/733,836 Filing Date: 2019-05-31 Inventor: Kenderian, Saad J.   Sterner, Rosalie M.   Cox, Michelle J.   Sakemura, Reona   Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH   IPC: C12N15/11 Abstract: This document provides methods and materials involved in treating cancer. For example, chimeric antigen receptor T cells having reduced levels of GM-CSF are provided. Also provided as methods for making and using chimeric antigen receptor T cells having reduced levels of GM-CSF.
8
US10907150B2
Modified guide RNAs, CRISPR-ribonucleotprotein complexes and methods of use
Publication/Patent Number: US10907150B2 Publication Date: 2021-02-02 Application Number: 16/008,376 Filing Date: 2018-06-14 Inventor: Carlson-stevermer, Jared Matthew   Saha, Krishanu   Abdeen, Amr Ashraf   Kohlenberg, Lucille Katherine   Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION   IPC: C12N15/11 Abstract: Described herein are modified guide RNAs such as a single guide RNA including, from 5′ to 3′, a single-stranded protospacer sequence, a first complementary strand of a binding region for the Cas9 polypeptide, an aptamer that binds a biotin-binding molecule, and a second complementary strand of the binding region for the Cas9 polypeptide. Also described is an RNP complex including the modified guide RNA and a Cas9 polypeptide or active fragment thereof. Also included are methods of modifying target genes in cells using the modified guide RNAs.
9
US2021102199A1
FRAGMENT SIZE CHARACTERIZATION OF CELL-FREE DNA MUTATIONS FROM CLONAL HEMATOPOIESIS
Publication/Patent Number: US2021102199A1 Publication Date: 2021-04-08 Application Number: 17/022,597 Filing Date: 2020-09-16 Inventor: Jiang, Tingting   Assignee: ILLUMINA, INC.   IPC: C12N15/11 Abstract: Methods and systems are provided for differentiating between cancer variants and somatic variants originating from hematopoietic cells in a cell free DNA sample. In some embodiments, the cancer variants can be distinguished from a somatic variants originating from hematopoietic cells based on fragment size distribution.
10
US2021163928A1
MESSENGER RNA COMPRISING FUNCTIONAL RNA ELEMENTS
Publication/Patent Number: US2021163928A1 Publication Date: 2021-06-03 Application Number: 17/041,332 Filing Date: 2019-04-11 Inventor: Reid, David   KÖhrer, Caroline   Jain, Ruchi   Moore, Melissa J.   Donovan, Scott   Larsen, Aaron   Presnyak, Vladimir   Assignee: ModernaTX, Inc.   IPC: C12N15/11 Abstract: The present disclosure provides messenger RNAs (mRNAs) having chemical and/or structural modifications, including RNA elements and/or modified nucleotides, in particular C-rich or CG-rich elements, which provide a desired translational regulatory activity to the mRNA.
11
US2021198665A1
TREATING AND PREVENTING MICROBIAL INFECTIONS
Publication/Patent Number: US2021198665A1 Publication Date: 2021-07-01 Application Number: 17/199,106 Filing Date: 2021-03-11 Inventor: Sommer, Morten   Martinez, Virginia   Van, Der Helm Eric   Haaber, Jakob Krause   De, Santiago Torio Ana   GrØndahl, Christian   Clube, Jasper   Assignee: SNIPR Biome ApS   IPC: C12N15/11 Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.
12
US2021171943A1
COMPOSITIONS AND METHODS FOR TREATING DISORDERS OF GENOMIC IMPRINTING
Publication/Patent Number: US2021171943A1 Publication Date: 2021-06-10 Application Number: 16/770,877 Filing Date: 2018-12-07 Inventor: Chamberlain, Stormy   Cotney, Justin   Langouët, Maéva   Lalande, Marc   Assignee: University of Connecticut   IPC: C12N15/11 Abstract: Disclosed herein are compositions, kits, and methods for treating a disorder of genomic imprinting in a subject. The method may include modifying a zinc-finger protein 274 (ZNF274) binding site on maternal chromosome 15 at position 15q11-q13 of the subject, such that the binding of a ZNF274 protein to the ZNF274 binding site is reduced relative to a control. The ZNF274 binding site comprises a polynucleotide having at least 90% sequence identify to SEQ ID NO: 1 or SEQ ID NO: 42. Further provided are DNA targeting systems that bind to a ZNF274 binding site or to a gene encoding a ZNF274 protein.
13
US11046954B2
Targeted protein degradation to attenuate adoptive T-cell therapy associated adverse inflammatory responses
Publication/Patent Number: US11046954B2 Publication Date: 2021-06-29 Application Number: 15/889,963 Filing Date: 2018-02-06 Inventor: Bradner, James   Roberts, Justin   Nabet, Behnam   Winter, Georg   Phillips, Andrew J.   Heffernan, Timothy   Buckley, Dennis   Assignee: DANA-FARBER CANCER INSTITUTE, INC.   IPC: A61K35/17 Abstract: This invention is in the area of compositions and methods for regulating chimeric antigen receptor immune effector cell, for example T-cell (CAR-T), therapy to modulate associated adverse inflammatory responses, for example, cytokine release syndrome and tumor lysis syndrome, using targeted protein degradation.