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1
US10278373B2
Publication/Patent Number: US10278373B2
Publication date: 2019-05-07
Application number: 15/029,305
Filing date: 2014-10-17
Abstract: This invention provides an HLA class I-expressing non-human animal that can be prepared efficiently in a simple manner within a short period of time, in which the transgene copy number to be introduced thereinto and the integration site of transgene are regulated, and in which the expression level of the transgene and the site of expression thereof are regulated. The invention also provides a method for preparing such non-human animal. In such HLA class I gene knock-in non-human animal, an artificial chimeric gene encoding an artificial chimeric protein comprising a protein composed of β2 microglobulin, HLA class I α1 and α2 regions, and an MHC class I α3 region of a non-human animal ligated in such order from the N terminus is expressed under the control of a transcription regulatory region of β2 microglobulin gene of the non-human animal. This invention provides an HLA class I-expressing non-human animal that can be prepared efficiently in a simple manner within a short period of time, in which the transgene copy number to be introduced thereinto and the integration site of transgene are regulated, and in which ...more ...less
2
HK1223507A1
Publication/Patent Number: HK1223507A1
Publication date: 2017-08-04
Application number: 16112002
Filing date: 2016-10-18
IPC: A01K
3
EP3058819A4
Publication/Patent Number: EP3058819A4
Publication date: 2017-05-17
Application number: 14853234
Filing date: 2014-10-17
Abstract: This invention provides an HLA class I-expressing non-human animal that can be prepared efficiently in a simple manner within a short period of time
4
US20160227750A1
Publication/Patent Number: US20160227750A1
Publication date: 2016-08-11
Application number: 15/029,305
Filing date: 2014-10-17
Abstract: This invention provides an HLA class I-expressing non-human animal that can be prepared efficiently in a simple manner within a short period of time, in which the transgene copy number to be introduced thereinto and the integration site of transgene are regulated, and in which the expression level of the transgene and the site of expression thereof are regulated. The invention also provides a method for preparing such non-human animal. In such HLA class I gene knock-in non-human animal, an artificial chimeric gene encoding an artificial chimeric protein comprising a protein composed of β2 microglobulin, HLA class I α1 and α2 regions, and an MHC class I α3 region of a non-human animal ligated in such order from the N terminus is expressed under the control of a transcription regulatory region of β2 microglobulin gene of the non-human animal. This invention provides an HLA class I-expressing non-human animal that can be prepared efficiently in a simple manner within a short period of time, in which the transgene copy number to be introduced thereinto and the integration site of transgene are regulated, and in which ...more ...less
5
CN105578876A
Publication/Patent Number: CN105578876A
Publication date: 2016-05-11
Application number: 201480053640
Filing date: 2014-10-17
Abstract: Provided are an HLA class I expressing non-human animal that can be efficiently and simply produced in a short time
6
EP3058819A1
Publication/Patent Number: EP3058819A1
Publication date: 2016-08-24
Application number: 14853234.4
Filing date: 2014-10-17
Abstract: This invention provides an HLA class I-expressing non-human animal that can be prepared efficiently in a simple manner within a short period of time, in which the transgene copy number to be introduced thereinto and the integration site of transgene are regulated, and in which the expression level of the transgene and the site of expression thereof are regulated. The invention also provides a method for preparing such non-human animal. In such HLA class I gene knock-in non-human animal, an artificial chimeric gene encoding an artificial chimeric protein comprising a protein composed of β2 microglobulin, HLA class I α1 and α2 regions, and an MHC class I α3 region of a non-human animal ligated in such order from the N terminus is expressed under the control of a transcription regulatory region of β2 microglobulin gene of the non-human animal. This invention provides an HLA class I-expressing non-human animal that can be prepared efficiently in a simple manner within a short period of time, in which the transgene copy number to be introduced thereinto and the integration site of transgene are regulated, and in which ...more ...less
7
WO2015056774A1
Publication/Patent Number: WO2015056774A1
Publication date: 2015-04-23
Application number: 2014077668
Filing date: 2014-10-17
Abstract:  Provided are an HLA class I expressing non-human animal that can be efficiently and simply produced in a short time
8
US8232447B2
Publication/Patent Number: US8232447B2
Publication date: 2012-07-31
Application number: 12/525,410
Filing date: 2007-11-30
Assignee: MSD K.K.
Abstract: It is an object to provide a gene-modified non-human animal having inactivated MGAT2 gene and a gene-modified non-human animal cell, which are useful for the search of the function of MGAT2 in vivo. It is another object to provide a method for screening of a compound capable of inhibiting the activity of MGAT2 and a compound capable of inhibiting the activity of MGAT2. It is further another object to provide a method for detecting a disease induced by abnormal lipid metabolism based on the expression level or activity of MGAT2. A method for screening of a compound by using a gene-modified non-human mammal having the artificially inhibited expression of MGAT2 gene and a cell thereof enable to prevent or treat a disease induced by abnormal lipid metabolism. Also a screening of a compound capable of inhibiting or enhancing the function of MGAT2 enables to prevent or treat a disease induced by abnormal lipid metabolism. It is an object to provide a gene-modified non-human animal having inactivated MGAT2 gene and a gene-modified non-human animal cell, which are useful for the search of the function of MGAT2 in vivo. It is another object to provide a method for screening of a compound capable of ...more ...less
9
US20100074888A1
Publication/Patent Number: US20100074888A1
Publication date: 2010-03-25
Application number: 12/525,410
Filing date: 2007-11-30
Abstract: It is an object to provide a gene-modified non-human animal having inactivated MGAT2 gene and a gene-modified non-human animal cell, which are useful for the search of the function of MGAT2 in vivo. It is another object to provide a method for screening of a compound capable of inhibiting the activity of MGAT2 and a compound capable of inhibiting the activity of MGAT2. It is further another object to provide a method for detecting a disease induced by abnormal lipid metabolism based on the expression level or activity of MGAT2. A method for screening of a compound by using a gene-modified non-human mammal having the artificially inhibited expression of MGAT2 gene and a cell thereof enable to prevent or treat a disease induced by abnormal lipid metabolism. Also a screening of a compound capable of inhibiting or enhancing the function of MGAT2 enables to prevent or treat a disease induced by abnormal lipid metabolism. It is an object to provide a gene-modified non-human animal having inactivated MGAT2 gene and a gene-modified non-human animal cell, which are useful for the search of the function of MGAT2 in vivo. It is another object to provide a method for screening of a compound capable of ...more ...less
11
JP2003205520A
Publication/Patent Number: JP2003205520A
Publication date: 2003-07-22
Application number: 2002005696
Filing date: 2002-01-15
Abstract: PROBLEM TO BE SOLVED: To obtain a non-chlorine type barrier film for food packaging material low in oxygen permeability and humidity permeability
12
JPH0288282A
Publication/Patent Number: JPH0288282A
Publication date: 1990-03-28
Application number: 23886788
Filing date: 1988-09-26
Abstract: PURPOSE:To obtain a low-cost slip perforation printer imparting an identification stamp specified by customer by a method wherein an operation part movably holding pins is pressed down against the force of a pressing member which presses the operation part in a retracting direction PURPOSE:To obtain a low-cost slip perforation printer imparting an identification stamp specified by customer by a method wherein an operation part movably holding pins is pressed down against the force of a pressing member which presses the operation part in a retracting ...more ...less