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1
US20190055232A1
Publication/Patent Number: US20190055232A1
Publication date: 2019-02-21
Application number: 16/070,936
Filing date: 2017-02-16
Abstract: The present invention relates to novel compounds of formula (I) and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and in the treatment of cancer. The present invention relates to novel compounds of formula (I) and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 ...more ...less
2
US20190010122A1
Publication/Patent Number: US20190010122A1
Publication date: 2019-01-10
Application number: 16/080,506
Filing date: 2017-03-17
Abstract: The invention relates to novel compounds of formula I which are inhibitors of deubiquitylating enzymes (DUBs) and/or desumoylating enzymes. In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 7 or ubiquitin specific peptidase 7 (USP7). The invention further relates to methods for the preparation of these compounds and to their use in the treatment of cancer. The invention relates to novel compounds of formula I which are inhibitors of deubiquitylating enzymes (DUBs) and/or desumoylating enzymes. In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 7 or ubiquitin specific peptidase 7 (USP7). The ...more ...less
4
US20180162852A1
Publication/Patent Number: US20180162852A1
Publication date: 2018-06-14
Application number: 15/894,025
Filing date: 2018-02-12
Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein. The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB ...more ...less
5
US9926307B2
Publication/Patent Number: US9926307B2
Publication date: 2018-03-27
Application number: 15/513,125
Filing date: 2015-09-22
Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein. The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB ...more ...less
6
EP3416960A1
Publication/Patent Number: EP3416960A1
Publication date: 2018-12-26
Application number: 17706864.0
Filing date: 2017-02-16
7
US20170247365A1
Publication/Patent Number: US20170247365A1
Publication date: 2017-08-31
Application number: 15/513,125
Filing date: 2015-09-22
Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein. The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB ...more ...less
8
AU2015323572A1
Publication/Patent Number: AU2015323572A1
Publication date: 2017-03-23
Application number: 2015323572
Filing date: 2015-09-22
Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular
9
SG11201700847YA
Publication/Patent Number: SG11201700847YA
Publication date: 2017-04-27
Application number: 11201700847Y
Filing date: 2015-09-22
10
CN107001339A
Publication/Patent Number: CN107001339A
Publication date: 2017-08-01
Application number: 201580051365
Filing date: 2015-09-22
Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular
11
MX2017003358A
Publication/Patent Number: MX2017003358A
Publication date: 2017-09-13
Application number: 2017003358
Filing date: 2015-09-22
Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular
12
EP3197883A1
Publication/Patent Number: EP3197883A1
Publication date: 2017-08-02
Application number: 15774652.0
Filing date: 2015-09-22
13
BR112017005887A2
Publication/Patent Number: BR112017005887A2
Publication date: 2017-12-12
Application number: 112017005887
Filing date: 2015-09-22
Abstract: resumo ?novos compostos? a presente invenção refere-se a novos compostos e métodos para a produção de inibidores de enzimas deubiquilantes (dubs). em particular, a invenção refere-se à inibição da hidrolase c-terminal l1 de ubiquitina (uchl1). a invenção refere-se ainda à utilização de inibidores de dub no tratamento do câncer e outras indicações. os compostos da invenção incluem os compostos com a fórmula (i) (i) ou um sal farmaceuticamente aceitável dos mesmos, em que r1 a r8 são conforme aqui definidos. resumo ?novos compostos? a presente invenção refere-se a novos compostos e métodos para a produção de inibidores de enzimas deubiquilantes (dubs). em particular, a invenção refere-se à inibição da hidrolase c-terminal l1 de ubiquitina (uchl1). a invenção refere-se ainda à uti ...more ...less
14
KR20170055499A
Publication/Patent Number: KR20170055499A
Publication date: 2017-05-19
Application number: 20177009125
Filing date: 2015-09-22
Abstract: 본 발명은 신규한 화합물 및 탈 유도체화 효소(deubiquitylating
15
WO2017158388A1
Publication/Patent Number: WO2017158388A1
Publication date: 2017-09-21
Application number: 2017050763
Filing date: 2017-03-17
Abstract: The invention relates to novel compounds of formula I which are inhibitors of deubiquitylating enzymes (DUBs) and/or desumoylating enzymes. In particular
16
WO2017141036A1
Publication/Patent Number: WO2017141036A1
Publication date: 2017-08-24
Application number: 2017050403
Filing date: 2017-02-16
Abstract: The present invention relates to novel compounds of formula (I) and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular
17
GB2537363A
Publication/Patent Number: GB2537363A
Publication date: 2016-10-19
Application number: 201506166
Filing date: 2015-04-12
Inventor: Ian, Karl Jones  
Abstract: A coil guard 20 has one part 32 to engage a radially outward facing surface 18 of an annular coil 10 and another part 22 to engage a radially inward facing surface 16 of the annular coil 10. Ideally both parts also engage the axially facing surface of the coil. The parts can be releasably fastened together by cooperating hook and loop pads 29 A coil guard 20 has one part 32 to engage a radially outward facing surface 18 of an annular coil 10 and another part 22 to engage a radially inward facing surface 16 of the annular coil 10. Ideally both parts also engage the axially facing surface of the coil. The parts can be ...more ...less
18
CA2958262A1
Publication/Patent Number: CA2958262A1
Publication date: 2016-03-31
Application number: 2958262
Filing date: 2015-09-22
Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular
19
WO2016046530A1
Publication/Patent Number: WO2016046530A1
Publication date: 2016-03-31
Application number: 2015052729
Filing date: 2015-09-22
Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular
20
GB201506166D0
Publication/Patent Number: GB201506166D0
Publication date: 2015-05-27
Application number: 201506166
Filing date: 2015-04-12
Inventor: Ian, Karl Jones  
Abstract: A coil guard 20 has one part 32 to engage a radially outward facing surface 18 of an annular coil 10 and another part 22 to engage a radially inward facing surface 16 of the annular coil 10. Ideally both parts also engage the axially facing surface of the coil. The parts can be releasably fastened together by cooperating hook and loop pads 29 A coil guard 20 has one part 32 to engage a radially outward facing surface 18 of an annular coil 10 and another part 22 to engage a radially inward facing surface 16 of the annular coil 10. Ideally both parts also engage the axially facing surface of the coil. The parts can be ...more ...less