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1
US10172925B2
Publication/Patent Number: US10172925B2
Publication date: 2019-01-08
Application number: 15/003,959
Filing date: 2016-01-22
Inventor: Nishimura, Takashi  
Assignee: Tella, Inc.
Abstract: The object aims to provide: a novel tumor antigen; a novel therapeutic agent useful in a method for treating a malignant neoplasm by utilizing the tumor antigen; and a tumor antigen which can be used as the therapeutic agent. Thus, disclosed are: a novel tumor antigen which has an epitope capable of inducing a Th1 cell which is a CD4-positive T cell specific to Survivin; and use of the tumor antigen. Specifically disclosed is a polypeptide which comprises an amino acid sequence depicted in SEQ ID NO:17 or the like and has an activity to cause the production of a cytokine by a Th cell that is a cell specific to Survivin. The peptide can induce a Th cell that is specific to Survivin and can cause the production of a cytokine by the Sur/Th cell when the peptide is incubated together with an antigen-presenting cell and a CD4-positive T cell. The object aims to provide: a novel tumor antigen; a novel therapeutic agent useful in a method for treating a malignant neoplasm by utilizing the tumor antigen; and a tumor antigen which can be used as the therapeutic agent. Thus, disclosed are: a novel tumor antigen which has ...more ...less
2
US20190178668A1
Publication/Patent Number: US20190178668A1
Publication date: 2019-06-13
Application number: 16/209,383
Filing date: 2018-12-04
Abstract: All information providing device includes an acquisition unit configured to acquire radio wave information indicating a radio-wave receiving sensitivity on a route; and a processor configured to estimate, in consideration of the radio wave information, a decrease time during which a movable body moves on a first route where the radio-wave receiving sensitivity is decreased, and to store, prior to the decrease time, data in an amount that allows contents of the data to be continuously output at least during the decrease time. All information providing device includes an acquisition unit configured to acquire radio wave information indicating a radio-wave receiving sensitivity on a route; and a processor configured to estimate, in consideration of the radio wave information, a decrease time during ...more ...less
3
US20190002414A1
Publication/Patent Number: US20190002414A1
Publication date: 2019-01-03
Application number: 15/781,925
Filing date: 2016-12-06
Abstract: A problem of the present invention is to provide a new compound which has NK1 receptor antagonist activity, and thus is useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. A compound represented by the formula (I): wherein W represents a fluorine atom and the like, ring A represents a cycloalkyl and the like, X1 represents CH or N, R represents methyl and the like, Y represents 0 to 2, U1, U2 and U3 each independently represents a single bond and the like, or a pharmaceutically acceptable salt thereof. The compounds of the present invention or pharmaceutically acceptable salts thereof have an excellent NK1 receptor antagonist activity, and thus are also useful as an agent for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. A problem of the present invention is to provide a new compound which has NK1 receptor antagonist activity, and thus is useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. A compound represented by the formula (I): wherein W ...more ...less
4
US10253075B2
Publication/Patent Number: US10253075B2
Publication date: 2019-04-09
Application number: 15/121,525
Filing date: 2015-02-26
Assignee: TELLA, INC.
Abstract: [Problem] To provide a polypeptide which enables stimulation of numerous T cells of different derivation, and to induce strong immunological response against numerous types of cancers. [Solution] Provided is a fused polypeptide that includes a helper epitope derived from the WT1 protein, and a killer epitope derived from the WT1 protein, wherein the polypeptide includes a total of 3 to 6 of the helper epitopes and the killer epitopes per molecule of the fused polypeptide. [Problem] To provide a polypeptide which enables stimulation of numerous T cells of different derivation, and to induce strong immunological response against numerous types of cancers. [Solution] Provided is a fused polypeptide that includes a helper epitope derived from the ...more ...less
5
US10276775B2
Publication/Patent Number: US10276775B2
Publication date: 2019-04-30
Application number: 14/978,242
Filing date: 2015-12-22
Abstract: A vibration device that includes a vibration portion, a support portion connected to the vibration portion, a bending-vibrating portion connected to the support portion, and a frame-shaped base portion connected to the bending-vibration portion and disposed so as to surround the vibration portion. The base portion defines a slit that extends in a first direction crossing a second direction in which the support portion extends from the vibration portion, the slit defining first and second fixed ends of the bending-vibrating portion and which are continuous with the base portion. A length between a portion of the bending-vibrating portion connected to the support portion to one of the first and second fixed ends of the bending-vibrating portion is in a range of λ/8 to 3λ/8, where λ denotes a wavelength of a bending vibration corresponding to a frequency of a characteristic vibration of the vibration portion. A vibration device that includes a vibration portion, a support portion connected to the vibration portion, a bending-vibrating portion connected to the support portion, and a frame-shaped base portion connected to the bending-vibration portion and disposed so as to surround the ...more ...less
6
US10228647B2
Publication/Patent Number: US10228647B2
Publication date: 2019-03-12
Application number: 15/897,356
Filing date: 2018-02-15
Abstract: A toner detection unit is configured by an LED that irradiates light toward an intermediate transfer belt, first and second light receiving elements that respectively receive specular reflection light and diffused reflection light of light irradiated toward the intermediate transfer belt from the LED, a circuit board, and a housing. The LED and the light receiving elements are mounted in a line on the circuit board. The housing is configured to guide, to the first light receiving element, the specular reflection light from a first region within an irradiation region on which light is irradiated from the LED on the intermediate transfer belt, and to guide, to the second light receiving element, the diffused reflection light from a second region which is different from the first region within the irradiation region. A toner detection unit is configured by an LED that irradiates light toward an intermediate transfer belt, first and second light receiving elements that respectively receive specular reflection light and diffused reflection light of light irradiated toward the intermediate ...more ...less
7
EP3461598A3
Publication/Patent Number: EP3461598A3
Publication date: 2019-05-15
Application number: 18197596.2
Filing date: 2018-09-28
Abstract: A manipulation unit includes a body, a tool holder, and a manipulated portion. The body has a first end surface attachable to an attachment target. The tool holder is located on a second end surface of the body, and a tool is attachable to the tool holder. The manipulated portion is located on an outer circumferential surface of the body and includes a manipulated surface that is set deeper in the body than a surrounding portion of the manipulated portion surrounding the manipulated surface. A manipulation unit includes a body, a tool holder, and a manipulated portion. The body has a first end surface attachable to an attachment target. The tool holder is located on a second end surface of the body, and a tool is attachable to the tool holder. The manipulated ...more ...less
8
EP3476550A1
Publication/Patent Number: EP3476550A1
Publication date: 2019-05-01
Application number: 18196844.7
Filing date: 2018-09-26
Abstract: A robot system includes a robot, a detector, and a robot controller. The robot includes a plurality of motion axes. The detector is configured to detect an external force acting on the robot. The robot controller is configured to control a motion of the robot, and includes a motion controller. When the external force detected by the detector satisfies a first condition, the motion controller is configured to execute a backward withdrawal mode of causing the robot to withdraw by following, in a backward direction, a motion track that the robot followed. When an execution situation of the backward withdrawal mode satisfies a second condition, the motion controller is configured to execute an external-force reduction withdrawal mode of causing the robot to withdraw in a direction in which the external force reduces. A robot system includes a robot, a detector, and a robot controller. The robot includes a plurality of motion axes. The detector is configured to detect an external force acting on the robot. The robot controller is configured to control a motion of the robot, and includes a ...more ...less
9
US20190054715A1
Publication/Patent Number: US20190054715A1
Publication date: 2019-02-21
Application number: 16/078,404
Filing date: 2017-02-28
Abstract: The problem of the present invention is to offer a nonwoven fabric for reinforcing foam molded articles that enables cushion materials to be efficiently foam molded by improving adhesiveness of the reinforcing nonwoven fabric to a mold. The present invention is a nonwoven fabric for reinforcing foam molded articles, having a reinforcing nonwoven layer and at least one resin layer, wherein the reinforcing nonwoven layer and the at least one resin layer are laminated, the reinforcing nonwoven layer has a discontinuous part including a magnetic material, the at least one resin layer has a resin having softening point A of 20° C. or higher and 60° C. or lower, and the nonwoven fabric has an air permeability of 30 cc/cm2/sec or more and 300 cc/cm2/sec or less. The problem of the present invention is to offer a nonwoven fabric for reinforcing foam molded articles that enables cushion materials to be efficiently foam molded by improving adhesiveness of the reinforcing nonwoven fabric to a mold. The present invention is a nonwoven ...more ...less
10
EP2573910B1
Publication/Patent Number: EP2573910B1
Publication date: 2019-01-09
Application number: 11783558.7
Filing date: 2011-05-17
Abstract: A hybrid driving force transmission device includes a motor generator (9), a multi-plate dry clutch (7), a housing cover (60), a dust seal member (62), and a dust collection structure (63). The multi-plate dry clutch (7) is disposed at a position inner than the motor generator (9). The housing cover (60) is provided to cover the motor generator (9) and the multi-plate dry clutch (7), and divides the internal space into a clutch chamber (64) and a motor chamber (65). The dust seal member (62) is disposed at a position radially outside of a clutch chamber open surface (66) and seals between a rotor (92) and an inner wall (60a) of the housing cover (60). The dust collection structure (63) forms a dust collection space (69) in a region radially between the seal surface (68) formed by the dust seal member (62) and the clutch chamber open surface (66). A hybrid driving force transmission device includes a motor generator (9), a multi-plate dry clutch (7), a housing cover (60), a dust seal member (62), and a dust collection structure (63). The multi-plate dry clutch (7) is disposed at a position inner than the motor generator ...more ...less
11
US20190126476A1
Publication/Patent Number: US20190126476A1
Publication date: 2019-05-02
Application number: 16/160,977
Filing date: 2018-10-15
Abstract: A robot system includes a robot, a sensor, and a processor. The sensor is configured to detect an external force acting on the robot. The processor is configured to move the robot in a forward direction such that a representative point of the robot moves along a motion track in the forward direction; move the robot in a reverse direction such that the representative point moves along the motion track in the reverse direction opposite to the forward direction when the external force satisfies a first condition which includes a condition that the external force is larger than a first threshold force; and move the robot to reduce the external force when the external force satisfies a second condition which includes a condition that the external force is larger than a second threshold force even after the robot has been moved in the reverse direction. A robot system includes a robot, a sensor, and a processor. The sensor is configured to detect an external force acting on the robot. The processor is configured to move the robot in a forward direction such that a representative point of the robot moves along a motion track in ...more ...less
12
US20190099898A1
Publication/Patent Number: US20190099898A1
Publication date: 2019-04-04
Application number: 16/124,206
Filing date: 2018-09-07
Abstract: A manipulation unit includes a body, a tool holder, and a manipulated portion. The body has a first end, a second end opposite to the first end, and a peripheral surface connecting the first end and the second end. The first end is attachable to a robot arm. The tool holder is connected to the second end and configured to hold a tool. The manipulated portion is provided on the peripheral surface. The manipulated portion includes a manipulation surface and a surrounding portion. The robot arm is to be operated via the manipulation surface. The surrounding portion surrounds the manipulation surface such that the manipulation surface is recessed from the surrounding portion. A manipulation unit includes a body, a tool holder, and a manipulated portion. The body has a first end, a second end opposite to the first end, and a peripheral surface connecting the first end and the second end. The first end is attachable to a robot arm. The tool holder is ...more ...less
13
EP3461598A2
Publication/Patent Number: EP3461598A2
Publication date: 2019-04-03
Application number: 18197596.2
Filing date: 2018-09-28
Abstract: A manipulation unit includes a body, a tool holder, and a manipulated portion. The body has a first end surface attachable to an attachment target. The tool holder is located on a second end surface of the body, and a tool is attachable to the tool holder. The manipulated portion is located on an outer circumferential surface of the body and includes a manipulated surface that is set deeper in the body than a surrounding portion of the manipulated portion surrounding the manipulated surface. A manipulation unit includes a body, a tool holder, and a manipulated portion. The body has a first end surface attachable to an attachment target. The tool holder is located on a second end surface of the body, and a tool is attachable to the tool holder. The manipulated ...more ...less
15
US10276474B2
Publication/Patent Number: US10276474B2
Publication date: 2019-04-30
Application number: 15/091,957
Filing date: 2016-04-06
Abstract: A semiconductor device includes a plurality of semiconductor elements; insulating circuit boards each including an insulating substrate, a circuit portion on a front surface of the insulating substrate connected to one semiconductor element, and a metal portion on a rear surface of the insulating substrate; a metal plate joined to the metal portions of the plurality of insulating circuit boards; and a joint member joining the plurality of insulating circuit boards to the metal plate. The metal plate has a front surface in which the insulating circuit boards are arranged apart from each other, and a rear surface including first regions corresponding to positions of the metal portions and second regions other than the first regions. At least a part of a surface of each of the first regions has a surface work-hardened layer, and the second regions have a hardness different from that of the surface work-hardened layer. A semiconductor device includes a plurality of semiconductor elements; insulating circuit boards each including an insulating substrate, a circuit portion on a front surface of the insulating substrate connected to one semiconductor element, and a metal portion on a rear surface ...more ...less
16
EP3467133A1
Publication/Patent Number: EP3467133A1
Publication date: 2019-04-10
Application number: 17806731.0
Filing date: 2017-05-31
Abstract: A case hardening steel suitable as raw material for producing a mechanical structural part having high rotating bending fatigue strength and pitting fatigue strength at relatively low cost and a method of producing the case hardening steel are provided. A case hardening steel comprises a chemical composition containing, in mass%, C, Si, Mn, P, S, Cr, Mo, Al, N, and O in a predetermined relationship, with a balance being Fe and inevitable impurities, wherein √I ≤ 80 (where I denotes an area (µm2) of an oxide-based inclusion located in a fish eye central portion at a fracture surface after subjecting the case hardening steel to carburizing-quenching and tempering and then performing a rotating bending fatigue test). A case hardening steel suitable as raw material for producing a mechanical structural part having high rotating bending fatigue strength and pitting fatigue strength at relatively low cost and a method of producing the case hardening steel are provided. A case hardening steel ...more ...less
17
US10187540B2
Publication/Patent Number: US10187540B2
Publication date: 2019-01-22
Application number: 15/291,445
Filing date: 2016-10-12
Abstract: An image forming apparatus includes a light-receiving unit that includes light-receiving elements arranged along a movement direction of a target formed on an image carrier, and is arranged so as to receive light emitted from a light-emitting unit and specularly reflected off the image carrier; a member configured to limit a size, in the movement direction, of diffused reflection light that is incident on the light-receiving unit; a selection unit configured to select whether or not each of the light-receiving elements in the light-receiving unit is an effective light-receiving element; a generation unit configured to generate a detection signal from an output of the effective light-receiving element; and a detection unit configured to detect a target formed on the image carrier based on the detection signal. An image forming apparatus includes a light-receiving unit that includes light-receiving elements arranged along a movement direction of a target formed on an image carrier, and is arranged so as to receive light emitted from a light-emitting unit and specularly reflected off ...more ...less