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No. Publication Number Title Publication/Patent Number Publication/Patent Number Publication Date Publication Date
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1 UA86355U
METHOD FOR DETECTION OF MYCN AMPLIFICATION IN CHILDREN WITH NEUROBLASTOMA
Publication/Patent Number: UA86355U Publication Date: 2013-12-25 Application Number: 201308500 Filing Date: 2013-07-08 Inventor: Khranovska, Nataliia Mykolaivna   Klymniuk, Hryhorii Ivanovych   Pavlyk, Serhii Volodymyrovych   Skachkova, Oksana Volodymyrivna   Ionkina, Natalia Valeriivna   Shaida, Olena Viktorivna   Sverhun, Natalia Mykolaivna   Assignee: NATIONAL INSTITUTE OF CANCER   IPC: A61B10/00 Abstract: The method for the detection of MYCN amplification in the children with neuroblastoma comprises polymerase chain reaction with specific primers. The specific TaqMan probes of MGB type are used in real time mode. The presence of more than 10 copies of MYCN gene is indicative of non-favorable course of the disease. The method for the detection of MYCN amplification in the children with neuroblastoma comprises polymerase chain reaction with specific primers. The specific TaqMan probes of MGB type are used in real time mode. The presence of more than 10 copies of MYCN gene is indicative of ...More ...Less
2 UA68031U
METHOD OF COMBINED IMMUNOTHERAPY
Publication/Patent Number: UA68031U Publication Date: 2012-03-12 Application Number: 2011010719 Filing Date: 2011-09-06 Inventor: Khranovska, Nataliia Mykolaivna   Sitko, Valentyna Vitaliivna   Skachkova, Oksana Volodymyrivna   Sverhun, Natalia Mykolaivna   Assignee: NATIONAL INSTITUTE OF CANCER   IPC: A61K33/00 Abstract: A method of combined immunotherapy comprises the synergic use of DC-vaccinotherapy and low doses of cyclophosphamide administered intraperitoneally with strict delineation of its doses.
3 UA58444U
METHOD FOR DETERMINATION OF MUTATIONS IN GENE K-RAS IN PATIENTS WITH COLORECTAL CANCER
Publication/Patent Number: UA58444U Publication Date: 2011-04-11 Application Number: 2010011894 Filing Date: 2010-10-07 Inventor: Khranovska, Nataliia Mykolaivna   Sitko, Valentyna Vitaliivna   Skachkova, Oksana Volodymyrivna   Sverhun, Natalia Mykolaivna   Assignee: NATIONAL INSTITUTE OF CANCER   IPC: G01N33/00 Abstract: Method for determination of mutations in gene K-ras in patients with colorectal cancer includes separation of deoxyribonucleic acid from biological material and implementation of amplification of area under investigation by method of polymerase chain reaction. Determination of point mutations of gene is carried out in one step with use of specific primers and fluorescent probes with detection of results in mode of real time. Method for determination of mutations in gene K-ras in patients with colorectal cancer includes separation of deoxyribonucleic acid from biological material and implementation of amplification of area under investigation by method of polymerase chain reaction. Determination of ...More ...Less
4 UA57452U
METHOD FOR DETERMINATION OF MOLECULAR-GENETIC MARKER FOR PREDICTION OF COURSE OF DISEASE IN PATIENTS WITH HODGKIN LYMPHOMA
Publication/Patent Number: UA57452U Publication Date: 2011-02-25 Application Number: 2010010230 Filing Date: 2010-08-19 Inventor: Pozur, Volodymyr Kostiantynovych   Khranovska, Nataliia Mykolaivna   Kriachok, Iryna Anatoliivna   Tytorenko, Iryna Borysivna   Novosad, Olha Ihorivna   Sitko, Valentyna Vitaliivna   Skachkova, Oksana Volodymyrivna   Sverhun, Natalia Mykolaivna   Assignee: NATIONAL INSTITUTE OF CANCER   IPC: G01N33/49 Abstract: Method for determination of molecular-genetic marker for prediction of course of disease in patients with Hodgkin lymphoma includes separation of deoxyribonucleic acid from biological material and implementation of amplification of polymorphic region by method of polymerase chain reaction. Determination of polymorphic variant of gene is carried out in one step with use of fluorescent TaqMan-probes of MGB-type with detection of results in mode of real time. Method for determination of molecular-genetic marker for prediction of course of disease in patients with Hodgkin lymphoma includes separation of deoxyribonucleic acid from biological material and implementation of amplification of polymorphic region by method of polymerase ...More ...Less
5 UA49483U
METHOD FOR IMMUNOTHERAPY OF PATIENTS WITH LUNG CANCER
Publication/Patent Number: UA49483U Publication Date: 2010-04-26 Application Number: 2009012738 Filing Date: 2009-12-08 Inventor: Khranovska, Nataliia Mykolaivna   Orel, Valerii Emmanuilovych   Hanul, Andrii Valentynovych   Hanul, Valentyn Leonidovych   Sovenko, Volodymyr Mykhailovych   Skachkova, Oksana Volodymyrivna   Sytko, Valentyna Vitaliivna   Assignee: NATIONAL INSTITUTE OF CANCER   IPC: A61K35/14 Abstract: A method for immunotherapy of the patients with lung cancer comprises four courses of the intravenous vaccine based on the dendritic cells. On the sixth day of the culture
6 UA39714U
METHOD FOR EVALUATION OF SPECIFIC CELL RESPONSE BY MEANS OF REACTION OF RETARDATION OF MIGRATION OF LEUKOCYTES IN ONCOLOGICAL PATIENTS AFTER IMPLEMENTATION OF DENDRITOCELLULAR VACCINE THERAPY
Publication/Patent Number: UA39714U Publication Date: 2009-03-10 Application Number: 200811614 Filing Date: 2008-09-29 Inventor: Khranovska, Nataliia Mykolaivna   Sitko, Valentyna Vitaliivna   Skachkova, Oksana Volodymyrivna   Assignee: 'NATIONAL INSTITUTE OF CANCER' PUBLIC INSTITUTION   IPC: G01N33/50 Abstract: Method for evaluation of formation of specific cellular response in oncological patients after implementation of dendritocellular vaccine therapy includes determination of percentage of retardation of migration of leucocytes of peripheral blood by means of polyclonal activator of phytohemagliutin as positive control. Additionally one uses autolytic tumor antigene with which dendrite cells are loaded. At increase of percentage of retardation of migration of leucocytes compared to control values one determines presence of formation of specific cell response with prediction of positive response to vaccine therapy. Method for evaluation of formation of specific cellular response in oncological patients after implementation of dendritocellular vaccine therapy includes determination of percentage of retardation of migration of leucocytes of peripheral blood by means of polyclonal activator ...More ...Less
7 UA42622U
Method for control of specific cell response on tumor antigen in patients with malignant new growths
Publication/Patent Number: UA42622U Publication Date: 2009-07-10 Application Number: 200902055 Filing Date: 2009-03-10 Inventor: Shvets, Yuliia Viktorivna   Khranovska, Natalia Mykolaivna   Sitko, Valentyna Vitaliivna   Skachkova, Oksana Volodymyrivna   Assignee: 'NATIONAL INSTITUTE OF CANCER' PUBLIC INSTITUTION   IPC: G01N33/50 Abstract: Method for control of specific cell response on tumor antigen in patients with malignant new growths includes determination of cytokine profile of lymphocytes after sub-cultivation with tumor antigen. Investigations are carried out after each of four introductions of anti-tumor vaccine and at simultaneous reveal of decrease of secretion of interleukin -4 and increase of interferonin lymphocytes under effect of autologous tumor antigen one predicts positive response on anti-tumor vaccination carried out. Method for control of specific cell response on tumor antigen in patients with malignant new growths includes determination of cytokine profile of lymphocytes after sub-cultivation with tumor antigen. Investigations are carried out after each of four introductions of anti-tumor ...More ...Less
8 UA34590U
Method for evaluation of formation of specific immune response in oncological patients after course of dendrite-cellular vaccine therapy
Publication/Patent Number: UA34590U Publication Date: 2008-08-11 Application Number: 200805013 Filing Date: 2008-04-18 Inventor: Hrynevych, Yurii Yakymovych   Khranovska, Natalia Mykolaivna   Sitko, Valentyna Vitaliivna   Skachkova, Oksana Volodymyrivna   Assignee: 'NATIONAL CANCER INSTITUTE' PUBLIC INSTITUTION   IPC: G01N33/50 Abstract: Method for evaluation of formation of specific immune response in oncological patients after course of dendrite-cellular vaccine therapy includes determination of number of activated lymphocytes obtained from peripheral blood. One injects dendrite cells loaded with autological tumor cells to patient Method for evaluation of formation of specific immune response in oncological patients after course of dendrite-cellular vaccine therapy includes determination of number of activated lymphocytes obtained from peripheral blood. One injects dendrite cells loaded with autological ...More ...Less