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1 US2003219305A1
Manual disconnect apparatus and method
Publication/Patent Number: US2003219305A1 Publication Date: 2003-11-27 Application Number: 10/154,401 Filing Date: 2002-05-23 Inventor: Chen, Weixiong   Tate, Leon J.   Assignee: The Chamberlain Group, Inc.   IPC: B25G003/18 Abstract: A retrofitable manual disconnect apparatus includes an output shaft engagement member (20) that couples to the output shaft (13) of a powered movable barrier operator (12), a movable barrier engagement member (14) that couples to a movable barrier (11), and a hand-operable engagement mechanism (40) that controls coupling between the above components. In one embodiment, the hand-operable engagement mechanism (40) includes a pivoting handle (44) that cooperates with a biasing member (43) to control the position of a movable pin (41). In particular, the movable pin (41) can be controllable inserted in or removed from a hole (24) in the output shaft engagement member (20) to facilitate an engaged and disengaged state, respectively. A retrofitable manual disconnect apparatus includes an output shaft engagement member (20) that couples to the output shaft (13) of a powered movable barrier operator (12), a movable barrier engagement member (14) that couples to a movable barrier (11), and a hand-operable ...More Less
2 US2003219308A1
Barrier system
Publication/Patent Number: US2003219308A1 Publication Date: 2003-11-27 Application Number: 10/154,874 Filing Date: 2002-05-24 Inventor: Boulais, Keith E.   Becklin, Douglas   Bodimer, Gilbert Daniel   Avdek, Joseph Russel   Cicha, Jeffrey Allen   Jacobs, Richard Herman   Harrold, Brent Thomas   Mechache, Susan Renae   Assignee: Boulais, Keith E.   Becklin, Douglas   Bodimer, Gilbert Daniel   Avdek, Joseph Russel   Cicha, Jeffrey Allen   Jacobs, Richard Herman   Harrold, Brent Thomas   Mechache, Susan Renae   IPC: E01F013/00 Abstract: A barrier system is provided for absorbing the forces generated during collisions with vehicles. The system includes a plurality of interconnectable modular blocks that have a controlled rate of compression. The blocks connect with one another while allowing pivotable movement. In addition, an anchor system is provided that allows one or more blocks to be secured to the ground or to the floor, while still allowing the secured blocks some degree of pivotable movement. A barrier system is provided for absorbing the forces generated during collisions with vehicles. The system includes a plurality of interconnectable modular blocks that have a controlled rate of compression. The blocks connect with one another while allowing pivotable movement ...More Less
3 US2003219320A1
Throwaway insert
Publication/Patent Number: US2003219320A1 Publication Date: 2003-11-27 Application Number: 10/443,913 Filing Date: 2003-05-21 Inventor: Horiike, Nobukazu   Kitajima, Jun   Shimomura, Hiroshi   Ikenaga, Koichi   Assignee: Horiike, Nobukazu   Kitajima, Jun   Shimomura, Hiroshi   Ikenaga, Koichi   IPC: B23C005/00 Abstract: A throwaway insert enables reduction in cutting force and improves chip separation ability without sacrificing the strength of cutting edge thereof. An upper face of the throwaway insert is provided with an undulating portion, which is formed by alternately arranged concave portions and convex portions, so as to provide a wavy shape to the cutting edge. The undulating portion comprises four concave portions, i.e., a first deep-concave portion, a first shallow-concave portion, a second deep-concave portion, and a second shallow-concave portion. The first deep-concave portion and the second deep-concave portion are located so that effective cutting region of the cutting edge is divided into three portions having lengths substantially equal to each other, and the second deep-concave portion is made deeper than the first deep-concave portion. A throwaway insert enables reduction in cutting force and improves chip separation ability without sacrificing the strength of cutting edge thereof. An upper face of the throwaway insert is provided with an undulating portion, which is formed by alternately arranged concave ...More Less
4 US2003219332A1
Straddle loader
Publication/Patent Number: US2003219332A1 Publication Date: 2003-11-27 Application Number: 10/437,531 Filing Date: 2003-05-14 Inventor: Weis, Otto   Assignee: Noell Crane Systems GmbH   IPC: B60P003/00 Abstract: A straddle loader for lifting a load includes an upper frame having a spreader for grasping the load, a compartment for an operator, at least two traveling frames for receiving the load, and a lifting system connected to the upper frame and the plural traveling frames. The lifting system varies the distance between the upper frame and the plural traveling frames by uniformly transferring the load to the traveling frames so that the upper frame and the traveling frames remain parallel and perpendicular. The straddle loader further includes a plurality of telescoping beams associated with the lifting system so that at least two telescoping beams are connected to each of the traveling frames. Each telescoping beam is capable of extension and retraction. Stationary pivot shafts connect each end of each of the telescoping beams to the respective upper frame or traveling frame and to a pressure cylinder associated with each of the telescoping beams. The pressure cylinder is operatively mounted between one of the traveling frames a the respective one of the telescoping beams associated with the one frame and exerts a force on the respective telescoping beam simultaneous with extension of the telescoping beam. A straddle loader for lifting a load includes an upper frame having a spreader for grasping the load, a compartment for an operator, at least two traveling frames for receiving the load, and a lifting system connected to the upper frame and the plural traveling frames. The ...More Less
5 US2003219334A1
Method for highly efficient refuse removal from a construction site
Publication/Patent Number: US2003219334A1 Publication Date: 2003-11-27 Application Number: 10/357,079 Filing Date: 2003-02-03 Inventor: Caponey, Victor J.   Assignee: Caponey, Victor J.   IPC: B65F001/00 Abstract: A method, and system, for refuse removal from a collection site. The method comprises transporting multiple containers in an inverted stack to the collection site. Engaging a first container of the multiple containers with a rotating fork lift truck. Lifting the first container from the inverted stack with the rotating fork lift truck. Rotating the first container with the rotating fork lift truck. A method, and system, for refuse removal from a collection site. The method comprises transporting multiple containers in an inverted stack to the collection site. Engaging a first container of the multiple containers with a rotating fork lift truck. Lifting the first container ...More Less
6 US2003219336A1
Reversible volumetric machine
Publication/Patent Number: US2003219336A1 Publication Date: 2003-11-27 Application Number: 10/442,072 Filing Date: 2003-05-21 Inventor: Gonzaga, Tullio   Assignee: Gonzaga, Tullio   IPC: F03D007/00 Abstract: The invention relates to a fluid operated reversible volumetric machine comprising a receiving housing (C), at least two pairs of gear elements (I) mounted for rotation in the receiving housing (C) so that each gear element (I) is in meshing engagement with two adjoining gear elements (I) equal to it, an outer peripheral sequence, with respect to the gear elements, of suction openings or inlets (E alternating with as many delivery openings or outlet (U) formed in the receiving housing (C), an inner peripheral sequence, with respect to the gear elements, of delivery openings or outlets (U), alternating with as many suction openings or inlets (E) formed in the receiving housing (E), each outer and inner sequence comprising a number of inlets (E) or outlets (U) equal o the number of gear elements (I). The invention relates to a fluid operated reversible volumetric machine comprising a receiving housing (C), at least two pairs of gear elements (I) mounted for rotation in the receiving housing (C) so that each gear element (I) is in meshing engagement with two adjoining gear ...More Less
7 US2003219345A1
Lubricating device
Publication/Patent Number: US2003219345A1 Publication Date: 2003-11-27 Application Number: 10/464,638 Filing Date: 2003-06-19 Inventor: Sugita, Sumio   Nawamoto, Taikou   Sugiyama, Kenichi   Dairokuno, Satoshi   Okazaki, Yukiyoshi   Assignee: NSK LTD.   IPC: F04B039/04 Abstract: A rod body (30) is formed of magnetostrictive material and includes one end portion (30a) fixed, and a piston (35) is fixed to the other end portion (30b) of the rod body (30). The piston (35) is slidably disposed within a cylinder (36) in which there is formed a pump chamber (37). A suction port (39) for sucking lubricating oil into the pump chamber (37) is formed in the cylinder (36), while a suction valve (40) for preventing the lubricating oil from flowing out from the suction port (39) is disposed in the suction port (39). In the cylinder (36), there is disposed a nozzle (20) which communicates with the pump chamber (37) and has a sectional area smaller than the lubricating oil passage sectional area of the suction valve (40). There is disposed a coil (43) outside the rod body (30) and, to the coil (43), there is connected a control device (6) for controlling the supply of a current to be supplied to the coil (43). A rod body (30) is formed of magnetostrictive material and includes one end portion (30a) fixed, and a piston (35) is fixed to the other end portion (30b) of the rod body (30). The piston (35) is slidably disposed within a cylinder (36) in which there is formed a pump chamber ...More Less
8 US2003219359A1
Pipette tip
Publication/Patent Number: US2003219359A1 Publication Date: 2003-11-27 Application Number: 10/430,145 Filing Date: 2003-05-06 Inventor: Lenz, Jurgen   Molitor, Peter   Schicke, Michael   Assignee: Lenz, Jurgen   Molitor, Peter   Schicke, Michael   IPC: B01L003/02 Abstract: A pipette tip having an elongate, tubular body which has a pipetting aperture at one end and a placement aperture at the other end for placement on a receiving shank of a pipetting device, which is encompassed by an axially directed, inwardly inclined circumferential sealing lip which, at its base, is connected to the tubular body and can be elastically flared by placement on the receiving cone. A pipette tip having an elongate, tubular body which has a pipetting aperture at one end and a placement aperture at the other end for placement on a receiving shank of a pipetting device, which is encompassed by an axially directed, inwardly inclined circumferential sealing lip ...More Less
9 US2003219367A1
Process for the utilization of vanadium in chromium ore as ammonium metavanadate
Publication/Patent Number: US2003219367A1 Publication Date: 2003-11-27 Application Number: 10/404,194 Filing Date: 2003-04-01 Inventor: Weber, Rainer   Block, Hans-dieter   Batz, Michael   Assignee: Bayer Aktiengesellschaft   IPC: C22B034/22 Abstract: A process for recovering the vanadium present in the chromium ore chromite. as ammonium metavanadate, as a by-product of the fusion of the chromium ore with alkali and its work-up to produce sodium chromate solution and sodium dichromate.
10 US2003219377A1
Compounds and methods for diagnosing and treating amyloid-related conditions
Publication/Patent Number: US2003219377A1 Publication Date: 2003-11-27 Application Number: 10/421,126 Filing Date: 2003-04-23 Inventor: Raub, Thomas J.   Sawada, Geri A.   Tanis, Steven P.   Fici, Gregory J.   Buhl, Allen Edwin   Carter, Donald Bainbridge   Bandiera, Tiziano   Lansen, Jacqueline   Pellerano, Cesare   Savini, Luisa   Assignee: Pharmacia & Upjohn Company   IPC: A61K051/00 Abstract: The invention provides methods for diagnosing and treating amyloid-related conditions and compounds useful for the same. The invention provides for detecting, imaging, monitoring, diagnosing, and treating conditions characterized by the binding or aggregation of amyloid fibrils. More particularly, the invention relates to using quinolinehydrazone compounds for diagnosing and treating amyloidotic conditions and also as an antioxidant. The invention provides methods for diagnosing and treating amyloid-related conditions and compounds useful for the same. The invention provides for detecting, imaging, monitoring, diagnosing, and treating conditions characterized by the binding or aggregation of amyloid fibrils ...More Less
11 US2003219386A1
Intrapleural single-chain urokinase alone or complexed to its soluble receptor protects against pleural adhesions
Publication/Patent Number: US2003219386A1 Publication Date: 2003-11-27 Application Number: 10/407,821 Filing Date: 2003-04-04 Inventor: Idell, Steven   Assignee: Board of Regents, The University of Texas System   IPC: A61L009/04 Abstract: The present invention relates to methods of preventing or decreasing the severity of scarring in a subject comprising: obtaining a pharmaceutical composition comprising a single chain urokinase plasminogen activator molecule (scuPA) or a scuPA mimetic; and administering the pharmaceutical composition to a subject; wherein scarring in the subject is either prevented or decreased relative to an amount of scarring that would be expected if the pharmaceutical composition were not administered to the subject. The invention also relates to methods of screening for compounds that prevent or decrease the severity of scarring in a subject. The present invention relates to methods of preventing or decreasing the severity of scarring in a subject comprising: obtaining a pharmaceutical composition comprising a single chain urokinase plasminogen activator molecule (scuPA) or a scuPA mimetic; and administering the ...More Less
12 US2003219388A1
Remineralizing dental adhesive film
Publication/Patent Number: US2003219388A1 Publication Date: 2003-11-27 Application Number: 10/465,157 Filing Date: 2003-06-19 Inventor: Kropf, Christian   Wuelknitz, Peter   Assignee: Kropf, Christian   Wuelknitz, Peter   IPC: A61K007/28 Abstract: A dental adhesive film that, when applied to dental material, assists in the remineralization of dental material that exhibit damage from caries, lesions in the enamel and open dentine channels. The active compound in the dental adhesive film is a finely divided, poorly soluble calcium salt of phosphates, fluorides, fluorophosphates and mixtures thereof. Optionally present may be hydroxyl, carbonate or chloride ions. A dental adhesive film that, when applied to dental material, assists in the remineralization of dental material that exhibit damage from caries, lesions in the enamel and open dentine channels. The active compound in the dental adhesive film is a finely divided, poorly soluble ...More Less
13 US2003219389A1
Tooth whitening products
Publication/Patent Number: US2003219389A1 Publication Date: 2003-11-27 Application Number: 10/154,020 Filing Date: 2002-05-23 Inventor: Sagel, Paul Albert   Gerlach, Robert Woodrow   Assignee: The Procter & Gamble Company   IPC: A61K007/20 Abstract: A tooth whitening product is provided. The tooth whitening product includes a strip of material sized to cover the front surface of one or more teeth and soft tissue adjacent the front surface of the teeth. A thin layer of a tooth whitening composition is disposed on the strip of material. The whitening composition contains a peroxide active with a concentration greater than about 7.5% by weight of the tooth whitening composition, and the tooth whitening composition has a peroxide density less than about 1.3 mg/cm2. A tooth whitening product is provided. The tooth whitening product includes a strip of material sized to cover the front surface of one or more teeth and soft tissue adjacent the front surface of the teeth. A thin layer of a tooth whitening composition is disposed on the strip ...More Less
14 US2003219399A1
Hair conditioning compositions and their use in hair colouring compositions
Publication/Patent Number: US2003219399A1 Publication Date: 2003-11-27 Application Number: 10/460,068 Filing Date: 2003-06-12 Inventor: Hammond, Roger Clive   Geary, Nicholas William   Jones, Stevan David   Assignee: The Procter & Gamble Company   IPC: A61K007/06 Abstract: The present invention relates to a hair care composition comprising a aminofunctional polysiloxane having a specified average effective particle size which provides improved durable conditioning particularly when utilised in conjunction with a hair colouring composition.
15 US2003219400A1
Methods for treating or inhibiting neurotoxin-mediated syndromes
Publication/Patent Number: US2003219400A1 Publication Date: 2003-11-27 Application Number: 10/364,613 Filing Date: 2003-02-10 Inventor: Shoemaker, Ritchie   Hudnell, H. Kenneth   Assignee: Shoemaker, Ritchie   Hudnell, H. Kenneth   IPC: A61K038/23 Abstract: The present invention discloses methods of treating or inhibiting one or more of sick building syndrome (SBS), post-Lyme Disease Syndrome (PLDS), and chronic fatigue syndrome (CFS) by administering to a patient in need thereof an amount effective of cholestyramine and/or &agr;-melanocyte stimulating hormone to treat or inhibit one or more of these syndromes. The present invention discloses methods of treating or inhibiting one or more of sick building syndrome (SBS), post-Lyme Disease Syndrome (PLDS), and chronic fatigue syndrome (CFS) by administering to a patient in need thereof an amount effective of cholestyramine and/or ...More Less
16 US2003219404A1
Branched polyalkylene glycols
Publication/Patent Number: US2003219404A1 Publication Date: 2003-11-27 Application Number: 10/168,956 Filing Date: 2002-06-24 Inventor: Yamasaki, Motoo   Suzawa, Toshiyuki   Murakami, Tatsuya   Sakurai, Noriko   Yamashita, Kinya   Mukai, Mayumi   Kuwabara, Takashi   Ohta, So   Miki, Ichiro   Assignee: Yamasaki, Motoo   Suzawa, Toshiyuki   Murakami, Tatsuya   Sakurai, Noriko   Yamashita, Kinya   Mukai, Mayumi   Kuwabara, Takashi   Ohta, So   Miki, Ichiro   IPC: A61K038/21 Abstract: The present invention provides branched polyalkylene glycols useful as a chemically modifying agent for physiologically active polypeptides, wherein two single-chain polyalkylene glycols are linked to a group having a cyclic structure other than a plane structure, and wherein a group having reactivity with an amino acid side chain, an N-terminal amino group or a C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity is linked to the group having a structure other than a plane structure. The present invention provides branched polyalkylene glycols useful as a chemically modifying agent for physiologically active polypeptides, wherein two single-chain polyalkylene glycols are linked to a group having a cyclic structure other than a plane structure, and wherein a ...More Less
17 US2003219664A1
Electrophotographic photoreceptor, and electrophotographic apparatus using the same
Publication/Patent Number: US2003219664A1 Publication Date: 2003-11-27 Application Number: 10/357,491 Filing Date: 2003-02-04 Inventor: Ohkura, Kenichi   Ueno, Yoshihiro   Kuroda, Masami   Sekine, Nobuyuki   Assignee: Fuji Electric Imaging Device Co., Ltd.   IPC: G03G005/06 Abstract: An electrophotographic photoreceptor has excellent electrical properties and is stable even upon repeated use. An electrophotographic apparatus using the electrophotographic photoreceptor uses a compound having an excellent electron transporting ability in a photosensitive layer of the electrophotographic photoreceptor. An electrophotographic photoreceptor, in which a photosensitive layer is located on an electrically conductive substrate either directly or via an undercoat layer, contains a compound having a structure represented by the general formula (I). 1 An electrophotographic apparatus contains the above-mentioned electrophotographic photoreceptor, and carries out a charging process through a positive charging process. An electrophotographic photoreceptor has excellent electrical properties and is stable even upon repeated use. An electrophotographic apparatus using the electrophotographic photoreceptor uses a compound having an excellent electron transporting ability in a photosensitive layer ...More Less
18 US2003219680A1
Radiation-sensitive resin composition
Publication/Patent Number: US2003219680A1 Publication Date: 2003-11-27 Application Number: 10/428,139 Filing Date: 2003-05-02 Inventor: Nishimura, Yukio   Ishii, Hiroyuki   Nishimura, Isao   Kobayashi, Eiichi   Assignee: Nishimura, Yukio   Ishii, Hiroyuki   Nishimura, Isao   Kobayashi, Eiichi   IPC: G03F007/038 Abstract: A radiation-sensitive resin composition suitable as a chemically-amplified resist is provided. The composition comprised (A) a resin insoluble or scarcely soluble in alkali, but becoming alkali soluble by the action of an acid, and (B) a photoacid generator. The resin comprises a recurring unit of the following formula (I), 1 wherein R1 is typically a hydrogen atom and the —C (R5)3 structure is a 2-methyl-2-tricyclodecanyl group, 2-ethyl-2-tricyclodecanyl group, 2-methyl-2-adamantyl group, 2-ethyl-2-adamantyl group, 1-methylcyclopentyl group, 1-ethylcyclopentyl group, 1-methylcyclohexyl group, or 1-ethylcyclohexyl group. A radiation-sensitive resin composition suitable as a chemically-amplified resist is provided. The composition comprised (A) a resin insoluble or scarcely soluble in alkali, but becoming alkali soluble by the action of an acid, and (B) a photoacid generator. The resin comprises ...More Less
19 US2003219716A1
Method and apparatus for improving in vitro measurement of membrane permeability of chemical compounds
Publication/Patent Number: US2003219716A1 Publication Date: 2003-11-27 Application Number: 10/351,263 Filing Date: 2003-01-23 Inventor: Avdeef, Alex   Nielsen, Per E.   Du, Chau M.   Assignee: pION, INC.   IPC: C12Q001/00 Abstract: The invention described here improves the PAMPA (parallel artificial membrane permeability assay) high-throughput method used in lead compound selection and optimization in pharmaceutical and biotechnological research and development, and for identifying active compounds with the right plant distribution properties in agrochemical research and development. The invention described here is a robust method and apparatus for measurement of two physical properties, permeability and membrane retention of compounds, which overcomes several of the shortcomings in the prior art. This invention includes reagents specifically designed for enhancing the sensitivity of the assay, to allow a UV detection system to be used for concentration measurements, to accurately estimate and compensate for the effects of membrane retention and unstirred water layer, and to increase the speed of the assay. In this invention, concentrated phospholipid membrane barriers are used, consisting of 10-74% wt/vol commercially-available soybean lecithin extract dissolved in dodecane. Sample concentrations in both the donor and the acceptor compartments of the permeation cells are quickly measured by direct UV spectrophotometry. To reduce the excessive membrane retention of compounds by the concentrated phospholipid membrane barriers, an artificial sink state is created in the acceptor compartment of the permeation cells, by using surfactants, cyclodextrins, or water-soluble lipophilic polymers, which have low absorption of UV energy. A secondary sink state is created with ionizable molecules when the permeation cell contains a pH gradient between the donor and the acceptor solutions. The resultant “double-sink” condition forms a basis for successful modeling of the passive-diffusion transport of molecules in the human gastrointestinal tract (GIT). Also, this condition accelerates the transport of certain molecules across membranes, shortening the measurement time, and increasing the assay throughput. A new permeability equation is used, that takes into account (a) pH gradients between the two sides of the membrane barrier and (b) the retention of the molecules by the membrane, which the pH-gradient sink condition is unable to eliminate entirely. When combined with the prior art PAMPA practice of placing solubilizers, such as surfactants, bile salts, and water-soluble lipophilic polymers, into the donor compartment to overcome problems of low aqueous solubility of sample molecules, the said GIT model becomes modified to serve as a blood-brain barrier (BBB) absorption model. This invention can also improve performance in prior art PAMPA membrane barriers, and in several other types of membranes, such as, (i) nonporous synthetic membrane material (e.g., silicone rubber), (ii) dialysis membranes with a particular molecular weight cut-off, and (iii) monolayers of cultured cells (e.g., Caco-2, MDCK, or HT29) deposited onto the surface of porous microfilter supports. The invention described here improves the PAMPA (parallel artificial membrane permeability assay) high-throughput method used in lead compound selection and optimization in pharmaceutical and biotechnological research and development, and for identifying active compounds with ...More Less
20 US2003219724A1
Peptides which enhance transport across tissues and methods of identifying and using the same
Publication/Patent Number: US2003219724A1 Publication Date: 2003-11-27 Application Number: 10/329,130 Filing Date: 2002-12-23 Inventor: O'mahony, Daniel Joseph   Assignee: O'mahony, Daniel Joseph   IPC: C12Q001/70 Abstract: A method of identifying a peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or preselected phage library is plated unto or brought into contact with a first side, preferably the apical side, of a tissue sample or polarized tissue cell culture. At a predetermined time, the phage which is transported to a second side of the tissue opposite the first side, preferably the basolateral side, is harvested to select transported phage. This modified phage is amplified in a host. This cycle of events is repeated (using the transported phage produced in the most recent cycle) a predetermined number of times to obtain a selected phage library containing phage which can be transported from the first side to the second side. Lastly, the identity of at least one peptide coded by phage in the selected phage library is determined to identify a peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A method of identifying a peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or preselected phage library is plated unto or brought into contact with a first side ...More Less