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1
US20050277669A1
Publication/Patent Number: US20050277669A1
Publication date: 2005-12-15
Application number: 11/206,351
Filing date: 2005-08-17
Abstract: Disclosed are processes for preparing novel carbamate intermediates of paroxetine comprising dealkylating N-alkylparoxetine by reaction thereof with a haloalkyl ester of a haloformic acid, in a suitable organic solvent. Also disclosed are processes for preparing paroxetine comprising hydrolyzing the novel carbamate intermediates in a suitable solvent. Paroxetine prepared by the above processes can be neutralized with hydrogen chloride and crystallized as paroxetine hydrochloride anhydrous, hemihydrate or as a solvate of isopropanol. The invention is further directed to the novel carbamate intermediates formed by the disclosed processes. Disclosed are processes for preparing novel carbamate intermediates of paroxetine comprising dealkylating N-alkylparoxetine by reaction thereof with a haloalkyl ester of a haloformic acid, in a suitable organic solvent. Also disclosed are processes for preparing paroxetine ...more ...less
2
US20050277671A1
Publication/Patent Number: US20050277671A1
Publication date: 2005-12-15
Application number: 11/153,757
Filing date: 2005-06-14
Assignee: Pfizer Inc
Abstract: This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome. This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a ...more ...less
3
US20050277675A1
Publication/Patent Number: US20050277675A1
Publication date: 2005-12-15
Application number: 10/537,478
Filing date: 2003-12-02
Inventor: Fuugetsu, Bunshi
Abstract: A water solubilizer for nonocarbons contains a surfactant which can form a spherical micelle vesicle having a diameter of 50-2,000 nm in a water solution or a water-soluble polymer having a weight-average molecular weight of 10,000-50,000,000 as an active constituent. For example, the water solubilizer is used for purification of nonocarbons. A water solubilizer for nonocarbons contains a surfactant which can form a spherical micelle vesicle having a diameter of 50-2,000 nm in a water solution or a water-soluble polymer having a weight-average molecular weight of 10,000-50,000,000 as an active constituent. For ...more ...less
4
US20050277676A1
Publication/Patent Number: US20050277676A1
Publication date: 2005-12-15
Application number: 10/523,478
Filing date: 2003-08-06
Abstract: M3 Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
5
US20050277678A1
Publication/Patent Number: US20050277678A1
Publication date: 2005-12-15
Application number: 10/509,894
Filing date: 2003-04-01
Abstract: The present invention describes novel compounds having antiinflamatory activity, process for their preparation and pharmaceutical composition containing them.
6
US20050277684A1
Publication/Patent Number: US20050277684A1
Publication date: 2005-12-15
Application number: 11/097,972
Filing date: 2005-04-01
Inventor: Shen, Ben
Assignee: Shen, Ben
Abstract: The present invention relates to TG-25 and/or analogs thereof and their use of TG-25 in the treatment of cancer. TG-25 inhibits the growth of prostate cells by inhibiting DNA synthesis, more particularly by DNA cleavage.
7
US20050277692A1
Publication/Patent Number: US20050277692A1
Publication date: 2005-12-15
Application number: 11/127,403
Filing date: 2005-05-12
Abstract: The invention relates to a process for preparing difluorobenzo-1,3-dioxole-5-carboxylic acid and derivatives thereof, and to the use thereof for preparing medicaments and crop protection agents.
8
US20050277696A1
Publication/Patent Number: US20050277696A1
Publication date: 2005-12-15
Application number: 11/150,973
Filing date: 2005-06-13
Abstract: A method for treatment of age-related symptoms of epithelial tissues that includes the administration of an agent that disrupts F-actin polymerization in an amount effective to reduce rigidity in epithelial cells.
9
US20050277697A1
Publication/Patent Number: US20050277697A1
Publication date: 2005-12-15
Application number: 10/868,531
Filing date: 2004-06-15
Inventor: Wasson, Allan
Assignee: Wasson, Allan
Abstract: This invention relates to the treatment of a person exhibiting the effects of a flu-like or viral infection. The method includes treating the person with an amphetamine, amphetamine derivative, or a salt thereof in an amount effective to alleviate the adverse symptoms resulting from the flu-like or viral infection. This invention relates to the treatment of a person exhibiting the effects of a flu-like or viral infection. The method includes treating the person with an amphetamine, amphetamine derivative, or a salt thereof in an amount effective to alleviate the adverse symptoms resulting ...more ...less
10
US20050277699A1
Publication/Patent Number: US20050277699A1
Publication date: 2005-12-15
Application number: 11/147,966
Filing date: 2005-06-08
Abstract: Cosmetic compositions and methods of decreasing sebum production and/or pore size by contacting skin with a hair growth inhibitor, including polyamine derivatives and/or analogs; DFMO, N-acetyl cysteines; neutralized salts of a non-hydroxy C2-C40 dicarboxylic acids, preferably malonate salts; and mixtures thereof. Additional sebum and/or pore size reducing agents, such as carboxyalkylates of branched alcohols and/or ethoxylates thereof, cerulenin, triclosan, α-methylene-γ-butyrolactone, and EGCG, as well as mixtures thereof and analogs thereof, may be included in the inventive compositions and methods. Cosmetic compositions and methods of decreasing sebum production and/or pore size by contacting skin with a hair growth inhibitor, including polyamine derivatives and/or analogs; DFMO, N-acetyl cysteines; neutralized salts of a non-hydroxy C2-C40 dicarboxylic acids, preferably ...more ...less
11
US20050277705A1
Publication/Patent Number: US20050277705A1
Publication date: 2005-12-15
Application number: 11/125,133
Filing date: 2005-05-10
Abstract: Dental compositions are described which are photocurable by radiation with a wavelength greater than 390 nm. The compositions include a cationically active compound, a dental filler, optionally a dispersant, a cationic photoinitiator and a photosensitizer which is a thioxanthone salt substituted by at least one group containing an ammonium function. The composition has the advantage of remedying the color stability problems of finished dental products after crosslinking. Dental compositions are described which are photocurable by radiation with a wavelength greater than 390 nm. The compositions include a cationically active compound, a dental filler, optionally a dispersant, a cationic photoinitiator and a photosensitizer which is a thioxanthone ...more ...less
12
US20050277706A1
Publication/Patent Number: US20050277706A1
Publication date: 2005-12-15
Application number: 11/025,337
Filing date: 2004-12-29
Abstract: There is provided a highly functional one-step light-curing dental adhesive composition i) based on a multifunctional prepolymer mixture of 2,2-bis-[4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl]propane (“Bis-GMA”) and a multifunctional prepolymer formed by substitiuting hydrogen atoms of hydroxyl groups present in Bis-GMA molecules with methacrylate groups, in which the Bis-GMA is used as a base prepolymer of conventional dental adhesive compositions; and ii) comprising and acidic monomer for removing a portion of smear layer, which is allowed to be bonded without separate treatment of acid etchant, an adhesive monomer having both hydrophobic and hydrophilic properties, a hydrophilic monomer which is allowed to be bonded in the present of moisture, an inorganic filler for improving mechanical properties, diluent, water for demineralization, a photoinitiation system and other additives. There is provided a highly functional one-step light-curing dental adhesive composition i) based on a multifunctional prepolymer mixture of 2,2-bis-[4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl]propane (“Bis-GMA”) and a multifunctional prepolymer formed by ...more ...less
13
US20050277711A1
Publication/Patent Number: US20050277711A1
Publication date: 2005-12-15
Application number: 11/150,239
Filing date: 2005-06-13
Abstract: A coating composition comprising 100 pbw as solids of a synthetic resin emulsion and 1-300 pbw of a non-halogen flame retardant in which phosphorus and nitrogen-containing non-halogen flame retardant particles are surface coated with a functional group-containing organosilicon resin is applicable to vehicle interior materials such as car seats, floor mats and ceiling members. A coating composition comprising 100 pbw as solids of a synthetic resin emulsion and 1-300 pbw of a non-halogen flame retardant in which phosphorus and nitrogen-containing non-halogen flame retardant particles are surface coated with a functional group-containing organosilicon ...more ...less
14
US20050277725A1
Publication/Patent Number: US20050277725A1
Publication date: 2005-12-15
Application number: 11/151,255
Filing date: 2005-06-14
Abstract: An addition reaction-curable liquid silicone rubber composition includes an organopolysiloxane containing at least one Si-bonded vinyl group only at each end of its backbone and having a viscosity of from 1 to 1,000 Pa·s at 25° C., an organopolysiloxane containing at least two Si-bonded vinyl groups only in side chains on its backbone and having a viscosity of from 0.1 to 100 Pa·s at 25° C., the amount of siloxane units bonded to the vinyl groups being from 2 to 20 mole % of its total siloxane units, finely divided silica having a specific surface area of at least 50 m2/g, hexamethyldisilazane, water, an organohydrogenpolysiloxane containing at least two Si-bonded hydrogen atoms per molecule, and a hydrosilation catalyst. Another addition reaction-curable liquid silicone rubber composition additionally includes a specific non-functional dimethylpolysiloxane. The silicone rubber compositions are cured into products having a hardness of at least 75 as measured by a type-A durometer and an elongation at break of at least 200%. An addition reaction-curable liquid silicone rubber composition includes an organopolysiloxane containing at least one Si-bonded vinyl group only at each end of its backbone and having a viscosity of from 1 to 1,000 Pa·s at 25° C., an organopolysiloxane containing at ...more ...less
15
US20050277728A1
Publication/Patent Number: US20050277728A1
Publication date: 2005-12-15
Application number: 11/205,177
Filing date: 2005-08-17
Abstract: A composition containing a polymer compound and medium being a solvent or a binder resin, wherein the polymer compound comprises monomer units represented by the general formula (1): wherein A is a straight-chain or branched alkylene group of 1 to 15 carbon atoms, which may be substituted; m is an integer of 0 to 30, and; B is a single bond or alkylene, which may be substituted; D is an aromatic ring structure; n is an integer of 1 to 10, and R is a hydrogen atom, an alkyl group, which may be substituted, an aromatic ring structure, or a mono- or poly-valent metal cation. A composition containing a polymer compound and medium being a solvent or a binder resin, wherein the polymer compound comprises monomer units represented by the general formula (1): wherein A is a straight-chain or branched alkylene group of 1 to 15 carbon atoms, which ...more ...less
16
US20050277729A1
Publication/Patent Number: US20050277729A1
Publication date: 2005-12-15
Application number: 10/853,195
Filing date: 2004-05-26
Abstract: A pressure-sensitive adhesive composition which comprises a pressure-sensitive adhesive polymer (A), a near-infrared absorbing dye (B), an ultraviolet absorber (C) and/or a hindered amine light stabilizer (D) is provided. The pressure-sensitive adhesive composition makes it possible to lessen deterioration of the near-infrared absorbing dye used by ultraviolet rays. Also, the composition is suited for use in forming pressure-sensitive adhesive layers and the like for sticking together laminar materials forming plasma displays and the like, can combine the functions of the respective layers in the plasma display front face plate in the pressure-sensitive adhesive layer formed, is capable of absorbing near-infrared rays as well as ultraviolet rays and, further, exhibits a color tone-adjusting function. A pressure-sensitive adhesive composition which comprises a pressure-sensitive adhesive polymer (A), a near-infrared absorbing dye (B), an ultraviolet absorber (C) and/or a hindered amine light stabilizer (D) is provided. The pressure-sensitive adhesive composition makes it ...more ...less
17
US20050277732A1
Publication/Patent Number: US20050277732A1
Publication date: 2005-12-15
Application number: 10/867,146
Filing date: 2004-06-14
Abstract: A two-component coating composition that includes (A) a first component containing an acid functional aliphatic polyester polyol having an acid number of at least 20 mg KOH/g and a hydroxyl number of from 50 to 500 mg KOH/g, and (B) a second component comprising one or more polyisocyanates. The composition can be used to coat metal substrates by (i) mixing components (A) and (B) in the above-described composition to form a mixture; and (ii) applying the mixture to a surface of a metal substrate. A two-component coating composition that includes (A) a first component containing an acid functional aliphatic polyester polyol having an acid number of at least 20 mg KOH/g and a hydroxyl number of from 50 to 500 mg KOH/g, and (B) a second component comprising one or more ...more ...less
18
US20050277735A1
Publication/Patent Number: US20050277735A1
Publication date: 2005-12-15
Application number: 11/012,753
Filing date: 2004-12-15
Abstract: This invention relates to a soft thermoplastic vulcanizate composition comprising: a) from about 2-10 wt %, based upon total polymer content weight a)+b)+c), of a thermoplastic polyethylene or polypropylene homopolymer, or ethylene-propylene copolymer, or copolymer that includes ethylene or propylene together with one or more C4 to C20 α-olefins, said thermoplastic having at least 25% crystallinity by DSC; b) from about 15 to about 36 wt. %, based upon total polymer content weight a)+b)+c), of an ethylene-α-olefin random or block copolymer thermoplastic having less than 5% crystallinity by DSC; c) from about 60 to about 80 wt. %, based upon total polymer content weight a)+b)+c), of a cross-linked elastomer; and d) from about 50 to about 65 wt %, based upon total composition weight a)+b)+c)+d), of a process oil; wherein said thermoplastic vulcanizate composition has a Shore A Hardness of less than 35. The invention compositions may also comprise from about 0 to about 40 wt. %, based upon the total composition weight, of conventional additives. This invention relates to a soft thermoplastic vulcanizate composition comprising: a) from about 2-10 wt %, based upon total polymer content weight a)+b)+c), of a thermoplastic polyethylene or polypropylene homopolymer, or ethylene-propylene copolymer, or copolymer that includes ...more ...less
19
US20050277738A1
Publication/Patent Number: US20050277738A1
Publication date: 2005-12-15
Application number: 11/012,752
Filing date: 2004-12-15
Abstract: Disclosed herein are low Shore A Hardness thermoplastic vulcanizate compositions having high Rebound values. In at least one exemplary embodiment, the compositions include a dispersed at least partially vulcanized rubber component; a thermoplastic component; and process oil; wherein the weight ratio of the thermoplastic component to the rubber component ranges from 80:20 to 15:85; and the thermoplastic component comprises more than 80 wt % of a polypropylene (preferably a random propylene copolymer) having a melting point less than about 105° C. The compositions can be used in molded products, consumer goods and the like. Disclosed herein are low Shore A Hardness thermoplastic vulcanizate compositions having high Rebound values. In at least one exemplary embodiment, the compositions include a dispersed at least partially vulcanized rubber component; a thermoplastic component; and process oil; ...more ...less
20
US20050277741A1
Publication/Patent Number: US20050277741A1
Publication date: 2005-12-15
Application number: 11/154,214
Filing date: 2005-06-16
Abstract: A polymeric sorbent that can be employed in the extraction and purification of polar and nonpolar molecules from a complex media (e.g. pharmaceuticals from biological matrices) by solid phase extraction (SPE). The sorbent exhibits a strong capacity for the retention of polar molecules and can facilitate the recovery of compounds possessing a range of polarities while furnishing clean extracts showing low ion suppression. The polymer is wettable and remains wetted over long periods of time. A polymeric sorbent that can be employed in the extraction and purification of polar and nonpolar molecules from a complex media (e.g. pharmaceuticals from biological matrices) by solid phase extraction (SPE). The sorbent exhibits a strong capacity for the retention of polar ...more ...less