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1
US6905830B2
Publication/Patent Number: US6905830B2
Publication date: 2005-06-14
Application number: 10/351,067
Filing date: 2003-01-23
IPC:
Abstract: This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. The analysis can be automated or manual. The invention also relates to kits for use in the above methods. This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. The analysis ...more ...less
2
US6905835B2
Publication/Patent Number: US6905835B2
Publication date: 2005-06-14
Application number: 09/866,232
Filing date: 2001-05-25
IPC:
Abstract: A non-instrumental assay for the diagnosis of celiac disease based on the general immunochromatographic assay principles. The assay is rapid and simple and allows the reliable detection of anti transglutaminase antibodies, of both IgA and IgG isotype, in samples of human serum, plasma or blood, using as tracer the antigen transglutaminase conjugated to a colored substance, like colloidal gold or colored latex particles. The conjugated antigen is deposited onto an inert fibrous support, from where it can be released by a liquid sample. The antibodies in the sample react with the conjugated antigen developing an immunocomplex that migrates through a carrier membrane, like nitrocellulose or nylon with a pore size that allows a laminar flow of the reagents, until it reacts with the same antigen transglutaminase immobilized onto a reactive zone of the membrane. As a consequence of this reaction the immunocomplex will be trapped in the reaction site and a colored signal will be seen. Therefore a visually detectable signal in the reactive zone of the membrane indicates a positive result for the detection of anti transglutaminase antibodies in the sample. A non-instrumental assay for the diagnosis of celiac disease based on the general immunochromatographic assay principles. The assay is rapid and simple and allows the reliable detection of anti transglutaminase antibodies, of both IgA and IgG isotype, in samples of human serum ...more ...less
3
US6905839B2
Publication/Patent Number: US6905839B2
Publication date: 2005-06-14
Application number: 10/209,459
Filing date: 2002-07-31
Inventor: Furuta, Takashi  
IPC:
Abstract: In a method for evaluating in vivo human cytochrome P450 3A (CYP3A), at least a 2-hour urine collection and one blood sample are obtained. Endogenous cortisol in plasma and 6β-hydroxycortisol in urine are measured. Metabolic clearance specific for the 6β-hydroxylation of cortisol is then expressed as the amount of urinary excreted 6β-hydroxycortisol divided by the area under the concentration-time curve of cortisol, being a safe and reliable index for CYP3A phenotyping to assess in vivo CYP3A activity in humans. In a method for evaluating in vivo human cytochrome P450 3A (CYP3A), at least a 2-hour urine collection and one blood sample are obtained. Endogenous cortisol in plasma and 6β-hydroxycortisol in urine are measured. Metabolic clearance specific for the ...more ...less
4
US6905842B1
Publication/Patent Number: US6905842B1
Publication date: 2005-06-14
Application number: 08/962,560
Filing date: 1997-10-31
IPC:
Abstract: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites. The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the ...more ...less
5
US6905843B1
Publication/Patent Number: US6905843B1
Publication date: 2005-06-14
Application number: 10/019,995
Filing date: 1999-07-29
IPC:
Abstract: Disclosed are a preparation containing cell extracts for cell-free protein synthesis, prepared by excluding from a living organism a system, participating to inhibiting of self protein synthesis reaction, an apparatus for cell-free protein synthesis reaction equipped with a reaction tank for cell-free protein synthesis, and a kit for use therefor; the preparation can be stored at room temperature and prepared as a preparation in a state where biological functions of the cell extracts are maintained and further, disclosed is means for cell-free protein synthesis comprising cell extracts from which an inhibitor for self protein synthesis reaction is substantially excluded, having introduced therein treatment selected from supplement, storage, exchange or discharge with respect to an element selected from at least mRNA serving as a template for synthesis reaction, an energy reproduction system enzyme, a substrate, and an energy source. Disclosed are a preparation containing cell extracts for cell-free protein synthesis, prepared by excluding from a living organism a system, participating to inhibiting of self protein synthesis reaction, an apparatus for cell-free protein synthesis reaction equipped with a ...more ...less
6
US6905855B2
Publication/Patent Number: US6905855B2
Publication date: 2005-06-14
Application number: 10/199,334
Filing date: 2002-07-22
IPC:
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention. The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and ...more ...less
7
US6905858B2
Publication/Patent Number: US6905858B2
Publication date: 2005-06-14
Application number: 10/342,237
Filing date: 2003-01-15
IPC:
Abstract: The present invention provides thermostable enzymes, such as DNA polymerases and restriction endonucleases, that are substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising these enzymes which may be used in amplifying or sequencing nucleic acid molecules, including through use of the polymerase chain reaction (PCR). The present invention provides thermostable enzymes, such as DNA polymerases and restriction endonucleases, that are substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising these ...more ...less
8
US6905864B2
Publication/Patent Number: US6905864B2
Publication date: 2005-06-14
Application number: 10/156,562
Filing date: 2002-05-24
IPC:
Abstract: Polyaromatic hydrocarbons are found in contaminated soils and groundwater and are a large class of compounds for which treatment by bioremediation is sought. Accordingly, indigenous organisms that can degrade polyaromatic hydrocarbon are needed. Presented are strains of the Paenibacillus genus that degrade low molecule weight polyaromatic, and, in the presence of phenanthrene, high molecular weight polyaromatic hydrocarbons. These bacteria strains are unique among PAH-degrading bacterial strains because they form endospores and therefore can survive adverse environmental conditions. Among the strains presented are several from “P. naphthalenovorans”, a newly described species. Also presented are compositions for bioremediation comprising the bacterial strains of the invention, and a method for isolating the strains and a method for using the strains for bioremediation. Polyaromatic hydrocarbons are found in contaminated soils and groundwater and are a large class of compounds for which treatment by bioremediation is sought. Accordingly, indigenous organisms that can degrade polyaromatic hydrocarbon are needed. Presented are strains of the ...more ...less
9
US6905869B2
Publication/Patent Number: US6905869B2
Publication date: 2005-06-14
Application number: 09/837,239
Filing date: 2001-04-18
Assignee: Nestec S.A.
IPC:
Abstract: A method of introducing a property of a particular yeast strain, based on a recessive allele, into the genetic background of an industrial baker's yeast; as well as yeast strains obtainable according to the method. In particular, a method is disclosed to introduce an lti-property into the genetic background of industrial baker's yeast. The novel strains obtained according to the method may be used for the preparation of a dough and for the manufacture of baked products therefrom, such as on an industrial scale. A method of introducing a property of a particular yeast strain, based on a recessive allele, into the genetic background of an industrial baker's yeast; as well as yeast strains obtainable according to the method. In particular, a method is disclosed to introduce an ...more ...less
10
US6905870B2
Publication/Patent Number: US6905870B2
Publication date: 2005-06-14
Application number: 10/013,749
Filing date: 2001-11-13
IPC:
Abstract: Processes for treating compositions comprising one or more alkanes (for example crude oils) to enhance volume of the compositions are disclosed. The processes comprise introducing into the composition one or more aerobic microorganisms, thereby forming an intermediate composition, and then introducing one or more anaerobic microorganisms into the intermediate composition to form a second composition, and repeating these steps at least once. Processes for treating compositions comprising one or more alkanes (for example crude oils) to enhance volume of the compositions are disclosed. The processes comprise introducing into the composition one or more aerobic microorganisms, thereby forming an intermediate ...more ...less
11
US6908729B2
Publication/Patent Number: US6908729B2
Publication date: 2005-06-21
Application number: 10/278,978
Filing date: 2002-10-24
IPC:
Abstract: A resist film is formed from a chemically amplified resist material containing a base polymer including at least one ester out of acrylate and methacrylate and an acid generator that generates an acid when irradiated with light. The resist film is selectively irradiated for pattern exposure with extreme UV of a wavelength of a 1 nm through 30 nm band, and is developed after the pattern exposure, so as to form a resist pattern from an unexposed portion of the resist film. The resist pattern is then annealed, so as to smooth roughness having been caused on the resist pattern. A resist film is formed from a chemically amplified resist material containing a base polymer including at least one ester out of acrylate and methacrylate and an acid generator that generates an acid when irradiated with light. The resist film is selectively irradiated for ...more ...less
12
US6908730B2
Publication/Patent Number: US6908730B2
Publication date: 2005-06-21
Application number: 10/347,014
Filing date: 2003-01-17
IPC:
Abstract: This invention relates to a silver halide photographic material comprising at least one silver halide emulsion comprising silver halide grains having associated therewith: (a) a first dye (Dye 1) that is a cyanine dye capable of spectrally sensitizing a silver halide emulsion and that has at least one anionic substituent; and (b) a second dye (Dye 2) that is not a cyanine dye and that has at least one cationic substituent. Dye 2 has a log P, excluding any counterion, of less than 4.00 and greater than 1.00 or Dye 2 is represented by a dye of formula II as described herein. This invention relates to a silver halide photographic material comprising at least one silver halide emulsion comprising silver halide grains having associated therewith: (a) a first dye (Dye 1) that is a cyanine dye capable of spectrally sensitizing a ...more ...less
13
US6908731B2
Publication/Patent Number: US6908731B2
Publication date: 2005-06-21
Application number: 10/712,189
Filing date: 2003-11-13
Assignee: Agfa-Gevaert
IPC:
Abstract: A substantially light-insensitive black and white monosheet thermographic recording material comprising a support and a thermosensitive element, the thermosensitive element containing a substantially light-insensitive organic silver salt, an organic reducing agent therefor in thermal working relationship therewith, a binder and at least one stabilizer selected from the group consisting of 1-phenyl-5-mercaptotetrazole compounds in which the phenyl group is substituted with a substituent containing an optionally substituted aryl group; and A substantially light-insensitive black and white monosheet thermographic recording material comprising a support and a thermosensitive element, the thermosensitive element containing a substantially light-insensitive organic silver salt, an organic reducing agent therefor in ...more ...less
14
US6908732B2
Publication/Patent Number: US6908732B2
Publication date: 2005-06-21
Application number: 09/977,866
Filing date: 2001-10-15
Inventor: Falchuk, Kenneth H.  
IPC:
Abstract: The present invention makes available methods and reagents for inhibiting cell growth or promoting cell differentiation comprising contacting the cell with a differeguline in a sufficient amount to inhibit cell proliferation or promote cell differentiation.