Country
Full text data for US and EP
Status
Type
Filing Date
Publication Date
Inventor
Assignee
Click to expand
IPC
No.
Publication Number
Title
Publication/Patent Number Publication/Patent Number
Publication date Publication date
Application number Application number
Filing date Filing date
Inventor Inventor
Assignee Assignee
IPC IPC
1
US7803922B2
Publication/Patent Number: US7803922B2
Publication date: 2010-09-28
Application number: 12/012,156
Filing date: 2008-01-30
Assignee: Evrogen JSC
Abstract: Methods of selectively cleaving DNA containing duplex nucleic acids in a complex nucleic acid mixture, as well as nuclease containing compositions for use therein, are provided. In the subject methods, a nuclease or composition thereof is employed to provide for selective cleavage of DNA containing duplex nucleic acids in a complex nucleic acid mixture. Also provided are novel duplex-stranded specific nucleases and nucleic acids encoding the same, where the subject nucleases are enzymes that, preferentially cleave deoxyribonucleic acid molecules in perfectly matched nucleic acid duplexes as compared to non-perfectly matched nucleic acid duplexes of the same length and/or single stranded nucleic acids. The subject methods and compositions for practicing the same find use in a variety of different applications, including, but not limited to, nucleic acid analyte detection applications, gene expression profiling applications, detection of nucleic acid variants including single nucleotide polymorphisms applications, preparation of subtracted and normalized nucleic acid libraries, etc. Finally, kits for use in practicing the subject methods are provided. Methods of selectively cleaving DNA containing duplex nucleic acids in a complex nucleic acid mixture, as well as nuclease containing compositions for use therein, are provided. In the subject methods, a nuclease or composition thereof is employed to provide for selective ...more ...less
2
US7803926B2
Publication/Patent Number: US7803926B2
Publication date: 2010-09-28
Application number: 11/522,237
Filing date: 2006-09-15
Assignee: Merial SAS
Abstract: The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes. The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the ...more ...less
3
US7803931B2
Publication/Patent Number: US7803931B2
Publication date: 2010-09-28
Application number: 11/058,134
Filing date: 2005-02-14
Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
4
US7803938B2
Publication/Patent Number: US7803938B2
Publication date: 2010-09-28
Application number: 12/549,571
Filing date: 2009-08-28
Abstract: This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein. This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a ...more ...less
5
US7803949B2
Publication/Patent Number: US7803949B2
Publication date: 2010-09-28
Application number: 12/097,244
Filing date: 2006-12-20
Abstract: An object of the present invention is to provide a process, or the like, suitable for the industrialization of effective deprotection reaction without using a toxic solvent as well as to provide a process, or the like, for preparing a water-soluble azole prodrug effectively. The present invention provides a process for preparing a salt represented by Formula (I); (wherein X represents a fluorine atom bonded at position 4 or position 5 of a phenyl group) comprising the steps of: (a) carrying out a deprotection reaction of a compound represented by Formula (II); (wherein X represents a fluorine atom bonded at position 4 or position 5 of a phenyl group) in the presence of a carbocation scavenger. An object of the present invention is to provide a process, or the like, suitable for the industrialization of effective deprotection reaction without using a toxic solvent as well as to provide a process, or the like, for preparing a water-soluble azole prodrug effectively. The ...more ...less
6
US7803954B2
Publication/Patent Number: US7803954B2
Publication date: 2010-09-28
Application number: 11/520,063
Filing date: 2006-09-13
Inventor: Inghardt, Tord  
Abstract: There is provided a compound of formula (I) wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g., thrombosis) or as anticoagulants. There is provided a compound of formula (I) wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive ...more ...less
7
US7803955B2
Publication/Patent Number: US7803955B2
Publication date: 2010-09-28
Application number: 11/921,248
Filing date: 2006-06-15
Abstract: The contemplated invention relates to the field of synthesis of biologically active substances, namely to the synthesis of an acetate derivative of the main water-soluble α-tocopherol metabolite known under the name of α-CEHC, which is prepared by the acid-catalyzed reaction of condensation of trimethyl hydroquinone with linalool in boiling octane, using n-toluenesulfonic acid or (+)-camphor-10-sulfonic acid as the catalyst. The reaction is carried out for 3 hours at the trimethyl hydroquinone:linalool:catalyst mole ratio of 1:1:0.1. The forming product is acetylated with acetic anhydride in pyridine at room temperature for 0.5 hour, and then ozonized in acetone in the presence of Ba(OH)2, oxidized with Jones' reagent in acetone, and isolated on silica gel column chromatography. Said compound is an acetate derivative of the main α-tocopherol metabolite—α-CEHC, for which high efficiency has been noted in treating disorders of the central nervous system. The contemplated invention relates to the field of synthesis of biologically active substances, namely to the synthesis of an acetate derivative of the main water-soluble α-tocopherol metabolite known under the name of α-CEHC, which is prepared by the acid-catalyzed ...more ...less
8
US7803958B2
Publication/Patent Number: US7803958B2
Publication date: 2010-09-28
Application number: 11/685,264
Filing date: 2007-03-13
Abstract: A crosslinker (i.e., a curing agent) for polymerizing a film-forming material. The crosslinker is an organic compound including at least two functional groups reactive with a film-forming material and at least one pendent group comprising a —Si(OR)3 group, wherein each R is independently an alkyl group including from 1 to about 12 carbon atoms or an aryl group including substituted and unsubstituted phenyl and benzyl groups. Functional groups reactive with a film-forming materials include isocyanate, blocked isocyanate, uretdione, epoxide, hydroxyl, carboxyl, ester, ether, carbamate, aminoalkanol, aminoalkylether, amide, or amine groups. Embodiments include derivatives of the various crosslinkers as disclosed elsewhere herein, where the crosslinker has at least two functional groups reactive with a film-forming material and at least one pendent group comprising a —Si(OR)3 group. A crosslinker (i.e., a curing agent) for polymerizing a film-forming material. The crosslinker is an organic compound including at least two functional groups reactive with a film-forming material and at least one pendent group comprising a —Si(OR)3 group, wherein each R ...more ...less
9
US7803960B2
Publication/Patent Number: US7803960B2
Publication date: 2010-09-28
Application number: 11/896,607
Filing date: 2007-09-04
Abstract: The present invention relates to phenyloxyaniline derivatives, to methods of their production and to uses thereof.
10
US7803961B2
Publication/Patent Number: US7803961B2
Publication date: 2010-09-28
Application number: 12/032,385
Filing date: 2008-02-15
Abstract: A method of forming a dialkyl carbonate stream, includes obtaining a byproduct stream from a diaryl carbonate formation reaction that has alkanol, residual dialkyl carbonate, and residual aromatic compound. This byproduct stream is introduced to a distillation column to produce an alkanol tops stream and a first dialkyl carbonate bottoms stream. The alkanol tops stream is reacted with oxygen, carbon monoxide, and catalyst to form a second dialkyl carbonate stream that is introduced to the distillation column. The alkanol tops stream from the column contains alkanol, dialkyl carbonate, and less than 20 ppm aromatic compound. The first dialkyl carbonate bottoms stream from the column contains dialkyl carbonate, water, aromatic compound, and less than 2,000 ppm alkanol and is introduced to a water separation device to produce a product dialkyl carbonate stream and a water stream. A method of forming a dialkyl carbonate stream, includes obtaining a byproduct stream from a diaryl carbonate formation reaction that has alkanol, residual dialkyl carbonate, and residual aromatic compound. This byproduct stream is introduced to a distillation column to produce ...more ...less
11
US7803967B2
Publication/Patent Number: US7803967B2
Publication date: 2010-09-28
Application number: 12/388,929
Filing date: 2009-02-19
Abstract: The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV) in which R1 and R2 are as defined in the description, to intermediates and processes for their preparation and to their use as intermediates in the synthesis of insecticidal, acaricidal and herbicidal compounds or pharmaceutically active compounds. The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV) in which R1 and R2 are as defined in the description, to intermediates and processes for their preparation and to their use as intermediates in the synthesis of ...more ...less
12
US7803971B2
Publication/Patent Number: US7803971B2
Publication date: 2010-09-28
Application number: 11/575,839
Filing date: 2005-09-23
Abstract: A process for preparing cyclopentanone, at least comprising the following steps (i) to (iii): (i) providing a mixture G(i) comprising cyclopentene; (ii) providing liquid or supercritical N2O or a liquid or supercritical gas mixture G(ii) comprising at least 20% by volume of N2O, based on the total volume of the mixture G(ii); (iii) contacting the mixture G(i) with the liquid or supercritical N2O or the liquid or supercritical mixture G(ii) to obtain a mixture G(iii) comprising cyclopentanone, wherein the mixture G(i) contains at least 25% by weight and at most 95% by weight, of cyclopentene, based on the total weight of the mixture G(i). A process for preparing cyclopentanone, at least comprising the following steps (i) to (iii): (i) providing a mixture G(i) comprising cyclopentene; (ii) providing liquid or supercritical N2O or a liquid or supercritical gas mixture G(ii) comprising at least 20% by ...more ...less
13
US7803972B2
Publication/Patent Number: US7803972B2
Publication date: 2010-09-28
Application number: 12/094,288
Filing date: 2006-11-23
Abstract: The invention relates to a coated catalyst, especially for oxidation of methanol to formaldehyde, which, on an inert, preferably essentially nonporous, support body, has at least one coating which comprises, before the removal of the organic fractions of components b) and c): (a) oxides, or precursor compounds convertible to the corresponding oxides, of molybdenum and iron, where the molar ratio of Mo:Fe is between 1:1 and 5:1, and optionally further metallic components or metal oxide components or precursor compounds convertible to the corresponding oxides, (b) at least one organic binder, preferably an aqueous dispersion of copolymers, especially selected from vinyl acetate/vinyl laurate, vinyl acetate/ethylene, vinyl acetate/acrylate, vinyl acetate/maleate, styrene/acrylate or mixtures thereof, and (c) at least one further component selected from the group consisting of SiO2 sol or precursors thereof, Al2O3 sol or precursors thereof, ZrO2 sol or precursors thereof, TiO2 sol or precursors thereof, waterglass, MgO, cement, monomeric, oligomeric or polymeric silanes, alkoxysilanes, aryloxysilanes, acryloyloxysilanes, aminosilanes, siloxanes or silanols. Additionally described is a process for preparing the catalyst and its preferred use. The invention relates to a coated catalyst, especially for oxidation of methanol to formaldehyde, which, on an inert, preferably essentially nonporous, support body, has at least one coating which comprises, before the removal of the organic fractions of components b) and c): ...more ...less
14
US7803973B2
Publication/Patent Number: US7803973B2
Publication date: 2010-09-28
Application number: 12/104,176
Filing date: 2008-04-16
Abstract: Dehydrohalogenation processes for the preparation of fluoropropenes from corresponding halopropanes, in which the fluoropropenes have the formula CF3CY═CXNHP, wherein X and Y are independently hydrogen or a halogen selected from fluorine, chlorine, bromine and iodine; and N and P are independently integers equal to 0, 1 or 2, provided that (N+P)=2. Dehydrohalogenation processes for the preparation of fluoropropenes from corresponding halopropanes, in which the fluoropropenes have the formula CF3CY═CXNHP, wherein X and Y are independently hydrogen or a halogen selected from fluorine, chlorine, bromine and iodine; and ...more ...less
15
US7803980B2
Publication/Patent Number: US7803980B2
Publication date: 2010-09-28
Application number: 10/883,205
Filing date: 2004-07-01
Abstract: A multi layered wound dressing which comprises an adhesive layer, an absorbent layer overlying said adhesive layer on the surface furthest from the wound, and a moisture transmitting cover layer overlying the absorbent layer, the dressing having a total thickness of less than 1.5 mm. A multi layered wound dressing which comprises an adhesive layer, an absorbent layer overlying said adhesive layer on the surface furthest from the wound, and a moisture transmitting cover layer overlying the absorbent layer, the dressing having a total thickness of less than ...more ...less
16
US7803981B2
Publication/Patent Number: US7803981B2
Publication date: 2010-09-28
Application number: 11/820,768
Filing date: 2007-06-20
Abstract: The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies. The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by ...more ...less