Country
Full text data for US,EP,CN
Type
Legal Validity
Legal Status
Filing Date
Publication Date
Inventor
Assignee
Click to expand
IPC(Section)
IPC(Class)
IPC(Subclass)
IPC(Group)
IPC(Subgroup)
Agent
Agency
Claims Number
Figures Number
Citation Number of Times
Assignee Number
No. Publication Number Title Publication/Patent Number Publication/Patent Number Publication Date Publication Date
Application Number Application Number Filing Date Filing Date
Inventor Inventor Assignee Assignee IPC IPC
1 US2018195120A1
PREDICTING TUMOR RESPONSE TO ANTI-ERBB3 ANTIBODIES
Publication/Patent Number: US2018195120A1 Publication Date: 2018-07-12 Application Number: 15/823,227 Filing Date: 2017-11-27 Inventor: Gyuris, Jeno   Mcintosh, Donna   Nicoletti, Richard   Bottega, Steve   Tyler, Steven   Feng, Bin   Meetze, Kristan   Vincent, Sylvie   Assignee: AVEO Pharmaceuticals, Inc.   IPC: A61K39/395 Abstract: A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor. A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein ...More Less
2 US2018195121A1
METHODS AND KITS FOR TREATING CARDIOVASCULAR DISEASE
Publication/Patent Number: US2018195121A1 Publication Date: 2018-07-12 Application Number: 15/649,175 Filing Date: 2017-07-13 Inventor: Duff, Gordon W.   Docette-stamm, Lynn   Kornman, Kenneth S.   Assignee: Interleukin Genetics, Inc.   IPC: C12Q1/68 Abstract: The present invention relates, in part, to methods and kits for treating cardiovascular disease.
3 US2018195123A1
COMPOSITIONS AND METHODS FOR GENETIC ANALYSIS OF EMBRYOS
Publication/Patent Number: US2018195123A1 Publication Date: 2018-07-12 Application Number: 15/684,320 Filing Date: 2017-08-23 Inventor: Johnson, Mark T.   Assignee: Reproductive Genetics and Technology Solutions, LLC   IPC: C12Q1/6869 Abstract: This disclosure provides compositions and methods for determining a presence or absence of a genomic copy number alteration (CNA) in an embryo, wherein the method comprises analysis of RNA from an embryo or cDNA derived from this RNA. Generally, the compositions and methods provide for the acquisition of a sample containing RNA produced by an embryo, application of one or more of at least 3 different methods for detecting CNAs. One method can identify CNAs based on the identification of alterations in expression of loci or alleles affected by the CNA. Another can identify CNAs based on the identification of associated breakpoint. A third can identify CNAs based on expression profiles that are associated with CNAs. A variety of other genetic and biologic analyses can be performed on the RNA in combination with the copy number analyses. Analysis of copy number in embryos can provide information that can provide important clinical information pertaining to the health and developmental potential of an embryo that can impact the plans of the parents and clinical staff for the embryo. This disclosure provides compositions and methods for determining a presence or absence of a genomic copy number alteration (CNA) in an embryo, wherein the method comprises analysis of RNA from an embryo or cDNA derived from this RNA. Generally, the compositions and methods ...More Less
4 US2018195125A1
ASSAYS AND REAGENTS FOR DIAGNOSING TYPE 1 DIABETES
Publication/Patent Number: US2018195125A1 Publication Date: 2018-07-12 Application Number: 15/784,650 Filing Date: 2017-10-16 Inventor: Usmani-brown, Sahar   Assignee: L2 Diagnostics, LLC   IPC: C12Q1/6883 Abstract: Described herein are compositions and methods for diagnosing or monitoring type 1 diabetes.
5 US2018195128A1
Therapeutic Regimen for Hypertension
Publication/Patent Number: US2018195128A1 Publication Date: 2018-07-12 Application Number: 15/894,546 Filing Date: 2018-02-12 Inventor: Snyder, Scott C.   Sprissler, Ryan   Snyder, Eric   Assignee: Geneticure LLC   IPC: G01N33/68 Abstract: The invention relates to improved methods, devices, and kits for identifying and implementing an appropriate treatment regimen for subjects suffering from hypertension.
6 US2018195138A1
BACILLUS AMYLOLIQUEFACIENS RTI301 COMPOSITIONS AND METHODS OF USE FOR BENEFITING PLANT GROWTH AND TREATING PLANT DISEASE
Publication/Patent Number: US2018195138A1 Publication Date: 2018-07-12 Application Number: 15/864,795 Filing Date: 2018-01-08 Inventor: Lee, Jaeheon   Van, Der Lelie Daniel   Taghavi, Safiyh   Assignee: FMC Corporation   IPC: A01N51/00 Abstract: Compositions and methods include a new strain of Bacillus amyloliquefaciens having growth promoting activity and activity against plant pathogens. The compositions are useful for benefiting plant growth and/or conferring protection against a pathogenic infection when applied to plant foliage, flowers, fruits, bark, roots, seeds, callus tissue, grafts, cuttings, surrounding soil or growth medium, and soil or growth medium concomitant with sowing seed and planting callus tissue, grafts, and cuttings. The compositions containing the Bacillus amyloliquefaciens RTI301 strain can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, and fertilizers. In one example, the Bacillus amyloliquefaciens RTI301 strain can be delivered to the plant as part of an integrated pest management program, with other microbial or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, and plant growth regulators. Compositions and methods include a new strain of Bacillus amyloliquefaciens having growth promoting activity and activity against plant pathogens. The compositions are useful for benefiting plant growth and/or conferring protection against a pathogenic infection when applied to ...More Less
7 US2018195152A1
CAST MATERIAL AND METHOD OF MANUFACTURING CAST MATERIAL
Publication/Patent Number: US2018195152A1 Publication Date: 2018-07-12 Application Number: 15/741,971 Filing Date: 2016-06-30 Inventor: Tashiro, Hirofumi   Ooge, Toshikazu   Assignee: TOYO KOHAN CO., LTD.   IPC: C22C19/05 Abstract: A cast material comprising hard phase particles mainly composed of a boride and/or a carbide, and a binder phase including an alloy mainly composed of Co and/or Ni. The average particle size of the hard phase particles is 3 μm or less, the average value of the aspect ratios of the hard phase particles is 2.3 or less, the content of the hard phase particles having a major axis exceeding 5 μm is 3 particles or less per 2,450 μm2, and the contact ratio between the hard phase particles is 40% or less. A cast material comprising hard phase particles mainly composed of a boride and/or a carbide, and a binder phase including an alloy mainly composed of Co and/or Ni. The average particle size of the hard phase particles is 3 μm or less, the average value of the aspect ...More Less
8 US2018195172A1
CHEMICAL VAPOR DEPOSITION APPARATUS AND CHEMICAL VAPOR DEPOSITION METHOD
Publication/Patent Number: US2018195172A1 Publication Date: 2018-07-12 Application Number: 15/740,951 Filing Date: 2016-07-08 Inventor: Yamaguchi, Kenji   Tatsuoka, Sho   Assignee: MITSUBISHI MATERIALS CORPORATION   IPC: C23C16/34 Abstract: A chemical vapor deposition apparatus includes a reaction chamber in which a deposition material is accommodated, a gas supply tube provided in the reaction chamber, and a rotary drive device that rotates the gas supply tube around a rotation axis in the reaction chamber, in which an inside of the gas supply tube is partitioned into the first and second gas flowing sections extending along the rotation axis, a set of gas ejection ports including at least three or more the gas ejection ports disposed, lying next to each other in the circumferential direction is installed on the tube wall, and the set of gas ejection ports includes at least one of a first gas ejection port ejecting the first gas flowing through the first gas flowing section, and at least one of the second gas ejection port ejecting a second gas flowing through the second gas flowing section. A chemical vapor deposition apparatus includes a reaction chamber in which a deposition material is accommodated, a gas supply tube provided in the reaction chamber, and a rotary drive device that rotates the gas supply tube around a rotation axis in the reaction chamber, in ...More Less
9 US2018195206A1
OXYGEN-DOPED GROUP III METAL NITRIDE AND METHOD OF MANUFACTURE
Publication/Patent Number: US2018195206A1 Publication Date: 2018-07-12 Application Number: 15/865,391 Filing Date: 2018-01-09 Inventor: D'evelyn, Mark P.   Ehrentraut, Dirk   Jiang, Wenkan   Assignee: SORAA, INC.   IPC: C01B21/06 Abstract: A gallium-containing nitride crystals are disclosed, comprising: a top surface having a crystallographic orientation within about 5 degrees of a plane selected from a (0001) +c-plane and a (000-1) −c-plane; a substantially wurtzite structure; n-type electronic properties; an impurity concentration of hydrogen greater than about 5×1017 cm−3; an impurity concentration of oxygen between about 2×1017 cm−3 and about 1×1020 cm−3; an [H]/[O] ratio of at least 0.3; an impurity concentration of at least one of Li, Na, K, Rb, Cs, Ca, F, and Cl greater than about 1×1016 cm−3; a compensation ratio between about 1.0 and about 4.0; an absorbance per unit thickness of at least 0.01 cm−1 at wavenumbers of approximately 3175 cm−1, 3164 cm−1, and 3150 cm−1; and wherein, at wavenumbers between about 3200 cm−1 and about 3400 cm−1 and between about 3075 cm−1 and about 3125 cm−1, said gallium-containing nitride crystal is essentially free of infrared absorption peaks having an absorbance per unit thickness greater than 10% of the absorbance per unit thickness at 3175 cm A gallium-containing nitride crystals are disclosed, comprising: a top surface having a crystallographic orientation within about 5 degrees of a plane selected from a (0001) +c-plane and a (000-1) −c-plane; a substantially wurtzite structure; n-type electronic properties; ...More Less
10 US2018195210A1
Insulated Conductive Strands With Polymer Cores
Publication/Patent Number: US2018195210A1 Publication Date: 2018-07-12 Application Number: 15/912,291 Filing Date: 2018-03-05 Inventor: Hamada, Yohji   Mayer, Kirk M.   Crews, Kathryn P.   Maasberg, John Arthur   Podhajny, Daniel A.   Sunshine, Daniel D.   Assignee: Apple Inc.   IPC: D03D1/00 Abstract: An item may include fabric or other materials formed from intertwined strands of material. The item may include circuitry that produces signals. The strands of material may include non-conductive strands and conductive strands. The non-conductive strands and conductive strands may be close in size. The conductive strands may carry the signals produced by the circuitry. Each conductive strand may have a strand core, a conductive coating on the strand core, and an insulating coating on the conductive coating. The strand cores may be strands formed from polymer. The conductive coating may be formed from metal. The insulating coating may have a relatively thin thickness and may be formed from a polymer. An item may include fabric or other materials formed from intertwined strands of material. The item may include circuitry that produces signals. The strands of material may include non-conductive strands and conductive strands. The non-conductive strands and conductive strands ...More Less
11 US2018195211A1
CONNECTING MEMBER FOR CONNECTING ELEMENTS OF A SHED FORMING MECHANISM FOR A WEAVING MACHINE WITH EACH OTHER
Publication/Patent Number: US2018195211A1 Publication Date: 2018-07-12 Application Number: 15/741,104 Filing Date: 2016-06-27 Inventor: De, Medts Frederik   Assignee: NV Michel Van De Wiele   IPC: D03C3/40 Abstract: A connecting member (10) for connecting elements of a shed forming mechanism for a weaving machine with each other comprises at least two components (14, 16, 18) made of materials having different densities.
12 US2018194716A1
THERAPEUTIC COMPOUNDS AND METHODS OF USE
Publication/Patent Number: US2018194716A1 Publication Date: 2018-07-12 Application Number: 15/864,562 Filing Date: 2018-01-08 Inventor: Booth, Raymond G.   Assignee: University of Florida Research Foundation, Incorporated   IPC: C07C211/42 Abstract: The invention relates to protein biding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C disorders, including diseases and disorders mediated by GPCRs.
13 US2018194725A1
PYRROLOMYCINS AND METHODS OF USING THE SAME
Publication/Patent Number: US2018194725A1 Publication Date: 2018-07-12 Application Number: 15/743,427 Filing Date: 2016-07-15 Inventor: Liu, Yan   Li, Rongshi   Bayles, Kenneth   Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA   IPC: A61P35/00 Abstract: Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.
14 US2018194739A1
METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA
Publication/Patent Number: US2018194739A1 Publication Date: 2018-07-12 Application Number: 15/847,430 Filing Date: 2017-12-19 Inventor: Yang, Guang   Tan, Li   Gray, Nathanael S.   Buhrlage, Sara Jean   Treon, Steven P.   Assignee: Dana-Farber Cancer Institute, Inc.   IPC: C07D405/12 Abstract: The present invention provides compounds of any one of Formulae (A), (I-11), (II), and (V) (e.g., compounds of Formula (A-1)-(A-18)), and methods for treating Waldenström's macroglobulinemia (WM) and other B cell neoplams in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also provided are methods to treat B cell neoplasms using the compounds in combination with inhibitors of Bruton's tyrosine kinase (BTK), interleukin-1 receptor-associated kinase 1 (IRAK1), interleukin-1 receptor-associated kinase 4 (IRAK4), bone marrow on X chromosome kinase (BMX), phosphoinositide 3-kinase (PI3K), transforming growth factor b-activated kinase-1 (TAK1), and/or a Src family kinase. The present invention provides compounds of any one of Formulae (A), (I-11), (II), and (V) (e.g., compounds of Formula (A-1)-(A-18)), and methods for treating Waldenström's macroglobulinemia (WM) and other B cell neoplams in a subject using the compounds. The methods ...More Less
15 US2018194740A1
DEOXYURIDINE TRIPHOSPHATASE INHIBITORS CONTAINING AMINO SULFONYL LINKAGE
Publication/Patent Number: US2018194740A1 Publication Date: 2018-07-12 Application Number: 15/740,787 Filing Date: 2016-07-07 Inventor: Shirude, Pravin S.   Spyvee, Mark   Ladner, Robert D.   Assignee: CV6 Therapeutics (NI) Limited   University of Southern California   IPC: A61P35/02 Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
16 US2018194757A1
NEPRILYSIN INHIBITORS
Publication/Patent Number: US2018194757A1 Publication Date: 2018-07-12 Application Number: 15/791,713 Filing Date: 2017-10-24 Inventor: Hughes, Adam D.   Gendron, Roland   Assignee: THERAVANCE BIOPHARMA R&D IP, LLC   IPC: C07D405/12 Abstract: In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, R4, and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds. In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, R4, and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention ...More Less
17 US2018194770A1
PDE9 INHIBITORS WITH IMIDAZO TRIAZINONE BACKBONE AND IMIDAZO PYRAZINONE BACKBONE FOR TREATMENT OF PERIPHERAL DISEASES
Publication/Patent Number: US2018194770A1 Publication Date: 2018-07-12 Application Number: 15/742,086 Filing Date: 2016-07-06 Inventor: Wang, Yazhou   Wen, Kate   Svenstrup, Niels   Assignee: H. LUNDBECK A/S   IPC: A61P7/00 Abstract: The present invention relates to PDE9 inhibitors and their use for treatment of benign prostate hyperplasia and sickle cell disease.
18 US2018194780A1
BRIDGED BICYCLIC KALLIKREIN INHIBITORS
Publication/Patent Number: US2018194780A1 Publication Date: 2018-07-12 Application Number: 15/807,331 Filing Date: 2017-11-08 Inventor: Yu, Ming   Yee, Calvin W.   Xu, Qing   Sham, Hing   Setti, Lina Q.   Yu, Chul   Zancanella, Manuel   Li, Zhe   Assignee: GLOBAL BLOOD THERAPEUTICS, INC.   IPC: C07D405/12 Abstract: Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
19 US2018194790A1
Metal Complexes, Methods, and Uses Thereof
Publication/Patent Number: US2018194790A1 Publication Date: 2018-07-12 Application Number: 15/905,385 Filing Date: 2018-02-26 Inventor: Turner, Eric   Li, Jian   Assignee: Turner, Eric   Li, Jian   IPC: C07F1/12 Abstract: Metal complexes that exhibit multiple radiative decay mechanisms, together with methods for the preparation and use thereof.
20 US2018194794A1
Activated N-Acetylated Sugars and Oligosaccharides
Publication/Patent Number: US2018194794A1 Publication Date: 2018-07-12 Application Number: 15/736,126 Filing Date: 2016-06-15 Inventor: Aminova, Leila   Assignee: zuChem, Inc.   IPC: C12N9/90 Abstract: The invention relates to production of uridine-5′diphospho-N-acetylglucosamine and uridine-5′diphospho-N-acetylgalactosamine. The invention further relates to the production of lacto-/V-triose II and globotetraose.